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박무석 ( Moo Suk Park ),신동환 ( Dong Hwan Shin ),정경영 ( Kyung Young Chung ),정재희 ( Jae Hee Cheong ),정재호 ( Jae Ho Chung ),김도훈 ( Do Hoon Kim ),김세규 ( Se Kyu Kim ),장준 ( Joon Chang ),김주항 ( Joo Hang Kim ),김성규 ( Su 대한내과학회 2002 대한내과학회지 Vol.63 No.5
N/A Background : To define the final outcome of large cell carcinoma (LCC) after surgical treatment, we reviewed the histopathology, clinical features and follow-up results of 28 cases. Methods : We retrospectively reviewed 28 patients with LCC who underwent surgical resection during the last 15 years from 1986 to 2001 in Severance Hospital. We evaluated clinical data, radiologic findings, pathologic findings, treatment modalities, and survival. Results : The prevalence of LCC was 2.9% (29 cases) among the surgically resected cases in primary lung cancer (1003 cases) during 15 years. The mean age was 59 years old and twenty five cases were male. There were 23 smokers and the average pack year was 33. The cough was the most frequent symptom. Fifteen cases were located in the peripheral part of the lung. Twenty cases consisted of lobulated mass. In chest CT scan, twenty six cases had necrotic portions which appeared to be lower density. Postoperative stage was IA in 1 case (3.6%), IB in 11 cases (39.3%), IIB in 8 cases (28.5%), IIIA in 7 cases (25%), and IV in 1 case (3.6%). Preoperative and postoperative stage concordance rate was 43%. Median survival time was 54.5 months and 5 year-survival rate was 45%. Conclusion : Our results suggest that LCC in the lung is predominant in male and is equally located in the central and peripheral parts of the surgically resected cases. To define the treatment outcome and risk factors of LCC of the lung, further multicenter studies are needed. (Korean J Med 63:496-506, 2002) Key Words : Carcinoma, Large cell, Diagnosis, Treatment outcome
이현철(Hyun Chul Lee),김경래(Kyung Rae Kim),허갑범(Kap Bum Huh),박찬일(Chan Il Park),정재희(Jae Hee Chung),박정수(Cheong Soo Park),이광재(Kwang Jae Lee),정현채(Hyun Chae Jung) 대한내과학회 1991 대한내과학회지 Vol.41 No.6
N/A differences along geographical lines. This study was a review and analysis of 38 cases of occult papillary thyroid carcinoma detected incidentally and by means of nodaly metastasis at thyroid operations at Severance Hospital and Yongdong Severance Hospital. The results were as follows: 1) Six cases (15.8%) were male and 32 (84.2%) female. The femals outnumbered the males bya ratio of 5. 3tol. 2) The mean age of the patients was 42.9 years with a range of 21 to 67 years. The frequency of occult papillary carcinoma did not increase with age when the different age classes of the patients were compared, but there was a slight rise in middle age. 3) The mean size of 38 cases was 6.84 mm, with a range of less than 2 mm to 15 mm, which did not correlate with age or sex. It was larger in the invasive type (7.3mm) than in the circumscribed type (5.9mm). 4) Single lesion was present in 24 cases 963.2%0 and multiple in 14 cases (36.8%). 5) Twenty-two out of 38 cases (65.8%) were of the invasive thpe, and the other 13 cases (34.2%) were of the circumscribed type. Of the 25 cases with invasive type, 15 cases (60.0%) were unifocal and l0 cases (40.0%) multifocal. 6) The rate of nodal metastasis was 60.5%. It was higher in the invasive type (72.0%) than in the circumscribed type (38.59%). The mean size of the lesion with nodal metastsis was 7.48 mm with a range of less than 2mm to 15mm,