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      • KCI등재

        Correlation Analysis and Prognostic Impact of 18F-FDG PET and Excision Repair Cross-Complementation Group 1 (ERCC-1) Expression in Non-Small Cell Lung Cancer

        정용효,이충근,조관형,황상현,차종태,이정원,윤미진,조아서 대한핵의학회 2015 핵의학 분자영상 Vol.49 No.2

        Purpose The aim of this study was to determine the relationship between [18]-2-fluoro-2-deoxy-D-glucose (FDG) uptake and excision repair cross-complementation group 1 (ERCC-1) expression and to evaluate the prognostic effect of these two factors in resectable non-small cell lung cancer (NSCLC) patients. Methods We retrospectively reviewed 212 patients with resectable NSCLC who underwent FDG positron emission tomography/computed tomography (PET/CT) scan for cancer staging and ERCC-1 expression analysis between January 2008 to December 2011. All patients were then followed-up for survival analysis. Semiquantitative evaluation of ERCC-1 was performed with the H-scoring system and was correlated with maximum standardized uptake value (SUVmax) of NSCLC. Univariate andmultivariate analyseswere performed to evaluate for FDG uptake and ERCC-1 expression predicting overall survival. Results In 212 patients (139 male, median age 68±9.11), 112 patients had ERCC-positive tumors and 100 patients had ERCC-negative tumors. There was no significant difference in SUVmax between ERCC-1-positive tumors (8.02±5.40) and ERCC-1-negative tumors (7.57±6.56, p=0.584). All patients were followed-up for a median of 40.5 months (95 % confidence interval [CI], 38.5–42.2 months). Univariate analysis and multivariate analysis for all patients showed that both ERCC-1 expression (hazard ratio [HR], 2.78; 95 % CI, 1.20–6.47) and FDG uptake (HR, 4.50; 95 % CI, 2.07–9.77) independently predicted overall survival. Conclusions We have found no statistical correlation between FDG uptake and ERCC-1 expression in NSCLC. However, both higher FDG uptake and positive ERCC-1 expression are independent predictive markers of prognosis, suggesting that both should be obtained during patient workup.

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        건물 설비시스템의 측정 및 조사에 의한 적정용량 산정방안

        정용효(Yong-Ho Jung) 한국생활환경학회 2001 한국생활환경학회지 Vol.8 No.3

        The mechanical designers has been utilized the Japanese design data for the building mechanical system design or data applied previously by the senior engineer without any consideration of Korean situation owing to the shortage of the proper data available in Korea. Most of buildings have the excessive equipment capacity, because they have no conviction of design data. And mechanical system designers do not reflect the design results to the next design after the end of mechanical design. So excessive safety factor is applied at the schematic design phase of the buildings. Excessive safety factor is the major reason to increase the initial cost of the building construction. In this study, building facility and management survey was carried out and effective method for the optimal design was studied. The survey items were cooling energy use, interview with building operator.

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