전신홍반루푸스 치료 중 발생한 루푸스 장염

정병수 ( Byoung Soo Chung ),김민성 ( Min Sung Kim ),나찬호 ( Chan Ho Na ),신봉석 ( Bong Seok Shin ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.8

Systemic lupus erythematosus is a multisystemic autoimmune inflammatory disease with a variety of presenting features and manifestations. Gastrointestinal complications are common in patients with systemic lupus erythematosus, and lupus enteritis is a major cause of acute abdominal pain in the patients suffering with systemic lupus erythematosus. We report here on a 41-year-old-woman with systemic lupus erythematosus and who had developed an acute abdomen during treatment with systemic glucocorticoid and antimalarial drugs. Lupus enteritis was strongly suspected according to the clinical manifestations and the findings of the abdominal computerized tomography scan. She recovered after being treated with intravenous high dose glucocorticoid and conservative therapy. (Korean J Dermatol 2009;47(8):956~959)

학령기 아동의 모원주 ( Hair Cast ) 에 관한 고찰

정병수(Byoung Soo Chung),오창남(Chang Nam Oh) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.5

산업민주주의의 이념과 목표

정병수 ( Byoung Soo Chung ) 한국경제학회 1988 經濟學硏究 Vol.36 No.1

사람 태아 모낭과 표피에서 Prekeratin 및 Keratin의 분포에 관한 면역조직화학적 연구

정병수(Byoung Soo Chung),신동식(Dong Sik Shin) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.1

Authors attempted to examine the development of keratinocyte in the human fetal epiderrnis in term of the appearance of principal product of differentiation, the keratins. Immunohistochemical study (ABC method) using anti-prekeratin antibodies and anti-keratin antibodies was carried out on sampled skin from 9 human fetuses ranging in estirnated gestational age from 12 weeks to 27 weeks. As early as 12 weeks of embryonic life, the epidermis contained cytokeratin. At this stage of development, the embryonic epidermis consists of three-cell layer .' basal layer, intermediate layer, and periderm, all of them staining for prekeratin and keratin. A thick cornified layer developed at 24 weeks but was not stained for prekeratin and keratin. Hair germ of 12 week-fetus was recognized as bulges of basal cells that were stained for prekeratin and keratin. At 18 weeks of estimated gestational age, development has advanced to the bulbous hair peg stage at which point the primordia of nearly all the final structural components of follicles were established. In the final structureal cornponents of the follicles, outer root sheath and sebaceous gland were stained for prekeratin and keratin, whereas cortical and cuticular elements and inner root sheath were negative. There was no difference between immunostaining results for prekeratin and keratin except for the staining intensity. The appearance of these proteins early in development suggests their potential value in utero in the recognition of keratinization disorders. (Kor J Dermatol 28(l): 1 10, 1990)

우췌양(우贅樣) 모반(母斑)에서 발생(發生)한 유두장(乳頭狀) 한낭선종(汗囊腺腫) 1예(例)

정병수 ( Byoung Soo Chung ),민병근 ( Byoung Geun Min ),최규철 ( Kyu Cherl Choi ),김형균 ( Hyoung Kyun Kim ) 대한피부과학회 1983 大韓皮膚科學會誌 Vol.21 No.6

Trichonodosis

정병수,홍문희,김영균 ( Byoung Soo Chung,Moon Hee Hong,Young Kyun Kim ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.6

Trichonodosis(knotted hair) is a disorder of the hair shaft that can comprise a single or double knot. Reports of trichonodosis are not cornmon in dermatological literature, but it is generally considered not to be rare. Two varieties of trichonodosis have been described. A rare type occurs in association with abnormally growing scalp and body hair that tends to splinter and fracture. A more comrnon form occurs when normal hair is subjected to rnechanical forces, such as combing and brushing. Trichonodosis occurs exclusively in persons with curly or kinky hair. We report a patient with short, straight hair and trichonodosis. The most likely cause in our patient is trauma as a result of continual rubbing of hairs. (Korean J Dermatol 1997;35(6): 1241-1243)

조갑 진균증의 원인균 및 배양법에 관한 고찰

김승용,정병수,최규철 ( Seung Yong Kim,Byoung Soo Chung,Kyu Cherl Choi ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.1

This mycological and cultural investigation was made in 86 cases of onychomycosis diagnosed on positive KOH wet mount at Chosun University Hospital from October, 1989 to February, 1990. The results were as follows : l. The ratio of male to female was 1.2:1. According to Zaiass classificat.ion, distal subungual onychomycosis (DSO) was the most predominant type(79 cases) and others, in decreasing frequency, were superficial white onychomycosis (SWO) (Fcases), total dyst,rophic onychomycosis (TDO) (1 cases, and proximal subungual onychomycosis (PSO) was not. found. 2. In DSO, isolat,ed fungi were T. mentagrophyte(31 cases), i'. rubrum(23 c<ses), saprophyt.es(7 cases) and C albicans (5 cases). In SWO, 2 species were isolated, which were T. mentagraphytes (5 cases) and saprophyte (1 case). C. albicans was cultured in one case of TDO. 3. Eight cases of iisolat,ed sapr ophytes were Aspergillus ( 5 cases), Scopulariopsis (1 case), Hormodendrum(1 case), and Cepalosporium(1 case). Saprophytes were tound only in toe nails. 4. Uo saprophytes were isolated from coexisting skin lesi.ons. Among 10 cases of coexisting tinea manus and/or tinea corporis, T. rubrum were cultured in 8 cases. 5. The positive rate of culture by two different sampling methods and media was as follows : On Sabouraud glucose agar media, it was 47.7% (41 cases) by clipping methodand 40.7% (35 Cases) by file-method. On dermatophyte test medium, it was 43.0 (3'7 eases) by cliipping method and 45.3% (39 cases) by file-method. It seem that the selection of sampling site is important in increasing the positive rate in culture of onychomyc.osis. (Kor J Dermatol 29(1): 50 55, 1991)

피부사상균증의 임상적 및 균학적 관찰

민병근(Byoung Keun Min),정병수(Byoung Soo Chung),최규철(Kyu Cherl Choi),김형균(Hyoung Kyun Kim) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.6

N/A The influence of serum IgE level on T cell function and number in atopic dermatitis was performed. For the study we selected 2 groups of atopic derrnatitis patients which were 10 cases of atopic dermatitis patients with more than 400 IU/ml of serum 1gE level and 1(l cases with less than 400 IU/ml, The lymphocyte transformation test with phytohernagglutinin and E-rosette test with AET treated sheep cell were perforrned in each group and compare the result of each group with each other and al`o with those of control group. The reults are as follows; l. The mean serum level of IgE in AD(538. 8 407.42 IU/ml) was higher than in normal control(126. 5 133, R8 IU/ml) (p$lt;0.01). 2 The mean LTT S.I. in AD(8.83 -3.85) was lower than in nomnal control (13.99 5.55) (p$lt;0.01). 3. The mean percentage of E-rosette in AD(68,65+6.6g) was lower than 4pp IU/ml(mean+2x SD of serum IgE of control groups), 1) The LTT S, I. was decreased in both groups according to increment of serum IgE, The higher IgE group(8.64+3,9p) had statistical significance compared to normal control(13.gg+5.55) (p$lt;0.01) but not in low IgE group(9.08:4.11).2) The percentage of E-rosette was decreased in both groups according to increment of serum IgE. The both groups of low IgE(71.08.-6,24) and high IgE(66. 22 6. R7) had statistical significance compared to normal control(77.65+4.39 % ) (p 0.01).

모반세포성 모반과 악성 흑색종의 integrin 과 bcl - 2 발현에 관한 면역조직화학적 연구

박종준,정병수 ( Jong Jun Park,Byoung Soo Chung ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.2

Background: The integrins comprise a family of transmembrane glycoproteins which mediate cell-cell and cell-matr ix intera ctions, and the bcl-2 oncogene is involved in tumorigenesis by blocking apoptosis. Typical acquired melanocytic nevi appear to follow a life cycle characterized by active growth, maturation, and progressive involution. In contrast, congenital rnelanocytic nevi have a different course and prcgnosis with potential for development of melanoma, and metastatic spread is very common in malignant melanoma. Objective . We investigated the expression of integrins(a2,a3,a) and bcl-2 in congenital and acquired rnelanocytic nevi, and malignant, melanomas by immunohistochemical technique. Methods . Formalin-fixed and paraffin-embedded tissues from 7 compound nevi, 7 intradermal nevi, 5 congenital melanocytic nevi, and 5 malignant melanomas were immunolabeled with monoclonal antibodies directed against a2, a3,and a integrin, and bcl-2 protein. Results : All acquired and congenital melanocytic nevi showed a uniform staining for a2, a3, a and bcl-2. In 3 compound nevi which the nevus cells lie mainly within the upper dermis, the nevus cells in the papillary dermis showed weak to negative a expression. Within neurotized are as of intradermal nevus, bcl-2 and a expression became weaker and totally absent. All 5 malig- nant melanomas exhibited strong a2, a3, a, and bcl-2 expression. However, the tumor cells in the lower advancing border failed to express a integrin in 3 of 5 malignant, melanomas. In most malignant melanomas, there was variable intensity of staining for bcl-2 in different areas of the tumor. Conclusion . These findings suggest that the integrins and bcl-2 may be involved in active growth, maturation, and progressive involution of the melanocytic nevi, and seem to be related to metastasis and tumorigenesis of the malignant melanoma. (Kor J Dermatol 1997;35(2): 234-241)

혈관지방종 4예

민병근(Byoung Geun Min),정병수(Byoung Soo Chung),김영창(Young Chang Kim),최규철(Kyu Cherl Choi) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.1

The angiolipoma is well circumscribed, benign neoplasm, composed of mature fat cells and well developed arterioles, venules and capillaries, in which fibrin thrombi often form. We experienced 4 adult male patients who had free movable, subcutaneous nodular masses on the upper extremities, the abdomen, the back and the buttock. All of them were confirmed as angiolipoma by the clinical and histopathological findings.