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        • 자가 슬괵건을 이용한 전방 십자인대 재건술시 경골측 골 터널내 고정의 의의 (이차관절경 검사의 평가)

          김영창,서승석,정경칠,곽희철,김윤준,김진석,Kim, Young-Chang,Seo, Seung-Suk,Jung, Kyung-Chil,Gwak, Hey-Chul,Kim, Yoon-Jun,Kim, Jin-Seok 대한관절경학회 2006 대한관절경학회지 Vol.10 No.2

          목적: 자가 슬괵건을 이용한 관절경하 전방십자인대 재건술시 이식건의 경골측 골 터널내 고정의 유용성을 이차 관절경 검사의 추시 관찰을 통하여 평가 하고자 하였다. 대상 및 방법: 1999년 12월부터 2005년 5월까지 자가 슬괵건을 이용한 전방 십자인대 재건술을 시행한 환자 중 이차 관절경 검사를 시행한 32례를 대상으로 하였다. 경골측의 고정방법에 따라 나사못 실고정만을 시행한 군(제 1군)과 나사못 실고정과 간섭나사를 이용한 경골측 골 터널내 고정을 함께 시행한 군(제 2군)으로 구분하였다. 이차 내시경 추시 관찰시의 평균 나이는 30세였으며 남자가 30례, 여자가 2례였고 전방십자인대 재건술 후 이차 관절경 검사를 시행한 기간은 평균 21.3개월이었다. 결과는 마취하의 KT-1000 관절계와 IKDC 분석 및 경골측 골 터널의 크기와 Telos 스트레스 부하 검사를 방사선학적으로 평가하였으며, 이차 관절경 소견의 평가 또한 시행하였다. 결과: 평가한 IKDC분석 및 Telos스트레스 부하 방사선 검사상의 전이 정도와 KT-1000 관절계상의 전이정도는 제2군에서 우수한 소견을 보였으나, 통계적으로 의미 있는 차이를 보이진 않았다. 관절 내시경상의 이식건의 긴장도, 이식건의 육안 소견, 이식건의 활액막 증식 정도도 제2군에서 우수한 소견을 보였으나, 통계적으로 의미 있는 차이를 보이진 않았다. 전후면 방사선 사진상 경골측의 골터널의 확장은 제1군에서 2.3 mm 및 제2군에서 1.7 mm로 측정되어 통계적으로 의미 있는 차이를 보였다(P=0.042). 결론: 자가 슬괵건을 이용한 십자 인대 재건술에서 경골측 골 터널내 고정의 부가하는 시술은 경골측 골터널의 확대를 의미 있게 감소 시켰으나 수술 후의 임상적 결과, 관절의 동요 정도, 관절경적 소견에 있어 유의한 차이는 보이지 않았다. 본 연구에서 경골측 고정을 위해 나사못 실고정 단독으로 사용하여도 만족스러운 임상적 결과, 관절의 안정도, 이식건의 성숙을 얻을 수 있었고 경골측 골터널의 확대는 결과에 영향을 미치지 않는다는 것을 알 수 있었다. Purpose: The purpose of this study is to evaluate the effects of intratunnel fixation in the tibial side on the arthroscopic ACL reconstruction with quadruple hamstring tendon at the second look arthroscopy. Materials and Method: From Dec 1999 to May 2005, we arthroscopically reexamined 32 cases who had been done arthroscopic ACL reconstruction with quadruple hamstring tendons. Hamstring tendons of all cases were fixed at femoral side with RigidfixTM. At the tibial side hamstring tendons were fixed only Post-tie (Group I) or Post-tie combined with IntrafixTM (Group II). At the time of second look arthroscopy mean age of cases was 30 years and mean duration for second look arthroscopy was 21.3 months. We analyzed the results with IKDC score, KT-1000 arthrometer under anesthesia, Telos stress radiography, tibial tunnel widening on the radiography and second look arthroscopic findings. Results: Group II had more superior than group I at side to side differences with KT-1000 and Telos stress radiograph, IKDC score, but the differences were insignificant. At arthroscopic evaluation, Group ll also had more superior than group I at graft tension and graft appearance, graft synovialization, but the differences were insignificant. Tibial tunnel widening in the knee AP radiograph was 2.3 mm in Group I and 1.7 mm in Group II and the difference was significant. (P=0.042) Conclusions: Additional procedure of tibial intratunnel fixation in arthroscopic ACL reconstruction with autogenous hamstring tendon significantly prohibited from tibial tunnel widening but clinical results, radiologic joint stability, findings in second look arthroscopy were insignificantly different. We concluded that Post-tie itself induced satisfactory clinical results, joint stability and graft maturation and that tibial tunnel widening did not affect the results.

        • KCI우수등재

          인삼 종자의 개갑률 향상을 위한 적정 수확시기 및 GA<sub>3</sub> 처리 효과

          김영창,김영배,박홍우,방경환,김장욱,조익현,김기홍,송범헌,김동휘,Kim, Young Chang,Kim, Young Bae,Park, Hong Woo,Bang, Kyong Hwan,Kim, Jang Uk,Jo, Ick Hyun,Kim, Kee Hong,Song, Beom Heon,Kim, Dong Hwi 한국약용작물학회 2014 韓國藥用作物學會誌 Vol.22 No.6

          This study was performed to identify optimal harvesting time of ginseng seeds and to examine the effect of $GA_3$ treatment for improvement of seed stratification rate. Ginseng seeds harvested from Land race, Chunpoong and Yunpoong cultivar in July 20 were tested for stratification rate. It was shown that stratification rates of land race, Yunpoong and Chunpoong cultivar were 94.1%, 93.1%, and 82.6%, respectively. Seeds of Chunpoong cultivar harvested 10-15 days later showed a comparable stratification rate to that of Land race, indicating that late harvest of Chunpoong seeds is beneficial for the increase of stratification rate. The higher stratification rate was found in mature seeds (92.3%) than immature seeds (37.8%), both of which were harvested in July 20. Stratification rate of mature seeds harvested in July 15 was 87.5%, demonstrating optimal harvesting time of ginseng seeds with higher stratification rate is after mid-July. An exponential growth of endosperms of ginseng seeds was observed from early June to mid-June and then slow growth was observed. There was no obvious growth of embryos from fertilization to mid-August. After the this time, embryos quickly grew until late October. Thus, appropriate stratification control is essential during the period (from early September to late October) in order to optimize embryo growth and development. While no increase of stratification rate was observed in seeds treated with 50 ppm of $GA_3$, significant increases were observed in seeds treated with 100 ppm of $GA_3$. At this concentration of $GA_3$, the stratification rate of Land race, Chunpoong and Yunpoong cultivar was 95.0%, 95.3%, and 96.5%, respectively.

        • KCI등재후보

          족무지 종자골에 발생한 무혈성 골괴사증(3예 보고)

          김영창,곽희철,김정한,문상원,Kim, Young-Chang,Gwak, Heui-Chul,Kim, Jung-Han,Moon, Sang-Won 대한족부족관절학회 2009 대한족부족관절학회지 Vol.13 No.2

          Although avascular necrosis of the hallucal sesamoid has not been frequently addressed in the literature, it should be considered in the differential diagnosis of persistent forefoot pain. We experienced 3 cases of avascular necrosis of the hallucal sesamoid with sclerosis of the sesamoid bone on radiograghs and computed tomograghy images. T1 and T2-weighted MRI images in 2 patients showed low signal intensity in the sesamoid bone, which suggested osteonecrosis and confirmed by histology. We report 3 cases of avascular necrosis of sesamoid with a review of the literature.

        • KCI등재

          의과대학 학생 임상실습을 위한 교육병원의 역할 제고 방안

          김영창,Kim, Young Chang 연세대학교 의과대학 2015 의학교육논단 Vol.17 No.1

          The mission of the modern medical school includes education, research, and patient care. The clinical clerkship is an important part of the core curriculum, and hospital facilities are needed for the clinical clerkship. However, unfortunately, education has moved to the periphery during the past several decades because of the dominance of research and patient care. This may lead to obstacles in the education of future physicians in the long term. To promote their education mission, teaching hospitals need to recognize and share the importance of this mission. In addition to the certification of teaching hospitals, a new paradigm for teaching hospitals should be introduced to produce a high quality clinical clerkship and postgraduate medical education. The relevant government departments need to allocate and expand financial support to medical schools and teaching hospitals, and to unify supervision of basic and postgraduate medical education.

        • KCI등재

          만성 족관절 불안정성에서 하신전 지지대 및 원위 비골 골막을 이용한 해부학적 재건술

          김영창,곽희철,정경칠,최장석,서진혁,Kim, Young-Chang,Gwak, Heui-Chul,Jung, Kyung-Chil,Choi, Jang-Seok,Seo, Jin-Hyuk 대한족부족관절학회 2007 대한족부족관절학회지 Vol.11 No.2

          Purpose: To evaluate the results of surgical reconstruction of lateral capsule-ligament complex with reinforcement by periosteal flap of distal fibula and inferior extensor retinaculum for chronic lateral ankle instability. Materials and Methods: From April 2003 to August 2006, 62 patients with chronic lateral ankle instability were operated. There were 38 males and 24 females with a mean age of 39.6 years (range, $18{\sim}61$ years). Mean follow-up period was 32 months (range, $10{\sim}48$ months). All patients were checked with preoperative ankle anteroposterior and lateral view, stress anterior drawer and varus test using Telos device. The clinical results were graded according to the VAS and AOFAS scale. Results: VAS score improved from preoperative 8.2 points to 3.1 points. There were 38 patients who were excellent (above 90 points), 18 who were good (between 76 and 90 points), 5 who were fair (between 60 and 75 points), and 1 who was poor (below 60 points) according to the AOFAS ankle and hindfoot scale. The excellent and good results amounted to 90.3%. Conclusion: Surgical reconstruction of lateral capsule-ligament complex with reinforcement by periosteal flap of distal fibula and inferior extensor retinaculum is believed to be a effective method for chronic lateral ankle instability.

        • SCOPUSKCI등재

          Lactobacillus casei Phage J1 Genome의 Cohesive End Site 염기배열

          김영창,성학모,강현삼,Kim, Young-Chang,Seong, Hark-Mo,Gang, Hyeon-Sam 한국미생물학회 1994 미생물학회지 Vol.32 No.3

          Lactobacillus casei에 감염하는 bacteriophage J1 게놈의 cohesive end site (cos)의 염기배열을 결정하였다. 또한 환형 cos와 선형 J1 DNA의 왼쪽 말단 염기배열을 비교한 결과 terminase가 절단하는 위치는 다음과 같았다. 5'- GGTCGGCC$\downarrow$ -3' 3'- $\uparrow$CCAGCCGG -5' J1 게놈의 cohesive end는 3' 말단이 돌출되어 있으며 8개의 뉴클레오티드로 이루어져 있고 G+C 함유율이 87.5%이었다. cos 부위는 선형 DNA의 왼쪽 5' 말단 뉴클레오티드의 위치를 +1로 정하였을 때 -33부터 +25까지 대칭이었다. 지금까지 보고된 phage들의 cos 부위 사이에 상동성은 발견되지 않았다. The nucleotide sequence of the cohesive end site (cos) of Lactobacillus casei phage J1 genome was determined. Comparison between the nucleotide sequences of the circular cos and the left end of the linear J1 DNA showed that the nicking sites of the terminase were as follows: 5'- GGTCGGCC$\downarrow$ -3' 3'- $\uparrow$CCAGCCGG -5' The cohesive single-stranded ends of J1 were found to be 3'-protruding and composed of 8 nucleotides. The mol% G + C of the cohesive ends was 87.5. The cos site shows dyad symmetry from -33 to + 25 bp if the 5' terminal nucleotide of the left end of the linear J1 DNA is numbered +1. No homology was found among the cos sites of phages reported so far.

        • KCI등재

          우리나라 인삼 육종의 주요 성과와 전망

          방경환(Kyong-Hwan Bang),김영창(Young-Chang Kim),이정우(Jung-Woo Lee),조익현(Ick-Hyun Cho),홍지은(Chi-Eun Hong),현동윤(Dong-Yun Hyun),김장욱(Jang-Uk Kim) 한국육종학회 2020 한국육종학회지 Vol.52 No.S

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          Artificial selection of ginseng has been practiced since Hwangsook (with yellow pericarp and a green stalk, and was developed from a landrace parent) and Cheonggyeong (with red pericarp) were selected as breeding lines in 1926. Systematic research into ginseng breeding, however, started in earnest in the 1960s when the Central Research Institute of Monopoly and Technology (CRIMT) was established, and the Korean Ginseng Experiment Station was organized under the CRIMT. Research into variant characteristics, resource collections, and genetic evaluations began around this time. With the establishment of the Korean Ginseng Institute in the 1970s, studies involving pedigree selection, cataloguing of agricultural traits of genetic resources, generation shortening by tissue culture, and heritability assessments were conducted. In the 1980s, regional adaptation tests were carried out on breeding lines, focusing on ginseng-producing districts. In the 1990s, research was performed on seed multiplication for variety diffusion, effective components and processing quality, and cross breeding. Foreign ginsengs were introduced for interspecies hybridization, and studies were conducted using genetic engineering techniques. Since the 2000s, applications have been made to patent different ginseng cultivars. Currently, 32 cultivars are registered at the Korea Seed & Variety Service. Future goals for ginseng breeding include developing climate change- and disaster-resistant, consumer-oriented, high-performance cultivars. Therefore, it is necessary to develop technologies for distributing new cultivars by collecting and evaluating genetic resources, and cross breeding and performing mass propagation using these resources.

        • KCI우수등재

          인삼 종자의 개갑률 향상을 위한 적정 수확시기 및 GA₃ 처리 효과

          김영창(Young Chang Kim),김영배(Young Bae Kim),박홍우(Hong Woo Park),방경환(Kyong Hwan Bang),김장욱(Jang Wook Kim),조익현(Ick Hyun Jo),김기홍(Ki Hong Kim),송범헌(Beom Heon Song),김동휘(Dong Hwi Kim) 한국약용작물학회 2014 韓國藥用作物學會誌 Vol.22 No.6

          This study was performed to identify optimal harvesting time of ginseng seeds and to examine the effect ofGA₃ treatment for improvement of seed stratification rate. Ginseng seeds harvested from Land race, Chunpoong and Yunpoongcultivar in July 20 were tested for stratification rate. It was shown that stratification rates of land race, Yunpoong andChunpoong cultivar were 94.1%, 93.1%, and 82.6%, respectively. Seeds of Chunpoong cultivar harvested 10-15 days latershowed a comparable stratification rate to that of Land race, indicating that late harvest of Chunpoong seeds is beneficialfor the increase of stratification rate. The higher stratification rate was found in mature seeds (92.3%) than immature seeds(37.8%), both of which were harvested in July 20. Stratification rate of mature seeds harvested in July 15 was 87.5%, demonstratingoptimal harvesting time of ginseng seeds with higher stratification rate is after mid-July. An exponential growthof endosperms of ginseng seeds was observed from early June to mid-June and then slow growth was observed. There wasno obvious growth of embryos from fertilization to mid-August. After the this time, embryos quickly grew until late October. Thus, appropriate stratification control is essential during the period (from early September to late October) in order tooptimize embryo growth and development. While no increase of stratification rate was observed in seeds treated with50 ppm of GA₃, significant increases were observed in seeds treated with 100 ppm of GA₃. At this concentration of GA₃, thestratification rate of Land race, Chunpoong and Yunpoong cultivar was 95.0%, 95.3%, and 96.5%, respectively.

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