간장 ( 肝臟 ) 및 담도 ( 膽道 ) : 광주 · 전남 지역의 초 · 중 · 고등학생 173 , 342명에 있어서 HBsAg 및 anti - HBs 양성률에 관한 연구

정남기(Nam Ki Joung),오은아(Eun A Oh) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.4

N/A To investigate the positive rates of HBsAg & anti-HBs in Kwangju city & Chonnam province, we surveyed a total of 173,342 students, 48,711 primary, 41,988 middle & 82,637 high school students. The results were as follows: 1) Among 173,342 cases, 9,137 (5,27%) were positive for HBsAg and 38,725 (22.34%) were positive for anti-HBs. 2) HBsAg was positive in 2,034 (4.18%) of 48,711 primary school children, 2,112 (5.03%) of 41,988 middle school students and 4,993 (6.04%) of 82,637 high school students. HBsAg positivity increased signifiantly witb age (p<0.001). Anti-HBs positivity frequency of 48,711 primary school children was highest (12, 359, 25.379o) ~nnd of next 41,~98~8 middle school students (10,251, 24.41%) and of 82,637 high school students (16,115, 19.50%) was in order of frequency. The positive rate of anti-HBs was signifacantly reIated to age (p< 0.001). 3) 124,625 middle & high school students included 76,817 male students and 47,808 female students. The positivity of HBsAg was 4,980 (6.48%) and the positivity of anti-HBs was 15,638 (20.3896) in 76,817 male students Among 47,808 female students, 2,125 (4.44%) females were HBsAg positives and 10,708 (22.39%) females were anti-HBs positives. HBsAg poaitivity was significantly higher in male than in female (p<0.001) while anti-HBs poeitivity waa significantly higher in female than in male (p<0.001). In coaclusion, HBsAg positivity showed increase with age and was higher in male than in female. The positive rate of anti-HBs was significantly related to age and was significantly higher in female than in male.

간장 ( 肝臟 ) · 담도 ( 膽道 ) 및 췌장 ( 膵臟 ) : HBeAg 보균자 , 정상성인 그리고 각종 간질환에서 혈청 Ferritin치에 관한 연구

정남기(nam Ki Joung),심승식(Seung Sik Shim) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.4

N/A In order to compare serum ferritin levels in each groups, the serum ferritin and serum transaminase were measured in 38 normal adults, and 50 patients with HBeAg carriers, 253 patients of various liver diseases (31 patients with acute hepatitis, 80 patients with chronic hepatitis, 119 patients with liver cirrhosis, 23 patients with hepatoma) who were admitted to St. Columban hospital from January 1989 to December 1989. Then we evaluated the relationship of serum ferritin levels in each groups. The following results were obtained. 1) The serum ferritin levels in 38 normal adults were 225 +- 71.06 ng/ml, and 215.50 +- 63.26 ng/ml in HBeAg carriers, but there was no correlatin in two groups. 2) Ferritin levels in each disease groups were higher than normal adults except acute hepatitis and that of liver cirrhosis was significantly elevated (p<0.01). 3) There was no significant correlation in the levels of serum ferritin with the serum ALT activities. 4) Serum ALT was significantly elevated in HBsAg positive patients than HBsAg negative patients in each liver diseases. In conclusion, there was no significant elevation of serum ferritin levels in HBeAg carriers compared with non-carriers.

간장및 담도 : 산모와 신생아에서 C형간염바이러스의 수직감염에 관한 연구

정남기(nam Ki Joung),장영호(Yung Ho Chang),유영근(Young Geun Ryoo),정만(Mann Jung),심승식(Seung Shik Shim),오은아(Eun A Ho) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.2

N/A In order to confirm the perinatal transmission of hepatitis C virus from pregnant women to newborn infants, anti-HCV was tested in 45 pregnant women and their 46 newborn infants who were negative for HBsAg and IgM anti-HA and who showed elevated ALT in more than 2 follow-up tests. The results were as follows; 1) The mean age of 45 pregnant women was 26.8. There was no significant relationship between epidemiologic factors and elevated ALT in pregnant women. 2) Among 45 HBsAg and IgM anti-HA negative pregnant women, 22 were anti-HBs and anti-HBc positive, 14 were anti-HBc positive only, and 9 were anti-HBs and anti-HBc negative. The degree of abnormal ALT in mothers and infants was unrelated to the hepatitis B viral markers in mothers. There was no significant relationship in the degree of ALT elevation between mothers and infants. 3) Anti-HCV was positive in 7 cases (15.6%) of 45 pregnant women. Anti-HCV was positive in 6 cases (15.2%) of 46 newborn infants. In the 7 anti-HCV positive mothers, anti-HCV was positive for one year or a maximum of four years and ALT was elevated intermittently for more than one year, the same as chronic viral hepatitis. But in the 6 cases of anti-HCV positive infants, anti-HCV disappered within 6 or 12 months in most cases and ALT elevation didnt continue for more than 6 months. 4) Anti-HCV was positive in 4 cases (50%) of 8 newborn infants of anti-HCV positive mothers (p< 0.01). Anti-HCV was positive in 2 (67.7%) of 3 cases whose blood was drawn and stored immediately after birth. The positive rate of anti-HCV was about 15% in 45 pregnant women and their infants who were NANB hepatitis suspects by surrogate tests. Anti-HCV was positive in 50% and ALT was abnormal in all eight infants of chronic HCV carrier mothers. We confirmed the passive transfer of anti-HCV from mother to infant. But we need more evidence to confirm the perinatal transmission of HCV.

간장 및 담도 : 산모와 신생아에서 B 형 간염표식자에 (肝炎標識子) 관한 연구

박광숙(Kwang Sook Park),최관수(Gwan Su Choi),정원재(Won Jae Jeong),김지운(Ji Woon Kim),정남기(nam Ki Joung),장영호(Yung Ho Chang) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.1

N/A To analyze frequency and severity of liver disease in 3rd trimester and full term Korean pregnant women, to observe the prevalence of HBV markers in pregnant women and newborn infants at delivery and to evaluate the effect of HBV on fetus, newborn infants and pregnant women. We received the findings of the physical examination and history taking, and did SGPT and HBV markers with EIA method at intervals in 2,873 pregnant women who delivered at St. Columbans Hospital in Mokpo City from April 1st, 1985 to March 31st, 1986. The following results were obtained: 1) The overall HBsAg positivity in all 2,873 pregnant women was 8.3% 2) Among 2,873 pregnant women, 5 cases in 3rd trimester and 6 cases in full-term pregnant women showed typical acute viral hepatitis B and most of them were normal in their follow-up tests. 32 cases who shoWed mild elevation of SGPT were normal in their follow-up tests. But it was difficult to differentiate between a course of acute or chronic hepatitis and mild liver dysfunctions during pregnancy. 3) Among 195 HBsAg positive pregnant women, 76 cases(39.0%) were HBeAg positive, 65 cases(33.3%) were HBeAg negative and 54 cases(27.7%) were Anti-HBe positive. 4) Mother to infant transmission of HBV markers at delivery was as follows: Positive rate of HBsAg was 10.0% or 14 infants in 140 pregnant women. Positive rate of HBeAg was 17.8% or 8 infants in 45 cases. Positive rate of anti-HBs was 88.9% or 16 infants in 18 cases. Positive rate of anti-HBc was 96.2% or 125 infants in 135 cases. Positive rate of anti-HBe was 100% or 35 infants in 35 cases. 5)We evaluated the HBV markers in newborn infants 3 groups according to the maternal HBeAg/Anti-HBe status at delivery in 107 HBsAg positive pregnant women. Out of 38 HBeAg positive women, 6 infants(15.8%) were positive for HBsAg and HBeAg, 31 infants (81.6%) were negative for HBsAg, HBeAg and anti-HBe. Out of 39 HBeAg reative women, 2 infants(5.1%) were positive for HBsAg and negative for HBeAg, 31 infants(79.5%) were negative for HBsAg, HBeAg and anti-HBe. Out of 30 anti-HBe positive women, 3 infants (10.0%) were positive for HBsAg and anti-HBe, negative for HBeAg, 22 infants(73.3%) were negative for HBsAg and HBeAg, positive for anti-HBe. HBV markers in newborn infants corresponded to their mothers degree of infection. 6) Among 2,873 pregnant women, vve found 135 cases of prematurity, 6 cases of still birth cases of intrauterine death, 56 cases of congenital anomaly and 122 cases of severe physiologic jaundice. We also found in the past history 75 cases of prematurity, 18 cases of stillbirth, 36 cases of intrauterine death, 14 cases of congenital anoma!y, 34 cases of infantile death and 444 cases of spontaneous abortion. There was no significant incrcase in frequency of adverse effects of HBV according to the mothers HBsAg positivity status. 7) Positive rate of HBsAg was 16.4% in 61 cases who showed toxemia of pregnancy. Positive rate of HBsAg was 8.1%. In 2, 812 cases who showed no toxemia of pregnancy. There was significant increase of toxemia of pregnancy in HBsAg carrier(0.01<P<0.025). Positive rate of HBsAg was 14.7% in 109 cases who bled more than 500 cc postpartum hemorrhage. Positive rate of HBsAg was 8.1% in 2812 cases who bled less than 500cc postpartum hemorrhage. There was significant increase of postpartum hemorrhage in HBsAg carrier(0.01<p<0.005). Severity of hyperemesis was unrelated to HBsAg positivity. 8) We observed the course and severity of hepatitis during pregnancy. Among 5 cases in 3rd trimester and 6 cases in full term pregnant women, only one case showed elevation of SGPT for more than 6 months. Among 19 non-pregnant women, one case in 15 patients of acute viral hepatitis and 3 cases in 4 patients of chronic viral hepatitis showed elevation of SGPT for more than 6 months. There was no significant difference in couse, severity and prevalence of HBV markers between pregnant and non-pregnant women.

목포지역에서의 B 형 간염 (肝炎) 바이러스 감염요인에 (感染要因) 관한 역학적 연구

박광숙 ( Kwang Sook Park ),김지운 ( Ji Woon Kim ),최관수 ( Gwan Su Choi ),정원재 ( Won Jae Jeong ),정남기 ( nam Ki Joung ) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.2

N/A We tested 1389 pregnant women for HBsAg and 197 pregnant women for anti-HBs, anti-HBc, HBeAg and antiHBe with EIA method. 1) The occurance rate of HBsAg was 8.8Yo in a total of 1389 cases. 2) The occurance rate of HBsAg was unrelated with age, because it was the lowest in the age group of 21-30 years(7.9%) and much higher in the age group of below 20 years (16.0%) and over 30 years(15.3%). 3) The occurance rate of HBsAg was related a little with locality. It was slightly higher in cases from the city(9.3% than in cases from the village(8.5%). 4) The occurance rate of HBsAg was unrelated to educational background. 5) The occurance rate of HBsAg was increased in groups with an income of 400,000-500000 won(10.3%) and over 500,000 won(13.1%) than in groups with smaller income. 6) The effect of family history of liver disease: The occurance rates of all hepatitis B viral markers were increased in those who had a family history of liver disease, but the occurance rates of HBsAg(p<0.005%, antiHBs(p<0.005) and antiHBc(0.025<p<0.01) were increaed significantly. 7) The effect of acupuncture: The occurance rates of HBsAg and HBeAg were increased significantly in those who had a history of acupuncture(p<0.005, 0.025<p< 0.01), but te occurance rates of anti-HBs and antiHBe were decreased. 8) The occurance rate of antiHBs was increased significantly in student nurses(p. 6i) and graduate nurses(58.0%) compared to university students(27.7%)(p<0.005). The occurance rate of anti-HBc was increased but not significantly(0.05<p<0.1), but there was no Significant difference between each year by duration of exposure in hospital work. The occurance rate of HBsAg was not related in the three groups.

B 형 간염 백신의 효과 - 산모의 HBeAg 양성 유무에 따라 -

김세종(Sei Jong Kim),윤종만(Chong Mann Yoon),최관수(Gwan Su Choi),김지운(Ji Woon Kim),정남기(nam Ki Joung),장영호(Yung Ho Chang),오은아(Eun A O),양인애(In Ae Yang),유영근(Young Geun Ryoo),이봉섭(Bong Seob Lee) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.1

N/A The preventive efficacy for HBV infection and chronic HBV carrier rate by active and passive immunoprophylaxis was observed in 49 newborn infants whose mothers were healthy HBV carriers with normal ALT activity at delivery. All infants were divided into 3 groups; Group A received HBIG at birth and HB Vaccine (Hepavax- B) at month 0, 1 and 6. Group B received first or second vaccine only. Group C received no vaccine. ALT activity, HBsAg and anti-HBs were tested every 3 months for 18 rnonths after delivery, and the results were analyzed in 3 groups according to the mothers HBeAg positivity. 1) The anti-HBs response was57.1% (16/28) in Group A and 76.9% (10/13) in the control group whose mothers vere normal. The anti-HBs response was 64.3% (9.14) and 57.1% (8/14) according to the mothers HBeAg positivity and negativity. The anti-HBs response was 56.3% (9/16) in male and 66.7% (8/12) in female infants. The anti-HBs response svas higher in female infants and infants a hose mothers were normal or HBeAg positive carriers. 2) Chronic HBV carrier rate in infants of HBeAg positive mothers was 14.3% (2/l4) in Ciroup A, 72.7% (8/11 ) in Group 8, 100% (6/6) in Group c and was statistically significant (p=0.037) (c=0.816). There was no significant difference hetween group A, B, and C in infants of HBeAg negative mothers. 3) The positive rate of HBsAg showed significant difference between Groups A and B, A and C, A and (B+C), (A+B) and C in all 3 monthly follow-up tests in infants of HBeAg positive mothers. But there was no significant difference between (groups A, B, and C in infants of HBeAg negative mothers. The results suggest that the anti-HBs response was lower in infants of HBsAg carrier mothers. The preventive efficacy of vaccine for HBV infection and chronic HBV carrier rate was excellent in infants of HBeAg positive mothers but not significant in infants of HBeAg negative mothers by the active and passive immunoprophylaxis.

진폐증이 동반된 공피증 1 예

박광숙,장영호,김지운,최관수,정남기,정원재 대한내과학회 1986 대한내과학회지 Vol.31 No.2

Scleroderma is a multisystem and multistage disorder charaterized proliferative vascular lesions, obliterative microvascular lesions, and residual atrophy with fibrosis of skin and internal organ, with variable duration and prognosis. A 39 year-old male patient who had coal miner's pneumoconiosis was admitted to our hospital because of numbness of fingers, digital pitting scar and difficulty of mastication for 4 years. So we report this case of scleroderma associated with pneumoconiosis after laboratory, radio- logic study and skin biopsy with review of the literatures.