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항호중구 세포질항체와 연관이 있는 혈관염에서 동반된 다발성 단신경염(Mononeuritis Multiplex) 1 예-ANCA(+) Mononeuritis Multiplex-
김권삼,강흥선,임천규,김명식,류혜영,손경환,이무열,정경천,성동욱,구혜수 대한내과학회 1996 대한내과학회지 Vol.51 No.5
Mononeuritis multiplex is known to occur in many illness including certain types of systemic vasculitis, ANCA has been described in association with Wegener's granulomatosis, polyarteritis nodosa, and pauci-immune necrotizing crescentic glomerulonephritis, since it was first reported in 1982 by Davis et al in patients who had necrotizing glomerulonephritis with no immune deposits. ANCA may well be useful in distinguishing cases mediated by vasculitis from those produced by other processes, especially early in the course of a disease. We report a case of mononeuritis multiplex due to ANCA associated vasculitis. We diagnosed vasculitis neuropathy by sural nerve biopsy and angiography. The patient was treated with prednisolone and oral cyclophosphamide. Her subjective symptoms and objective signs were improved. Subsequent examination of ANCA was negative.