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Angiotensin 2 수용체 길항제 투여가 Cyclosporine 신독성에 의한 염증반응에 미치는 영향
송준창 ( Joon Chang Song ),신미정 ( Mi Jung Shin ),전연주 ( Yeon Joo Jun ),우성용 ( Seong Yong Woo ),형복진 ( Bok Jin Hyoung ),윤혜은 ( Hye Eun Yoon ),우현영 ( Hyun Young Woo ),최범순 ( Beum Soon Choi ),양철우 ( Chul Woo Yang ) 대한내과학회 2004 대한내과학회지 Vol.67 No.6
목적 : 신장 이식시 투여되는 cyclosporine (CsA)은 우수한 면역 억제제이지만 장기간 투여로 세뇨관 간질 섬유화와 염증반응을 유발한다. 만성 CsA 신독성 병태생리는 다양하게 제시되고 있으며 이중 레닌-안지오텐신계의 활성화가 중요한 역할을 하는 것으로 보고 되고 있다. 이에 본 연구에서는 안지오텐신 Ⅱ 수용체 길항제인 losartan (LSRT) 투여가 CsA에 의한 신장내 염증반응을 억제하는지 세뇨관 간질 섬유화와 대식세포 침윤의 지표인 Background : Long-term treatment of immunosuppresant CsA causes interstitial inflammation and fibrosis in the kidney. Renin-angiotensin system (RAS) plays the most important role in the pathogenesis CsA-induced renal injury. Accordingly we evaluated the a
주의력결핍 과잉행동장애와 스마트폰 중독, 우울, 불안, 자존감
이효철(Hyo Chul Lee),홍민하(Min Ha Hong),오창근(Chang Keun Oh),심세훈(Se Hoon Shim),전연주(Yeon Joo Jun),이석범(Seog Bum Lee),이경규(Kyung Kyu Lee),백기청(Ki Chung Paik),백혜순(Hea Soon Baek),임명호(Myung Ho Lim) 대한소아청소년정신의학회 2015 소아청소년정신의학 Vol.26 No.3
Objectives:The current study investigated the risk of smartphone addiction among children and adolescents with or without attention-deficit hyperactivity disorder (ADHD), risk of depression, anxiety, and self-esteem using the Smartphone Addiction Scale Proneness, Kovac’s Children’s Depression Inventory, State-Trait Anxiety Inventory, and Rosenberg Self-Esteem Scale, commonly used in clinical medicine. Methods:Ninety five students with ADHD who visited psychiatry outpatient clinics completed the questionnaire. At the same time, 592 middle and high school students living in a similar area regardless of ADHD diagnosis, completed the questionnaire as control subjects. Results:Overall, 40.0% of 95 ADHD and 12.8% of 592 control subjects were classified as the smartphone addiction proneness group, 26.3% of the ADHD subjects and 8.3% of the control group were classified as the depression group, and 32.6% of the ADHD subjects and 16.2% of the control group were classified as the anxiety group. Significant differences were observed between the two groups. Conclusion:The results of this study suggest that ADHD subjects are more prone to smartphone addiction, becoming depressed or anxious than those in the control group. From this study, we could suggest that students with ADHD are more easily affected by smartphone addiction than normal control subjects. In addition, we might understand how some psychiatric problems like depression, anxiety, and low self-esteem are related to ADHD and smartphone addiction.