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ICR 마우스를 이용한 평위산과 발효평위산 급성독성 연구
장두례 ( Doo Rye Jang ),황윤환 ( Youn Hwan Hwang ),정기연 ( Ki Youn Jung ),하정호 ( Jeong Ho Ha ),박화용 ( Hwa Yong Park ),마진열 ( Jin Yeul Ma ) 대한한방부인과학회 2013 大韓韓方婦人科學會誌 Vol.26 No.1
Objectives: This study was conducted to investigate the acute toxicity of Pyungwi-san (Pingwei-san in Chinese) in ICR mice, according to KFDA and OECD guideline. Methods: In the present study, 15 male and female ICR mice administrated singly by gavage at dose levels of 0 and 2000 mg/kg of Pyungwi-san. During the experimental period, no treatment-related death was observed. There were no adverse effects on clinical signs, body weight, and gross findings at all treatment groups. Results: These results showed that the single oral adminstration of Pyungwi-san (Pingwei-san) did not cause any toxic effect at the dose levels of 2000 mg/kg in rats. Conclusions: Taken together, the median lethal dose (LD50) of Pyungwi-san (Pingwei-san) was considered to be over 2000 mg/kg body for both sexes.
박화용,황윤환,장두례,하정호,정기연,마진열,Park, Hwayong,Hwang, Youn-Hwan,Jang, Doorye,Ha, Jeong-Ho,Jung, Kiyoun,Ma, Jin Yeul 대한한의학방제학회 2012 大韓韓醫學方劑學會誌 Vol.20 No.2
Objectives : Traditional medicine Gumiganghwal-tang (GT) has been used in Asia to treat inflammatory diseases including common cold, pain, fever, and algor. In this study we investigated the acute toxicity and safety of GT and fermented GT (FGT). Methods : Acute toxicity and safety were evaluated in male and female ICR mice orally administered 0 (control) and 2,000 mg/kg of GT and FGT. After the administration of GT and FGT, we observed mortality, body weight, clinical symptoms. After necropsy, organ weights were measured and blood analysis was performed. Results : There was no mortality and clinical symptoms according to the administration of GT and FGT. Comparing with control group, there were no significant alterations on the organ weight, complete blood cell count and biochemical parameters. Conclusions : Median lethal dose of GT and FGT considered to be over 2,000 mg/kg in both male and female mice, and recognized as safe with no toxicity.
ICR 마우스를 이용한 팔물탕 및 발효팔물탕의 급성독성 연구
정기연,황윤환,장두례,하정호,마진열,Jung, Kiyoun,Hwang, Youn-Hwan,Jang, Doorye,Ha, Jeong-Ho,Ma, Jin Yeul 대한예방한의학회 2013 대한예방한의학회지 Vol.17 No.1
Objectives : This study was carried out to investigate the acute toxicity and safety of Palmultang and Fermented Palmultang Extract in Mice. Methods : To evaluate their acute toxicity and safety, 0 (control group), 2000 mg/kg of Palmultang and Fermented Palmultang Extracts were orally administered to 15 male and 15 female ICR mice. After a single administration, we observed survival rates, behavioral pattern, clinical sign, body weight. The results of biochemical analysis and hematological analysis were no any significant change. Results : Compared with the control group, we could not find any toxic alteration in all treated mice. Conclusions : Overall, the results suggest that, the oral administration of Palmultang and Fermented Palmultang extracts did not produce significant toxic effect in mice. Hence, the fermented extract can be utilized for herbal therapy.