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임군일,권오진,김장희 대한정형외과학회 2014 Clinics in Orthopedic Surgery Vol.6 No.4
Background: The relationship between osteoarthritis (OA) and osteoporosis (OP) is complicated and it may differ according to the site or stage of disease. The purpose of this cross-sectional study is to examine the relationship between the severity of radiological knee OA and the degree of OP in the ipsilateral proximal femur as denoted by bone mineral density (BMD) in a Korean population, especially among women. Methods: One hundred ninety-five female patients who had knee pain and radiological knee OA were investigated with respect to the relationship of knee OA severity with BMD. The BMD of the proximal femur and spine was measured by dual energy X-ray absorptiometry, and the severity of knee OA was evaluated based on Kellgren-Lawrence (K-L) radiographic criteria, joint space narrowing (JSN) and mechanical axis of knee alignment. Partial correlation analysis and ANCOVA adjusted for confounding factors (age and body mass index) were performed to assess the relationship. Results: There was a statistically significant relationship between the BMD of the proximal femur and JSN, and the BMD of the proximal femur was positively associated with increased joint space width. There was a lack of association between the spine BMD and JSN. The BMD of the proximal femur was also significantly lower in patients who had a higher K-L grade. Conclusions: The radiographic finding of severe OA in the knee is associated with decreased BMD of the ipsilateral proximal femur including the femoral neck, trochanter, intertrochanter, and region of the entire hip (neck, trochanter, and Ward’s triangle).
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인공관절 주위의 골용해: 마모입자에 대한 생물학적 반응
임군일 한국생체재료학회 2007 생체재료학회지 Vol.11 No.2
Although total hip arthroplasty is one of the most successful reconstructive procedure, periprosthetic osteolysis caused by the biological reaction to particulate wear debris poses the greatest challenge to the long-tem survival of the implanted prosthesis. In this review, the pathogenesis of and the pharmacological attempts to treat the biological reaction are outlined.
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The Concept of Early Osteoarthritis and Its Significance in Regenerative Medicine
임군일 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.3
Osteoarthritis (OA) has been investigated as one of important target diseases for regenerative medicine. The concept of early OA has recently emerged under the assumption that if OA is detected and intervened early, progression of OA might be arrested or delayed before irreversible destruction of the joint occurs. This concept also matters in regenerative medicine for OA because new regenerative technologies can work better when joint damage is minimal. Diagnostic criteria for early OA have been suggested in this background to find a group of patients who have a higher possibility of developing full-blown OA. However, as currently suggested criteria of early OA are mostly expert opinions lacking higher level of evidence, clinical validations are necessary to prove their value in patient care. While new treatment methods that can suppress or prevent symptoms at an early stage of OA before progressive and irreversible changes occur are being developed, detailed definition and classification of early OA agreed upon by major stakeholders in OA field and validated by prospective studies are necessary to prove the efficacy of these methods. As clinical outcome of regenerative treatment is related to patient characteristics and the status of the whole joint, it is of critical significance to predict which patient will progress and who will be responsive to regenerative treatment. While diagnostic criteria for early OA should be highly sensitive and applicable without employing biomarkers or magnetic resonance imaging, a subclassification and comprehensive endotyping /phenotyping using these techniques might be needed to detect the population who would be responsive to regenerative medicine.
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임군일 한국생체재료학회 2008 생체재료학회지 Vol.12 No.2
Wear particles generated from artificial joints cause biological reactions which usually lead to periprosthetic osteolysis. As the longevity of joint replacement is generally determined by the presence and progression of osteolysis, the strategy to prevent the complication is of utmost importance in joint replacement surgeries. Although macrophages are the main target of wear particles, bone forming cells and their progenitors are also directly affected by them. In this review, the results of investigations that have studied the effects of various particles on osteoblasts and menchymal stem cells are summarized.
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Biomaterials in orthopaedics: the past and future with immune modulation
임군일 한국생체재료학회 2020 생체재료학회지 Vol.24 No.1
Orthopaedics owes its current status of advanced care to the development of biomaterial science more than any other clinical medical specialty. The purpose of this brief review is to introduce the history and present status of biomaterials in orthopaedic field and cast a perspective on the future use of biomaterials to treat musculoskeletal disorders with particular emphasis on immune modulation. While the biomaterials in orthopaedics started from inert materials to replace the function and structure of hard tissue such as bone and cartilage, regenerative medicine will play a greater role in preventing the traumatic loss of tissues, as well as in the earlier stages of diseases. The understanding and modulation of immune response to biomaterials will further lead to the better incorporation of implants into host tissue or the near-perfect regeneration of host tissue.
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임군일 한국생체재료학회 2006 생체재료학회지 Vol.10 No.4
Reconstruction for large bone defect poses great challenge for orthopaedic surgeons. Allograft is usually required, but it has several drawbacks including high cost, infection, disease transmission and lack of incorporation inside the host bone. Recent surge in stem cell research also brought forth the possibility of treating bone defect with tissue-engineered bone. In this review, recent updates on the bone regeneration using mesenchymal stem cells are briefly summarized along with the established concepts of bone regeneration.
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임군일 한국생체재료학회 2006 생체재료학회지 Vol.10 No.1
Mesenchymal stem cells (MSCs) exist in bone marrow and other musculoskeletal tissues. These cells contribute to the homeostasis of musculoskeletal tissue as well as support for the growth and differentiation of primitive hemopoietic cells. Recent advancements in tissue engineering and regeneratve medicine have brought MSCs to high attention as a potential source of cells which would differentiate to a variety of tissue, tailored to individual needs. In this review is briefly outlined the current status of MSCs, particularly focused on their biological characteristics
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