Telomere Length of Tumor Tissues and Survival in Patients with Early Stage Non-Small Cell Lung Cancer

이용훈,( Hyo Sung Jeon ),( Eung Bae Lee ),( Seung Soo Yoo ),( Shin Yup Lee ),( Jaehee Lee ),( Seung Ick Cha ),( Chang Ho Kim ),( Jae Yong Park ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.0

Introduction: Telomere shortening leads to genomic instability that drives oncogenesis through the activation of telomerase and the generation of other mutations necessary for tumor progression. This study was conducted to determine the impact of telomere shortening on the survival of patients with early stage non-small cell lung cancer (NSCLC). Methods: Relative telomere length in tumor tissues was measured by quantitative polymerase chain reaction in 164 patients with surgically-resected NSCLC. The association between telomere length and overall survival (OS) and disease-free survival (DFS) was analyzed. Results: When the patients were categorized into quartiles based on telomere length, those patients with the 1st quartile (shortest) of telomere length had a significantly worse OS and DFS compared to patients with the 2nd to the 4th quartiles of telomere length (adjusted hazard ratio for OS=2.67, 95% confidence interval=1.50-4.75, p=0.001; and adjusted hazard ratio for DFS=1.92, 95% confidence interval=1.17-3.14, p=0.01). An association between telomere length and survival outcome was more pronounced in squamous cell carcinomas than adenocarcinomas (p-value of test for homogeneity for OS and DFS=0.05 and 0.02, respectively). Conclusion: Telomere length of tumor tissues is an independent prognostic factor in patients with surgically resected early stage NSCLC.

지상파DMB에서 끊김없는 프로그램의 전환을 위한 스플라이서의 설계 및 구현

이용훈,이진환,이광순,이수인,김남,Lee Yong-Hoon,Lee Jin-Hwan,Lee Gwang-Soon,Lee Soo-In,Kim Nam 한국통신학회 2006 韓國通信學會論文誌 Vol.31 No.5a

본격적인 지상파DMB 서비스가 시작됨에 따라, 중앙 또는 다른 방송국으로부터 들어오는 방송신호를 재송신하던 도중에 지방의 방송국에서 필요한 지역광고 및 특정 프로그램을 보내고자 하는 경우에 스플라이싱 기법이 필요하게 된다. 본 논문에서는 MPEG-4 및 MPEG-2 시스템을 동시에 사용하고 있는 지상파DMB에서 효율적인 스플라이싱을 위해 요구되는 신호 흐름에 대해 제안하며, 지상파DMB에서 신호 전송 시 사용되는 앙상블스트림으로의 재구성 과정에 대해 설명한다. 또한, 설계된 DMB 스플라이싱 기술을 적용하여 제작된 스플라이서를 통해서 전송스트림을 스위칭했을 때, 수신기에서 영상을 디코딩하여 비교함으로써 그 성능을 검증하였다. As the T-DMB service is launched, some service requirements become necessary to send local programs such as advertisement and specific programs at the local broadcasting station while re-transmitting the broadcasting signal coming from the central or other station. In this paper, we propose a signalflow required for the effective splicing in the T-DMB system which usesboth MPEG-2 and MPEG-4 system specifications, and we illustrate the reconfiguring process into the ensemble stream that is widely used for the transmission of the T-DMB signal. Moreover, its performance is confirmed by comparing the images decoded at the recevier when the transport stream is swiched by using the splicer implemented through the proposed techniques.

Association between Genetic Variants in Pre-microRNAs and Survival of Early Stage Non-small Cell Lung Cancer

이용훈,( Mi Jeong Hong ),( Shin Yup Lee ),( Seung Soo Yoo ),( Jae Hee Lee ),( Seung Ick Cha ),( Chang Ho Kim ),( Eung Bae Lee ),( Hyo Sung Jeon ),( Ji Woong Son ),( Jae Yong Park ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

Introduction: Altered miRNA expression plays an important role in the initiation and progression of lung cancer. Single nucleotide polymorphisms (SNPs) in pre-miRNAs could alter miRNAs processing, or expression, and hence, could influence the prognosis of lung cancer. We evaluated the effects of four SNPs in pre-miRNAs (pre-miR-146a rs2910164, pre-miR-149 rs2292832, pre-miR-196a rs11614913, and pre-miR-499 rs3746444) on the survival outcomes in early-stage NSCLC. Methods: Surgically resected 363 NSCLC patients were enrolled. The four SNPs were genotyped using a PCR-RFLP assay. The genotype associations with overall survival (OS) and disease free survival (DFS) were analyzed. Results: The pre-miR-149 rs2292832T>C and pre-miR-196a rs11614913C>T were found to be significantly associated with OS and DFS. The rs2292832 TC or CC genotype exhibited a significantly better OS and DFS compared to the rs2292832 TT genotype (adjusted hazard ratio [aHR] for OS=0.66, p=0.01; and aHR for DFS=0.64, p=0.004). For the pre-miR-196a rs11614913C>T, patients with the CT or TT genotype had a significantly better OS and DFS than those with the CC genotype (aHR for OS=0.70, p=0.05; and aHR for DFS=0.66, p=0.01). When the two SNPs were combined, OS and DFS improved in a dose-dependent manner as the number of good genotypes increased (p=0.002; p=0.0001). Conclusions: These results suggest that miR-149 and miR-196a may be involved in the pathogenesis of NSCLC and that rs2292832 and rs11614913 can be used as prognostic markers for patients with surgically-resected early stage NSCLC.

지상파DMB 제한수신 시스템의 효율적인 설계 및 구현 방법

이용훈,이진환,이광순,이수인,김남,Lee, Yong-Hoon,Lee, Jin-Hwan,Lee, Gwang-Soon,Lee, Soo-In,Kim, Nam 한국통신학회 2006 韓國通信學會論文誌 Vol.31 No.10A

본격적인 지상파DMB 서비스가 시작되면서 사업자별로 다양한 데이터 서비스를 준비하는 등 비즈니스 모델 개발에 주력하고 있다. 이에 따라 DMB에 적합한 제한수신 시스템의 필요성이 이슈화되면서 국내에서는 현재 표준화 작업이 활활발히 진행되고 있다. 본 논문은 지상파DMB 방송환경에서의 적용을 목적으로 하는 지상파DMB 제한수신 서비스를 위한 앙상블 재다중화기와 수신 검증 플랫폼의 설계 및 구현 방법에 관해 제안한다. 또한 제안된 앙상블 재다중화기를 통하여 스크램블링된 앙상블 스트림을 송출하고, 수신검증 플랫폼을 통하여 적용된 스크램블 모드에 따라 디스크램블링 및 디코딩하여 이를 디스플레이 함으로써 그 성능을 검증하였다. As the Terrestrial DMB(T-DMB) has been launched, service providers are focusing on finding a business model as well as preparing the variety of data services. So, the need for development of the CAS(Conditional Access system) is urgently required and its domestic standardization is also in progress. This Paper proposes design and implementation methods of an Ensemble Re-multiplexer and receiver platform for its verification that can be used for the CAS system in T-DMB. And, with transmitting ensemble stream scrambled by the proposed Ensemble Re-multiplexer, we verified their performance by do-scrambling and decoding according to scramble mode at the receiver platform.

LKB1 pathway variant and the prognosis of non-small cell lung cancer after surgical resection

이용훈,( Sook Kyung Do ),( Shin Yup Lee ),( Hyo-gyoung Kang ),( Jin Eun Choi ),( Mi Jeong Hong ),( Jang Hyuck Lee ),( Eung Bae Lee ),( Yangki Seok ),( Ji Yun Jeong ),( Kyung Min Shin ),( Won Kee Lee ),( 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-

This study was conducted to investigate the associations between polymorphisms of genes involved in LKB1 pathway and the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Twenty-three single nucleotide polymorphisms (SNPs) in LKB1 pathway were investigated in a total of 782 patients with NSCLC who underwent curative surgery. The association of the SNPs with overall survival (OS) and disease free survival (DFS) were analyzed. Among the 23 SNPs investigated, TSC2 rs30259G>A was significantly associated with survival outcomes in multivariate analyses. The TSC2 rs30259G>A was associated with significantly worse OS and DFS (adjusted hazard ratio [aHR] for OS=1.88, 95% confidence interval [CI]=1.21-2.91, P=0.005; aHR for DFS=1.65, 95% CI=1.15-2.38, P=0.01, under codominant model, respectively). When stratified by tumor histology, the SNP was significantly associated with survival outcomes only in squamous cell carcinoma, but not in adenocarcinoma. This study suggests that TSC2 rs30259G>A may be useful for the prediction of prognosis in patients with early stage NSCLC after curative surgery.

심근경색후 발생한 심실중격결손의 외과적 치료 -2례 보고-

이용훈,최필조,우종수,Lee, Yong-Hun,Choe, Pil-Jo,U, Jong-Su 대한흉부심장혈관외과학회 1995 Journal of Chest Surgery (J Chest Surg) Vol.28 No.6

Rupture of ventricular septum following myocardial infaction is one of the serious complication of coronary artery disease. The characteristic manifestations are sudden appearance of a harsh systolic murmur, precordial pain, cardiovascular collapse and permit early diagnosis. We report two cases of successful repair of postinfaction ventricular septal defect. The infarcted area was anterior wall of ventricle and VSD was placed near apex of heart in two cases all. VSD was closed with pledgetted Dacron patch and incised wall was sutured with Teflon felt and concomitant coronary artery bypass graft was done respectively .Postoperative courses were uneventful.

30년전 우리는(5) - 1974년 5월

이용훈,Lee, Yong-Hun 한국도서관협회 2004 圖協會報 Vol.45 No.5

성인의 선천성 식도기관지루 3례 보고

이용훈,최필조,우종수,Lee, Yong-Hun,Choe, Pil-Jo,U, Jong-Su 대한흉부심장혈관외과학회 1995 Journal of Chest Surgery (J Chest Surg) Vol.28 No.5

We have experienced three cases of congenital bronchoesophageal fistula which is rare and usually has an insidious clinical course. The patients included a thirty year old man and thirty six, thirty eight year old women respectively. Bronchiectatsis was found in all three cases, and bronchoesophageal fistula was found in one case preoperatively by esophagography and esophagoscopy, and other two cases operative field. The fistula was found between right lower esophagus and right lower lobe in all cases and esophageal diverticulum in one case. So they belonged to type I[1 case , II[2 cases of Braimbridge and Keith`s classification of congenital bronchoesophageal fistula . The fistulectomy was performed in all cases and concomitant lobectomy [2 cases and bilobectomy [1 case were done. There were toxic hepatitis in two cases and prolonged air leakage in one case postoperatively. They were discharged on recovered state and have continued to do well.

30년전 우리는(1) - 1974년 1월

이용훈,Lee Yong-Hun 한국도서관협회 2004 圖協會報 Vol.45 No.1

키케로는 ‘역사는 지나간 시간을 입증하는 목격자다. 즉 역사를 통해 현실을 밝아지고 추억은 생명력을 얻고 일상사의 지침을 제공받으며 태고의 소식들을 전해 받는다’고 했다. 또한 ‘역사는 현재와의 끝임 없는 대화’라고 한 역사가도 있고, ‘역사는 끊임없는 도전과 응전’의 과정이라고 말한 역사가도 있다. 그리고 크로체는 ‘모든 역사는 현대사일 뿐’이라고 했다. 어찌되었든 역사를 모르는 사람이나 민족은 오늘이라고 하는 현실이나 미래를 열어 가는데 있어 바른 방향이나 방법을 제대로 찾기 어렵다는 생각하는 것이 보편적이다. 특히 우리나라에서는 뿌리가 얼마나 중요한가. 자기의 역사를 제대로 아는 것, 그것이 오늘날을 잘 살아가기 위한 첫 번째 조건일 지도 모르겠다. 우리도서관계는 어떨까? 요즘과 같이 세대간의 단절이 점점 심화되는 상황에서 한 도서관 내에서도 직원들 간에 세대 차이를 느끼지 않을 수 없을 것이고, 그러한 세대 차이는 결국 도서관 운영의 합리성이나 직원들간 연대를 저해하는 요소가 될 수 있다. 따라서 세대간 대화의 촉진은 이제 조직의 구성과 운용에 중요한 과제가 되고 있다. 그래서 우리 ‘도서관문화’는 이번 월간으로 전환하는 시점에 지난 한 세대 전 우리 도서관계는 어떠했는지를 되짚어보는 지면을 마련했다. 30년 전후의 도서관 사정을 되짚어보는 것은 그 때의 사정과 정신을 오늘에 되살려, 오늘을 살아가는 우리에게 삶의 지침이 되기를 바라며, 나아가 새로운 미래를 열어 가는데 필요한 정신적 근거를 찾아보고자 한다.

협회행사보고 : 영국 공공도서관 슬라이드 강연회

이용훈,Lee Yong-Hun 한국도서관협회 2003 圖協會報 Vol.44 No.2