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건선 병변에서 Interleukin-8 과 Tumor necrosis factor - α 발현에 대한 면역조직화학적 연구
원덕환(Duck Hwan Won),김영근(Young Keun Kim),최광성(Gwang Sung Choi) 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.5
N/A Background: Psoriasis is a chronic skin disease characterized histologically by prominent keratinocyte hyperplasia and an early inflammatory cell infiltrate. However, the pathogenesis is not fully understood yet. Recently, there has been growing interest in the probable role of a T cell mediated immune response in the pathogenesis. Especially, cytokine network involved in psoriasis has been studied. Objective : This study was done to investigate the role of Interleukin-8(IL-8) and its inducer, Tumor necrosis factor-a(TNF-a) for pathogenesis of psoriasis. Methods: We performed immunohistochemical staining using antibodies for IL-8 and TNF- a in frozen skin samples of 14 psoriatic patients who had not been treated for psoriatic lesion for 1 month and 3 normal skin samples as controls. Results : There was no detectable discrete immunoreactivity for either TNF-a and IL-8 in epidermis and dermis of normal controls. In psoriatic lesions, the expression of TNF-a was found in dermal cells within the papillary dermis, particularly around blood vessels. The expression of IL-8 was presented on suprabasal keratinocytes above TNF- a-positive dermal tissue. Conclusion : Our results strongly suggest that histologic expression and functional interaction between IL-8 and its inducer, TNF- a have significant roles in the pathogenesis of psoriasis.
김영근,구상완,최광성,원덕환,임태균 대한피부과학회 2001 대한피부과학회지 Vol.39 No.7
Rowell's syndrome is believed to be a distinct and rare clinical entity originally described as lupus erythematosus associated with erythema multiforme-like skin lesions, immunologic findings of speckled antinuclear antibodies, anti-La antibodies and a positive test for rheumatoid factor. We report a case of systemic lupus erythematosus in a 31-year-old woman with annular erythematous patches on both hands, feet and back. Also, she presented abnormal serologic and immunologic findings. We believed that our patient meets the criteria for this rarely reported entity.
김영근,이성주,최광성,원덕환,임태균 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.8
Cutaneous bronchogenic cyst is an anomalous structure that arises from the tracheobronchial tree during embryonic development and is usually located in the area of the manubrium sternum or suprastemal notch. Histopathologically, bronchogenic cyst is lined by ciliated pseudostratified columnar epithelia with goblet cells. We report a case of cutaneous bronchogenic cyst in a 25-year-old male patient presented as a nodular lesion on the neck.
김영근,구상완,이주흥,원덕환,반대현,최광성 대한피부과학회 1999 대한피부과학회지 Vol.37 No.11
An intravenous pyogenic granuloma is a rare, benign, intravascular tumor, which arises from the vein wall and protrudes into the lumen. This is characterized by a lobular proliferation of capillaries similar to the more common cutaneous pyogenic granulomas. We report a case of intravenous pyogenic granuloma which showed lobular capillary proliferation in the perivenous connective tissue.
김영근,이성주,구상완,이주흥,최광성,원덕환 대한피부과학회 2000 대한피부과학회지 Vol.38 No.12
Letterer-Siwe disease is one of Langerhans cell histiocytosis and characterized by proliferation of Langerhans cells. It's clinical features are onset of infancy, hemorrhagic crusted papules and petechiae, hepatomegaly, lymphadenopathy, localized bone defect, and fatal outcome. We report a 38-year-old woman with hepatomegaly, lymphadenopathy, scaly papules and petechiae on the trunk. The eletronmicroscopy showed a tennis racquet shaped Birbeck granules in cytoplasm of histiocyte. Systemic treatment with etoposide, cyclophosphamide, prednisone, and vincristine was effective.