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- 저자 : 오현덕(Hyun-Duk Oh) (검색결과 4 건)
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가미녕신환(加味寧神丸)이 CT105로 유도된 Neuro2A 세포주에서의 항치매 효과(效果)
방재선,윤현덕,신오철,신유정,박치상,Bang, Jae-Sun,Yoon, Hyun-Duk,Shin, Oh-Chul,Shin, Yoo-Jung,Park, Chi-Sang 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.3
The water extract of Gamiyaengshinhwan (GYH), has been used in vitro tests for its beneficial effects on neuronal survival and neuroprotective functions, particularly in connection with CT105-related dementias and Alzheimer's disease(AD). CT105 derived from proteolytic processing of the $\beta$-amyloid precursor protein (APP), including the amyloid-$\beta$ peptide ($A{\beta}$), plays a critical role in the pathogenesis of Alzheimer's dementia. We determined that transfected overexpressing APP695 and $A{\beta}$ CT105 have a profound attenuation in the Increase in CT105 expressing neuro2A cells from GYH. Experimental evidence indicates that GYH protects against neuronal damage from cells, but its cellular and molecular mechanisms remain unknown. Using a neuroblastoma cell line stably expressing CT105-associated neuronal degeneration, we demonstrated that GYH inhibits formation of amyloid-$\beta$ fragment ($A{\beta}$ CT105). which are the characteristic, and possibly causative, features of AD. The decreased CT105 $A{\beta}$ in the presence of GYH was observed in the conditioned medium of this CT105-secreting cell line under in vitro. In the cells, GYH significantly attenuated mitochondrion-initiated apoptosis and decreased the activity of Bax, a key enzyme in the apoptosis cell-signaling cascade. These results suggest that neuronal damage in AD might be due to two factors: a direct CT05 toxicity and the apoptosis initiated by the mitochondria. Multiple cellular and molecular neuroprotective mechanisms, including attenuation of apoptosis and direct inhibition of CT105 aggregation, underlie the neuroprotective effects of GYH.
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황련아교탕(黃連阿膠湯)이 Free Cholesterol에 의한 혈관내피세포 손상에 미치는 영향
이소연,윤현덕,신오철,신유정,박치상,Lee, So-Yeon,Yoon, Hyun-Duk,Shin, Oh-Chul,Shin, Yoo-Jung,Park, Chi-Sang 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.3
Hwangryunagyotang is supposed to have significant effects on some sorts of cardiovascular diseases like atherosclerosis. For this study. ACAT inhibitor was put in LDLR -/- mice to derive free cholesterol from it. This was to examine the effectiveness of Hwangryunnagyotang on its protecting and recovering function with endothelial cells damaged by free cholesterol through experimental. The results reported below. Hwangryunagyotang suppressed the crystallization of reactive oxygen species in macrophages and the numbers of free cholesterol crystal plate structured and reduced fragmentation of nucleus in ECV 304 cell strain by ACAT inhibitor significantly. Hwangryunagyotang also suppressed the necrosis of tissue in LDLR -/- mice' (treated with ACAT inhibitor) inflammatory portion which is adjacent to aortic root, proximal aorta and carotid artery by immunohistochemistry and fluorescence microscopy. On the whole, Hwangryunagyotang suppressed the necrosis of endothelial cells and especially it's effcet for the necrosis of para-myocardial tissues by free cholesterol. With this result, I suggest Hwangryunagyotang might have protective and recovery effects on atherosclerosis, so we need to carry on this study henceforth clinically and experimentally as well.
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복합운송용 LNG탱크컨테이너의 국내도입 활성화 방안 연구
배현옥(Hyun-Ok Bae),이계승(Kye-Seung Lee),백승진(Seung-Jin Back),하오근(Oh-Keun Ha),공현덕(Hyun-Duk Kong) 한국철도학회 2013 한국철도학회 학술발표대회논문집 Vol.2013 No.5
친환경 에너지로 각광받고 있는 LNG는 기타 에너지원에 비해 안전하고 저렴한 특징이 있다.이러한 혜택을 보다 많은 국민들에게 보급ㆍ확산을 해야 하지만 산간지역의 지리적 제약과 경제성 등의 사유로 인프라 구축이 어려우므로 도시지역과 산간 지역 간의 에너지 빈익빈 부익부 현상이 심화되고 있다. 이러한 문제점을 해결하기 위해 육상운송(철도ㆍ도로)과 해상운송에서 복합적으로 사용 가능하고 저장소로도 이용 가능한 LNG탱크컨테이너를 개발하였다. LNG 탱크컨테이너의 원활한 육상운송을 위해 시연사업 계획을 수립하고 운송 단계별 체크리스트를 기반으로 평택 LNG 기지에서 평창 알펜시아 리조트까지 육상운송 시연사업을 시행하였다. 이를 토대로 LNG 탱크컨테이너의 육상운송 가능성과 활성화 방안을 제시하였다. LNG which has been very popular as one of eco-friendly energy sources has a clear characteristics in that it is safe and cheap compared with other energy sources. It should be supplied and spread to many people so that they can enjoy this benefit. However, as it is difficult to establish necessary infrastructures due to geographical constraints in the mountain regions and economic feasibility, the polarization of wealth has been much worser over time. Under these circumstances, the study developed a LNG tank container which could complexly be used for land (railway and road) and maritime transportation and as a storage facility to solve this problem. The study established a demonstration project plan for a smooth land transportation of LNG containers and carried out a demonstration project for a land transportation from Pyeongtaek LNG base to Alpensia Resort in Pyeongchang based on a checklist by transportation stage. The study presented the possibility of transporting LNG tank container transportation by land and a revitalization plan.
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ScienceON
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