B형 간염 전파관련요인에 관한 역학적 연구

오민화,Oh, Min-Hwa 대한예방의학회 1984 Journal of Preventive Medicine and Public Health Vol.17 No.1

An attempt to confirm the associations of some selected risk factors of HBV infection and measure their risks, a cross-sectional study with 1,209 urban office workers was carried out. For the study, a simple questionnaire which contained several questions on personal experience and behaviors on several known selected risk factors of HBV infection was applied to each subject, and the Hepatitis B virus surface antigen and its antibody were checked by RPHA and PHA method, respectively. Risk factors chosen for this study were experience of blood transfusion and personal contact variables, such as frequencies of eating-out, drinking after office hours, going to tea room, sharing cigarettes, etc. The results obtained were as follows: 1. The proportion of HBsAg positive was 10.6%, and total HVB infected including the Anti-HBs positive cases without vaccination was 44.2%. Both were higher in male than in female. 2. Frequent personal contact through glasses and dishes in eating-outs and drinkings turned out not to be a significant risk factor of Hepatitis B surface antigenecity. 3. Frequent visits to tea room was a significant risk factor of HBV infection which combined HBsAg positive cases and Anti-HBs cases who had not received HBV vaccination. The odds ratio was 1.56 4. Blood transfusion was not a significant risk factor of both HBsAg positive and total HBV infection. In summary, indirect oral contacts through eating-outs and drinkings was not significant risk factor in Korea at least between adults. Blood transfusion is no more major source of HBV infection in Korea probably because the adquate screening test of HBsAg for the blood donors is being made.

한국인 성인 남성들에서의 음주와 생화학적 간기능간의 관련성 연구

오민화 가톨릭 대학 산업의학 쎈타 산업의학연구소 1991 韓國의 産業醫學 Vol.30 No.4

To investigate the hepatotoxic effects of alcohol drinking in adult Korean males, relationship between drinking and biochemical liver function tests(LFT)vales were studied on 526 males who visited Inha University Hospital for multiphasic health screening during one year period from January 1, 1990 to December 31, 1990. Major findings obtained from the study are as follows: 1. Four major LFT values(SGOT, SGPT, ALP and r-GTP)were higher in drinkers than non-drinkers, The difference of r-GTP values was statistically significant. 2. The elevation of those LFT values were statistically significant when the subjects were in their 40s and younger. There were no consistent trends in differences of LFTs when the subjects were strarified with their social classes, smoking status, obesity level and HBs antigenicity. In conclusion, this study confirmed the hepatotoxic effects of alcohol drinking in Korean adult males, and found that the ill-health effects of alcohol drinking was further evident in relatively young adults.

유리규산과 석탄분진으로 자극한 흰쥐의 폐포대식세포에서 유리된 염증성 및 섬유화 매개물질의 변동

오민화,윤임중 가톨릭대학 (가톨릭신학대학) 대학원 1994 가톨릭大學醫學部 論文集 Vol.47 No.2

폐포대식세포의 시험관내 자극이 폐섬유화에 미치는 영향

오민화 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.1

Interstitial lung disorders are characterized by chronic inflammation of the lower respiratory tract that include increased numbers of activated alveolar macrophages and fibroblasts. These increased numbers of fibroblasts may be influenced by the alveolar macrophage released factor which was known as alveolar macrophage derived growth factor. To evaluate this hypothesis, alveolar macrophages from bronchoalveolar lavage fluid in rat were incubated with various stimulants including lipopolysaccharide(LPS), free silica dust(SiO₂), natural carbon dust(NC) for 4 hours and we added these supernatants to the culture of fibroblasts. and we evaluated the fibroblast proliferation, ATP and protein in 1, 2, 3 days. The results were as follows; 1. The number of fibroblasts in groups of LPS and SiO₂showed significant increase in comparison with the control group but there was no difference between NC and control groups. 2. The measurements of ATP in groups of LPS and SiO₂tended to be higher than those in the control, and also higher in NC group at the 2nd day than those of control. 3. The amount of protein in LPS and SiO₂increased markedly compared with the control group but there was no difference between NC and control groups. 4. In LPS group, we can observe the decrease of ATP and protein after the peak at the 1st day, but SiO₂group show the continuous increase of ATP and protein during the observation period. 5. Increased proportion of ATP and protein indicated their sensitive changes compared with the fiberglass proliferation. These results suggest alveolar macrophages act as the important integrator of the fibrosis process in interstitial lung disorders.

스타이렌과 산화스타이렌에 의한 자매염색분체 교환유도

이세훈,오민화 가톨릭 대학 산업의학 쎈타 산업의학연구소 1991 韓國의 産業醫學 Vol.30 No.4

This study was designed to investigate the effect of styrene-7,8oxide(styrene oxide) on their potentialto induce of sister chromatid exchanges(SCE) in phytohaemagglutinin-stimulated human whole blood lymphocytes cultured for 72 hours. The treatment with styrene or styrene oxide diluted by acetone were carried out 48 hour before harvest. The concentration of styrene was 1.0,1.5 and 2.0 mM and that styrene oxide was 50 and 100 M, and control group was treated wiht acetone only. A dose-dependent increase of SCE was observed in lymphocytes treated with styrene or with styrene oxide. The toxictiy of styrene oxide was about 15times of that of styrene considering the ability of inducing SCE in the cultured human lymphocytes and cell replicationindex. This study result was on the line that the active metabolite formed from styrene through the action of the erythrocytes is styrene oxide.

암모니아 가스 폭로후에 발생한 폐 섬유화증 1예

임현우,임영,윤임중,오민화 大韓産業醫學會 1991 대한직업환경의학회지 Vol.3 No.2

Ammonia is highly water soluble and causes injury primarily to the mucous membranes and the upper respiratory tract. Patients who survive the initial exposure to ammonia can develop tracheobronchitis, bronchoconstriction, and mucous hypersecretion. Most of the affected persons well recover, but some of them may suffer from the progressive findings such as bronchiectasis, bronchiolitis obliterans and rarely pulmonary fibrosis. We experienced bronchiectasis and bronchiolitis obliterans in a worker (34 yr, male) following ammonia burns on the respiratory tract. This case was exposed to anhydrous ammonia fumes for several minutes by bursting of ammonia pipe-line in the cold storage room of a refrigerator boat. Thereafter, he was admitted by severe dyspnea and ocular damage at a hospital in the vicinity. Intubation and mechanical ventilation were applied to him under the impression of adult respiratory distress syndrome. After 193 days of accident, he was transfered from the hospital to us, and complained of intermittent hemoptysis, recurrent bronchial infectious symptoms, massive pyogenic sputum, hoarseness, and dyspnea. The severe bronchiectatic change was confirmed in both lung field by bronchogram, however, bronchiolitis obliterans was also suspected by bronchoscopy with transbronchial lung biopsy and lung perfusion scan. So we report a case of severe bronchiectatic change and bronchiolitis obliterans after exposure to ammonia gas.

청력측정시 헤드폰 Audiocup부착 여부에 따른 청력수준의 차이

오민화,피영규,이원철,박정일,구정완 카톨릭대학 산업의학 센타 산업의학연구소 1997 韓國의 産業醫學 Vol.36 No.2

This study was conducted to evaluate hearing thresholds according to wearing audiocups. The subjects were composed of white-collar workers of a non-noise- exposed population for general health examination and healthy person for multiphasic health examination in hospital of university. Using self-recording questionnaire method, general characteristics, past or present noisy job, past illness history, past military service, present upper respiratory tract infection and taking ototoxic drug use were obtained. Then they were examined otoscopic test and audiometry of 1,000㎐ and 4,000㎐ in the soundproof booth The collected data excluded factors influencing hearing were analysed to wearing audiocups for 186 subjects on 20-59 years of age and some major results are as follow: 1. Hearing thresholds of group with audiocups were slightly decreased than that of group without audiocups in all years of age for 1000㎐. 2. Hearing thresholds of group with audiocups were significantly decreased than that of group without audiocuos in 20-29, 40-49 years of age for 4000㎐. In 30-39, 50-59years of age, it was not signigicant differences between two groups due to small number of subjects. In conclusion, it suggests that the audiometry wearing audiocups are more accurate because these are the most applicable to excess noise problem in testing areas. There-fore, that will reduce numbers of persons who should take the close examination and prevent the worker from wasting work times and also reduce costs of examination.

양안 근점거리의 분포형

구정완,오민화,이승한 가톨릭대학산업의학센타 산업의학연구소 1991 韓國의 産業醫學 Vol.30 No.2

Near point distance for both eyes of 71 healthy subjects. who no special eye conditions, were measured in order to clarify their distribution form and to select a measure that is suited to continuous observation of visual fatigue of VDT workers. The results were as follows: 1. Near point distance for both eyes(appear. disappear) followed normal distribution only after natural log-transformation(Shapiro-Wilk test). 2. The variance and the coefficient of variation of near point distance(appear) were 0.04 and 4.13, respectively, while they were 0.08 and 6.30 in near point distance(disappear). The findings suggested that near point distance(appear) could be a preferable measure to near point distance(disappear)in the sequential monitoring of visual fatigue. 3. The mean near point distance(appear, disappear)for both eyes of study subjects were 138,82 mm in the age4 group of 20-29 years and were 156,97 mm in the age group of 30-39 years. respectively.

성인 남자의 동맥경화 위험 인자에 관한 분석

한영미,오민화,김삼수 大韓家庭醫學會 1989 Korean Journal of Family Medicine Vol.10 No.5

염증부위에 대한 전자치료의 효과여부

문인숙,오민화 梨花女子大學校 醫科大學 1975 梨花醫學誌 Vol.- No.8