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홍삼 내 ginsenosides의 경구용 제제 개발을 위한 전략수립
연원기,조정원 충남대학교 약학대학 의약품개발연구소 2013 藥學論文集 Vol.28 No.-
Ginsenosides saponins are phytochemically extracted from red ginseng, and have been regarded as the principal components manifesting the pharmacologic activities. Saponins are very soluble in water but poorly absorbed when administrated orally. Moreover, they have some disadvantages including the decomposition in acid medium. Therefore various designs and techniques have been studied for development of optimal formulation and modification of release profile. This review focused on pH-response polymer and bioadhesive polymer considering the low stability in acid medium and the low permeability in mucosal membrane of saponins. The application of these polymers are considered as potential strategy for improvement of bioavailability in oral delivery of saponins.
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Preparation and characterization of mucoadhesive enteric-coating ginsenoside-loaded microparticles
백종섭,연원기,이초아,황성주,박정숙,김동출,조정원 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.5
Ginsenoside saponins are phytochemicallyextracted from red ginseng and have been regarded as theprincipal components manifesting the pharmacologicactivities. Saponins are very soluble in water but poorlyabsorbed when orally administrated. Moreover, they havesome disadvantages including the decomposition in acidmedium. The aim of this study was to develop oral formulationof ginsenosides composed of enteric-coatingpolymer and mucoadhesive polymer considering the lowstability in acid medium and the low permeability of saponins. Ginsenoside-loaded microparticles were prepared byspray dryer. The influences of various parameters such asthe ratio of saponin to polymer, feed concentration, feedrate, inlet/outlet temperature and additional excipientsduring spray-drying were investigated. In vitro releaseprofile of ginsenoside-loaded microparticles using additionalexcipients, ginsenoside saponin Rg1 or Rb1 showedan 18 or 13 % release in pH 1.2 when ethyl cellulose wasadded. Also, ginsenoside-loaded microparticles exhibitedmucoadhesive properties in the presence of chitosan. Theapplication of these polymers is being considered as thepotential strategy for improvement of bioavailability insaponin delivery, orally.
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