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양진원,여희경,윤지혜,이정운 한국독성학회 2019 Toxicological Research Vol.35 No.4
Curcumin, a hydrophobic polyphenol isolated from the Curcuma longa L. plant, has many pharmacological properties, including antioxidant, anti-inflammatory, and chemo-preventive activities. Curcumin has been shown to have potential in preventing nonalcoholic fatty liver disease (NAFLD). However, the low bioavailability of curcumin has proven to be a major limiting factor in its clinical adoption. Theracurmin, a highly bioavailable curcumin that utilizes micronized technology showed improved biological absorbability in vivo. The aim of this study was to investigate the role of theracurmin in modulating hepatic lipid metabolism in vivo. A fatty liver mouse model was produced by feeding mice a high fat diet (HFD; 60% fat) for 12 weeks. We found that treatment for 12 weeks with theracurmin significantly lowered plasma triacylglycerol (TG) levels and reduced HFD-induced liver fat accumulation. Theracurmin treatment lowered hepatic TG and total cholesterol (T-CHO) levels in HFD-fed mice compared to controls. In addition, theracurmin administration significantly reduced lipid peroxidation and cellular damage caused by reactive oxygen species in HFD-fed mice. Overall, these results suggest that theracurmin has the ability to control lipid metabolism and can potentially serve as an effective therapeutic remedy for the prevention of fatty liver.
강남이,오윤신,여희경,백현규,장세은 한국식생활문화학회 2021 韓國食生活文化學會誌 Vol.36 No.6
The fruit stalk of Hovenia dulcis (H.dulcis) is traditionally used to relieve hangovers in Korea. Theracurmin is a highlyabsorbable curcumin preparation which increases the bioavailability of curcumin. Curcumin is known for its antioxidant andanti-inflammatory effects. However, the role of this combination in lowering alcohol levels in the body, thereby alleviatingthe severity of alcohol-induced hangover has not been investigated. Therefore, we conducted a study to investigate theeliminatory effects of a health drink containing the extract of the H. dulcis fruit stalk and theracurmin (theracurmin drink) onethanol-induced hangover in rats. The theracurmin drink delivered orally to rats 30 mins before the administration of 40%ethanol (5 g/kg body weight), lowered the concentration of ethanol and acetaldehyde in the blood samples collected 1, 3,and 5 h after ethanol administration. Furthermore, the theracurmin drink increased the activities of alcohol dehydrogenaseand aldehyde dehydrogenase enzymes. The effectiveness of the theracurmin drink was thus superior to that of other healthdrink products, suggesting that its consumption may alleviate or prevent an alcohol-induced hangover.
임혜은 ( Hye Eun Im ),여희경 ( Hee Kyung Yoe ),장서영 ( Seo Young Chang ),한명주 ( Myung Joo Han ) 한국식생활문화학회 2012 韓國食生活文化學會誌 Vol.27 No.4
The objectives of this study were to investigate the quality characteristics of Gondregaedduck containing 0, 10, 20, and 30% Cirsium setidens. By increasing the level of Cirsium setidens, Hunter color L and a values of Gondregaedduck decreased, whereas b value increased. Hardness, springiness, and cohesiveness of Gondregaedduck decreased upon addition of Cirsium setidens. Over 3 days of storage, Gondregaedduck showed a slightly high total bacterial count compared to control. Sensory evaluation showed that Gondregaedduck containing 10% Cirsium setidens had higher color, taste preference, and overall acceptability.