http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Biomaterials as Antigen Delivery Carrier for Cancer Immunotherapy
엄우람,Anuradha Gupta,송석호,김찬호,박재형 한국고분자학회 2021 Macromolecular Research Vol.29 No.12
Since immunotherapy provides an opportunity to treat metastatic and disseminated tumors, it has become a major treatment strategy for cancer. However, current cancer immunotherapeutics have often exhibited insufficient practical outcomes, primarily attributed to inefficient delivery of tumor-associated antigens to elicit anticancer immunity. To achieve improved therapeutic efficacy, numerous efforts have been made to harness biomaterials for the targeted or sustained delivery of tumor-associated antigens to antigen-presenting cells. In this review, we highlight recent advances in the development of biomaterials to deliver tumor-associated antigens and their therapeutic potential for cancer treatment.
Immunogenic cell death-inducible nanobubbles for cancer immunotherapy
엄우람,고혜원,박재형 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
Recently, immunogenic cell death has emerged as an alternative method for utilizing dying cancer cells to elicit an antitumor immune response through conventional anticancer therapy. However, proteolysis and oxidation of alarmins during the apoptotic process occur irreversible loss of immunogenicity. Here, we report nanobubble-induced immunogenic cell death that can induce the release of intact damage-associated molecular patterns and tumor-associated antigens through physical disruption of the cellular membrane.