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신경특이성 에놀효소 (N.S.E) 의 검사법과 종양 marker로서 의 의
양경모 ( K M Yang ),한미경 ( M K Han ),지세웅 ( S W Ji ),박승진 ( S J Park ) 대한임상검사과학회 1990 대한임상검사과학회지(KJCLS) Vol.22 No.1
Enolase is the glycolytic enzyme widely distributed in mamalian tissue and consists of three distinct subunits alpha, beta and gamma. In the central nervous system they are present as a a, ay and yy forms, they are useful markers for cell classes in the nervous system. Raised serum NSE levels occur in neuroendocrine neoplasms, small cell carcinoma of the lung (SSCL) and neuroblastoma and serum NSE levels are greatly useful for diagnosis and in monitoring patient with SCCL and pediatric-neuroblastoma.
양경모 ( K M Yang ),지세웅 ( S U Ji ),한미경 ( M K Han ),박승진 ( S J Park ) 대한임상검사과학회 1991 대한임상검사과학회지(KJCLS) Vol.23 No.1
TATI is a new tumor marker which has been identified in the urine of all overian cancer patients. This peptide occurs in high concentrations in the urine and serum of patients with malignant tumors. The mean serum level ofT A TI in healthy subjects is 11J.tg/l. The urinary excretion is 7-50J.tg/g creatinine. T A TI is very sensitive marker for pancreatic cancer and mucinous ovarian cancer. TATI and CA-125 show agreement rate as 20%, T A TI and CA 19-9 show 65%.
B형, c형 간염 바이러스 양성자에게서 type III procollagen-NH2 propeptide (p III NP) 검사
이명희 ( M H Lee ),양경모 ( K M Yang ),최정숙 ( J S Choi ) 대한임상검사과학회 1991 대한임상검사과학회지(KJCLS) Vol.23 No.1
Collagen is a major constitutent of most dense and loose connective tissues in the body. So far there are reported for 6types of collagen. Type III collagen is synthesized as a procollagen which contains propeptide extensions at both ends of the molecule. It has been shown that the concentration of antigens related to the aminoterminal propeptide of type III Procollagen (PIIINP) where there is excessive deposition of collagen such as liver fibrosis and cirrhosis or myelofibrosis or malignant disease as well as during normal growth. We meassured serum PIIINP concentration in 80 individuals for two groups- one group ( 40 individuals) confirmed seropositive HBs Ag, HBe Ag, the other 40 samples was positive for HCV Ab test. We used a radioimmunoassay kit [Procollagen (P IIINP) RIA : Farmos Diagnostica, Finland] and reference values for healthy individuals ranged from 1. 7 to 4. 2,ug/ml PIIINP concentrations were mild elevated in 7 samples(4.3-7.6,ug/ml) and high elevated in 5 sample(9.0-13.2,ug/ml) with HBe Ag positive as well as HBs Ag. And in case of HCV Ab positive 40 samples, P IIINP concentration were elevated in 24 sample totally(4.3-21,ug/ml).