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여성의 수치심, 자기용서와 자살생각 -자기용서의 매개효과를 중심으로-
심혜선 ( Hye Sun Shim ),김지현 ( Ji Hyeon Kim ) 충남대학교 교육연구소 2013 교육연구논총 Vol.34 No.1
본 연구는 여성의 수치심과 자살생각 간 관계를 자기용서가 매개하는지 알아보기 위해 수행되었다. 서울, 경기 및 충남 지역의 18세 이상 39세 이하의 여성 369명을 대상으로 설문을 실시하였다. 측정도구로는 한국판 자의식적 정서 척도(TOSCA-3), 한국판 자기용서 척도(SSFS-K), 한국판 자살생각 척도(K-BSI)를 사용하였다. 수집된 자료는 SPSS 17.0을 사용하여 분석했으며, 상관분석, 위계적 회귀분석을 통해 매개효과를 검증 했다. 연구 결과, 여성에게 있어서 수치심과 자살생각이 유의한 관계가 있고, 자기용서는 수치심과 자살생각과의 관계에서 부분매개효과를 보임을 알 수 있었다. 이는 상담 장면에서 자신의 실수나 잘못으로 인해 자기 파괴적 행동, 생각을 하는 여성 내담자들에게 있어 수치심을 잘 다루는 것이 중요하다는 것을 의미한다. 더불어 자기 용서를 할 수 있도록 도움으로써 자살생각 같은 심리적 고통을 완화시킬 수 있을 것이다. The increasing suicide rate is a serious social problem in Korea. The purpose of this research was to examine relationships among shame, self-forgiveness, and suicidal ideation. And based on previous researches, to investigate whether self-forgiveness mediates the relationship between shame and suicidal ideation. For this research 374 women 18-39 years old living in Seoul, Gyeonggi, and Chungnam, and finally 369 copies of questionnaires are used for statistical analysis. We used such instruments as TOSCA-3(Test of Self - Conscious Affect), SSFS-K(The Korean version of the State Self-Forgiveness Scale) and K-BSI(The Korean Version of the Beck Scale for Suicide Ideation). All data collected were analyzed with correlation analysis and hierarchical regression analysis by using SPSS 17.0, and the mediating effect was verified through multiple regression analysis. In summary, this study achieved the following. First, correlation analysis was performed to find out the relationship between shame, self-forgiveness and suicidal ideation in women. As a result, shame showed the negative correlation with self-forgiveness, and shame showed the positive correlation with suicidal ideation. Second, regression analysis was performed. Self-forgiveness demonstrated partial mediating effect on the relationship between shame and suicidal ideation.
고양이 위 평활근에서 KCI에 의한 근수축에 대한 Protein Kinase의 조절
김명석,이덕주,심혜선,김승록,조양혁,윤신희,한상준,심상수 대한소화기학회 1998 대한소화기학회지 Vol.32 No.3
Background/Aims: Smooth muscle contraction and relaxation are suggested to be modulated by intracellular Ca^(2+), protein kinases and tyrosine kinases. To investigate whether protein kinases are invelved in the gastric smooth muscle contraction induced by KCl, the effects of protein kinase inhibitors and tyrosine kinase inhibitors on the contractions were observed in cat gastric muscle. Methods: Circular muscle strips were obtained from the fundus of stomach. The isometric contraction of the muscle strips were measured in isolated organ baths using force transducers and polygraph. Results: KCl caused a dose-dependent contraction of cat gastric smooth muscle, which was dependent on the extracellular Ca^(2+) concentration and the Ca^(2+) influx through voltage-dependent Ca^(2+) channel. Both protein kinase C and tyrosine kinase inhibitors significantly inhibited the KCl-induced contraction. The combined inhibitory effect of two protein kinase inhibitors was greater than that of each one. The combined effects of protein kinase inhibitors together with verapamil were greater than that of each one. Calmodulin antagonists have no inhibitory effect on KCl-induced contraction. Conclusions: Protein kinase C and tyrosine kinase are suggested to be involved in the contraction induced by KCl and these protein kinases play a role in the modulation of voltage-dependent Ca^(2+) channel activity and Ca^(2+) sensitivity of contractile protein of the cat gastric smooth muscle.
고양이 위 평활근 수축에 대한 Vanadate 와 Pervanadate 의 효과
김명석,이덕주,심혜선,조양혁,심상수,최효봉,윤신희,한상준 대한소화기학회 1999 대한소화기학회지 Vol.33 No.1
Background/Aims: Activated mammalian cells produce the reactive oxygen species from oxygen and they convert vanadate into pervanadate. The aim of the present study was to compare the contactile mechanisms of vanadate and pervanadate in the gastric smooth muscle of cat. Methods: Muscle strips were isolated from the fundus of cat stomach to measure isometric contraction. Muscle cells were prepared to measure the activity of protein kinase C (PKC) and the level of protein tyrosine phosphorylation. Results: Both vanadate and pervanadate caused contractions of smooth muscle and the contraction induced by pervanadate was greater than that induced by vanadate. These contractions depended on the extracellular Ca2+ and the influx of extracellular Ca2+ occurred through voltage-dependent Ca2+ channel. Protein kinase antagonist inhibited the vanadate-induced contraction. However, the inhibitory effect of H-7 was smaller in pervanadate-induced contraction. Both vanadate and pervanadate had no effect on the activity of phospholipase C, but pervanadate significantly increased protein tyrosine phosphorylation. Conclusions: The contraction induced by vanadate or pervanadate may depend on the influx of extracellular Ca2+ via voltage-dependent Ca2+ channel Vanadate seems to be more dependent on protein kinase C. The difference of contraction mechanism by these elements may be related to the differences in the level of protein tyrosine phosphorylation (Kor J Gastroenterol 1999;33:1 - 10)