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人蔘의 解毒作用(特히 Alcohol 中毒에 對한 人蔘의 治療效果)에 關한 硏究
申萬鍊 고려대학교 의과대학 1976 고려대 의대 잡지 Vol.13 No.2
In order to investigate the influences of panax ginseng (white ginseng and red ginseng) on the experimental studies had been carried out anesthetic effect and toxic effect of alcohol, following with albino rabbits, mongorian dogs and mice. The anesthetic effect of alcohol was observed by measuring the induction time, anesthetic time, recovery time and duration from the beginning of induction to the recovery of anesthesia (total time), respectively, and toxic effect (LD_(50)) of alcohol were measured. In addition to these experiments, alcohol concentration in blood, blood sugar level, serum transaminase (GOT and GFT) activities and serum alkaline phosphatase activity were measured. Also in order to study the clinical effects of alcohol in healthy students, code substitution, response time and muscle coordination were tested. The results were obtained as follows; 1. In the rabbits and mongorian dogs, the induction time of anesthesia by administration of alcohol was delayed by the pretreatment of ginseng but recovery time and total time of anesthesia were markedly shortened. 2. The blood alcohol concentration was decreased by the pretreatment of ginseng but not affected in mongorian dogs. 3. The blood sugar level, serum transaminase (GOT and GPT) activities and alkaline phosphatase activity in rabbits and dogs induced by administration of alcohol mere affected by the pretreatment of ginseng. Because those were included within normal ranges, the author was supposed 10 have no remarkable means. 4. Liver alcohol dehydrogenase activity of rabbit was increased by the pretreatment of ginseig, especially it was markedly increased by the pretreatment of red ginseng. 5. The average lethal dose of alcohol to mice was increased by the pretreatment of ginseng, especially it was markedly increased by the pretreatment of red ginseng. 6. In the clinical experments, the blood alcohol concentration induced by alcohol administration was not affected by the pretreatment of ginseng whereas the blood sugar level was increased. But these levels were within normal range. Blood alcohol concentration and blood sugar level were measured after 3 hours alcohol administration. 7. The response time of healthy students administered alcohol was markedly shortened by the pretreatment of ginseng but the experiments on the code substitution and muscle coordination were not affected.
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Reserpine 毒性에 미치는 Iproniazid 및 Pyrogallol의 影響
申萬鍊 고려대학교 의과대학 1976 고려대 의대 잡지 Vol.13 No.2
Reserpine is widely used in mental disease and hypertension. It evokes a tranquilizing action on the cerebrum which appears to be produced by smaller doses than that required for hypertension. We usually experience some side effects and toxic actions of reserpine in clinical use, and so the author attempted to find out the antidotal agent for reserpine toxicity. It is well known that reserpine releases catecholamines from the sympathetic innervated organs in small doses, and depletes them in large doses. The catecholamines are usually metabolized by monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT). It is postulated that iproniazid is a MA0 inhibitor, and pyrogallol is a COMT inhibitor. The author, therefore, attempted to investigate the influences of iproniazid and pyroaallol on the toxic effects of reserpine on mice and also the effects of reserpine on the blood sugar concentration, serum total cholesterol, and serum transaminase (GOT, GPT) activities of rabbits pretreated with iproniazid or pyrogallol. Two groups of rabbits were pretreated; via intraperitoneal injection, one group received a single dose of ipsoniazid 20㎎/㎏, and the other group received a single dose of pyrogallol 30㎎/㎏. Both groups were then administered reserpine 0.5 ㎎/㎏ intraperitoneally. The results obtained are summarized as follows: 1. The LD_(50) of reserpine on mice pretreated with iproniazid or pyrogallol was increased, especially in the mice pretreated with iproniazid. 2. The blood sugar concentration of normal rabbits was decreased by iproniazid or pyrogallol injection, but the blood sugar concentration changed slightly by reserpine alone, was inclined to be decreased by pretreatment of iproniazid or pyrogallol, and especially, the blood sugar concentration was increased 6 hours after the pretreatment of pyrogallol, but after 48 hours, it was decreased. 3. The serum total cholesterol concentration of normal rabbits was not influenced by iproniazid or pvrogallol injection, but the serum total cholesterol concentration increased by reserpine alone was markedly decreased 6 hours after the pretreatment of iproniazid or pyrogallol, but after 48 hours, it was increased. 4. The serum GOT activities of normal rabbits were inclined to be decreased by iproniazid or pyrogallol injestion, but the serum GOT activities decreased by reserpine alone were increased by pretreatment of iproniazid or pyrogallol. 5. The serum GPT activities of normal rabbits were not influenced by iproniazid or pyrogallol injection, and also the serum GPT activities changed slightly by reserpine alone were not influenced by pretreatment of ipronazid d or pyrogallol.
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各種波長可視光線照射時의 正常白鼠의 好酸球數의 變動및 Chlorpromazine投與時의 影響
申萬鍊,丁東均 최신의학사 1959 最新醫學 Vol.2 No.5
In the previous article, the authors described the fluctuations of 17-ketosteroid values in the rib bit urine after irradiation with various visible r ays, and the administration of chlorpromazine gives no change in the excretes of the substance. In this experiment, the author has observed the changing rate of eosinophiles by the irradiation of isolated rays and also the effects of chlorpromazine on the eosinophile count. The reults are summerized as follows. 1. The irradiation of various visible rays caused a defenite decrease in the eosinophile count inthe rats. The blue ray, the shortest wavelength, has the strongest action of decreasing. while has the rad ray, the longest, the Ieast effect. This suggests that the flashing of visible rays causes a dcfenite stress as would result in the decrease of eosinophile count. 2. There showed no significant difference in the decrease of eosinophile count between the normal rats treated with chlorpromazine and the control rats flashed with normal ray. Therefore, this could demonstrate that chlorpromazine can block the stress action caused by the light.
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申萬鍊 大韓法醫學會 1979 대한법의학회지 Vol.3 No.1
Alcohols are usually used as fuel, astringents, antiseptics and disinfectants. Ethyl alcohol(ethanol) alone can be used as wine. The pharmacological action of ethanol is depression of the reticular activating system of the brain and the associated center. If a man takes ethanol, he feels flushing of faces and some excitement by the depression of the inhibitory control mechanism of brain. With increases of doses of ethanol, all functions of the central nervous system are gradually paralyzed. It is well known that ethanol is metabolized by alcohol dehydrogenase in the liver to acetaldehyde, which is also metabolized to acetic acid by xanthine oxidase. The toxic effects of ethanol in large doses depend on the increase of acetaldehyde concentration in the blood. Disulfiram, an inhibitor of xanthine oxidase, can exaggerate the increase of the blood acetaldehyde concentration after alcohol drinking.
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各種波長可視光線照射時의 家兎尿中 17-Ketosteroid排泄量의 變動 및 Chlorpromazine投與時의 影響
申萬鍊,金在完,張禮世 최신의학사 1959 最新醫學 Vol.2 No.4
The wide use of glamercus illumination in architecture and the overexpeure oi the human bode to the lighting has fecuscd aitcrition on ex? rim ental works to find some biological changes which rn.g -t occur by various visible rays. Since Messer first described in i943 that the functional changes of the autonomic nervous system are caused by certain visible rays, many works have accumlated to indicate that animals flashed with a red visiblc ray develop parasym pathicotony, while do the flashing with a blue ray sympathicotony. Based on these facts, this experiment was attempted to find out bodily functional changes to be caused by various visible rays through the quantitative measurement of 17-ketosteroid in urine. 17-ketosteroid is one of metabolites of corticoid excreted in urine and if the light act as a kind of extrinsic stresses, it might cause easily oversecretion of ACTH in the pituitary glands by which stimulates the adrenal cortex. In experiment, the various visible rays as classified with blue, green, yellow,and red were flashed to rabbits. The rabbits were devided into 3 groups; the 1st was the group irradiated with various rays. the 2nd was the group irradiated after administration of chlorpromazine and t,o-d vhiis the contrr: flashed with the natural compound ray. The results can be summarized as :c flows' 1. The urinary excretion of 17-Ketosteroid rabbits increased to a significant degree by the irradiation with various visible rays as compared with rabbits under the natural compound ray 2. The values of 17-Ketosteroid In urine varied ac-cording to the wave-length of the light, this seems to indicate that there exist some difference in the intensity of light stresses caused by each isolated single ray. 3. The irradiation of various visible rays has given no change in the value of 17-ketosteroids in Urine of the rabbit, previously injected with chlorpromazine. This indicates that the light stress can be blocked by administration of chlorpromazine.
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