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RISS 인기검색어
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- 저자 : 신기철 ( Ki Chyul Shin ) (검색결과 2 건)
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강성욱 ( Seong Wook Kang ),신기철 ( Ki Chyul Shin ),이윤종 ( Yun Jong Lee ),이은봉 ( Eun Bong Lee ),백한주 ( Han Joo Baek ),김현아 ( Hyun Ah Kim ),송영욱 ( Yeong Wook Song ) 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.3
Objective: The predominant histopathologic lesion in Behcet`s disease is vasculitis. Thrombotic complications have been reported in approximately 10~40% of patients with Behcet`s disease, but the precise mechanisms are not known. To investigate the coagualtion abnormalities in patients with Behcet`s disease, coagulation and fibrinolytic activities were examined. Methods: Thirty-two patients with Behcet`s disease and thirty-two healthy individuals as a control group were included in the study. The presence of thrombosis and risk factors for hypercoagulability, and blood components concerning coagulation and fibrinolytic activites were evaluated. Results: Of thirty-two patients with Behcet`s disease, thrombosis was found in four patients(13%). No patient had risk factors for hypercoagulability except one with lymphoma. Levels of white blood cell count(mean±SD 8,362±2,893 vs 5,934±1,755/mm3, p<0.001), erythrocyte sedimentation rate(40.5±37.6 vs 3.3±2.73 mm/hr, p<0.001), C reactive protein(2.26±3.99 vs 1.20±0.26mg/dl, p=0.008), fibrinogen(387.7±128.5 vs 240.6±49.5mg/dl, p<0.001) and von Willebrand factor antigen(131.9±46.6 vs 105.2±1.75%, p=0.008) were significantly higher in patients with Behcet`s disease compared with controls. The level of fibrinogen correlated with erythrocyte sedimentation rate(r=0.721, p<0.001) and C reactive protein (r=0.454, p=0.018). High density lipoprotein(HDL) cholesterol(46.6±12.7 vs 65.5±16.1mg/dl, p<0.001), apolipoprotein A-1(118.8±24.7 vs 134.6±18.5mg/dl, p=0.018) and antithrombin III (92.8±16.7 vs 106.3±14.7%, p=0.004) were significantly lower in patients with Behcet`s disease. No differences were observed in lipoprotein(a), plasminogen, protein C, and protein S activities. Activated protein C(APC) resistance was not observed in any patients with Behcet`s disease. Lupus anticoagulant was positive in four patients(13%). one of whom had deep vein thrombosis. Antiphospholipid antibody was found in one patient(3%), but thrombosis was not found. Conclusions: Significantly higher level of von Willebrand factor antigen was observed in Behcet`s disease, which suggested injury of vascular endothelium. Levels of HDL cholesterol, apolipoprotein A-1 and antithrombin III were decreased in Behcet`s disease. APC resistance was not found.
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전신성~홍반성 루푸스 환자에서 발견된 Klinefelter 증후군 1 예
이은봉,이윤종,김현아,송영욱,최영주,신기철 대한내과학회 2000 대한내과학회지 Vol.59 No.3
The incidence of systemic lupus erythematosus (SLE) is known to be affected by sex hormone. Patients with Klinefelter's syndrome were reported to have abnormal sex hormonal metabolism and their chronic estrogenic stimulation seems to affect the pathogenesis of SLE. Therefore, association of SLE and Klinefelter's syndrome has been considered as a clue of the effect of sex hormone on SLE. We report the first case of Klinefelter's syndrome in a patient with SLE in Korea and discuss the association of SLE with Klinefelter's syndrome.(Korean J Med 59:331-334, 2000)
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