태아 피부에서 Glutathione S-transferase 태반형 (GST-pi)의 면역조직화학적 발현양상

손호찬 ( Ho Chan Son ),이나영 ( See Ryong Park ),박시룡 ( Mi Kyung Kim ),김미경 ( Kye Yong Song ),송계용 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.2

Background: Glutathione S-transferases(GST) are a family of multi-functional enzymes involved in cellular detoxification and excretion of a variety of exogenous and endogenous toxic or carcinogenic compounds. The GST family has been divided into three cla

결체조직형성 흑색종 1 예

손호찬(Ho Chan Son),임연순(Yeon Soon Lim),한지윤(Jee Yoon Han),송계용(Kye Yong Song) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.9

Desmaplastic melanoma is a rare variant of the spindle cell 1anoma that first was recognized and described in 1971 as an invasive fibrosarcoma-like tumor exhi5its an abundant collagenous stroma, These tumors usually arise in sun-damaged skin of the head and neck in older persons, in association with lentigo maligna or de novo. The clinical presentation is often not characteristic, and they may clinically simulate other tumors of the skin. Hence they are often diagnosed late. Histologically, desmoplastic melanoma appears as a nodule of fibrous tissue containing hyperchromatic pleomorphic spindle cells that either are scattered singly, lie in fascicles, or aggregate in nests, and collagenous tissue replacing the reticular dermis, Immunohistochemistry is usuatlly quite helpful as the tumors are almost always immunoreactive with S-100 protein and negative for HMB-45. We report a of desmoplastic melanoma in a 67-year old male who had a walnut sized tumor upon large indurated plaque on the left thigh, A biopsy specimen of the tumor showed that fascicles of spindle cells are interspersed throughout collagenous tissue and most tumor cells are immunoreactive with S-IOO protein. To our knowledge, this is the first case report in Korea. (Korean J Dermatol 2002;40(9): 1100~1104)

노년층의 피부 건강 및 피부 질환의 인식에 대한 분석

김민중 ( Min Joong Kim ),손호찬 ( Ho Chan Son ),유박린 ( Bark Lynn Lew ),심우영 ( Woo Young Sim ),이준영 ( Jun Young Lee ),안규중 ( Kyu Joong Ahn ),송해준 ( Hae Jun Song ),김규한 ( Kyu Han Kim ),조광현 ( Kwang Hyun Cho ),이은소 ( 대한피부과학회 2011 대한피부과학회지 Vol.49 No.2

Background: With the development of medical science and technology, the proportion of the aged in the population has significantly increased. For the same reasons, concerns regarding skin aging and skin diseases in the geriatric population has increased. Objective: To evaluate the recognition of skin health and disease in the elderly. Methods: On April 2009, 190 elderly persons were asked to complete a questionnaire in 5 senior welfare centers in the city of in Korea. The questions included: satisfaction with the subject`s own skin; treatment-seeking behavior; knowledge and common sense about representative skin problems; efforts taken to achieve healthy skin. Results: Among the elderly, 44.74% were dissatisfied with their own skin. The most complained about skin diseases in the elderly were pruritus and xerosis. Also, interest in esthetic problems such as wrinkles and pigmentation was high. On the question of whether they visit a dermatologic clinic when they develop skin problems, 40.53% of subjects said that they visited the dermatologic clinic. However, this means that 59.47% did not visit a dermatologic clinic. A somewhat unexpected finding was that knowledge of skin diseases and esthetic problems were plentiful in the geriatric population. Among the elderly, 81.05% did something to achieve skin health such as using a moisturizer or sunscreen. Conclusion: The present study contributes to our understanding of the recognition of dermatologic problems in the geriatric populations. Dermatologists and society should pay more attention to the provision of correct information and appropriate treatments for skin diseases in the elderly. (Korean J Dermatol 2011; 49(2):141~146)

Phosphatidylcholine Formula를 이용한 지방종의 치료 경험

김지혜 ( Ji Hye Kim ),김준범 ( June Bum Kim ),박향준 ( Hyang Joon Park ),이재승 ( Jae Seung Lee ),조옥자 ( Ok Ja Joh ),김학주 ( Hak Ju Kim ),손호찬 ( Ho Chan Son ),송계용 ( Kye Yong Song ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.8

Background: Lipomas are benign neoplasms composed of mature fat cells. Current treatments are invasive and carry the risk of scarring. For this reason, phosphatidylcholine (PPC) formula has been widely used to treat areas of localized fat accumulation. However, there are few reports on injection lipolysis with injection of PPC formula. Objective: The purpose of this study was to investigate whether injection lipolysis with PPC formula is an effective therapeutic option for patients with lipoma. Methods: Twenty-two lipomas in 7 patients were included. Three sessions at intervals of 6 to 8 weeks were done. Sonographic measurements of lipoma size were repeated before each session. Any side-effects and the patients` satisfaction were noted. In one lipoma, histological changes after lipolysis were described. Results: After three sessions, a significant reduction in lipoma size of 47.4% was achieved. Histology showed a fibrosis with loss of adipocytes. Inflammation occurred in one case, so the patient was excluded from this study. Transient burning sensation and swelling at the injection site were the most common adverse effects. No severe side-effects or systemic reactions were observed. Conclusion: Treatment of lipoma with PPC formula has the potential to be a patient-friendly and well-tolerated therapy that can achieve cosmetically pleasing treatment outcomes. (Korean J Dermatol 2010;48(8):672~677)

단순 한선 극세포종 1예

손호찬,이병진,임연순,한지윤 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.1

Hidroacanthoma simplex is a rare skin tumor which most often develops on the lower extremity of an elderly person. Clinically, the lesion appears as a well-demarcated brownish flat or verrucous plaque, resembling seborrheic keratosis or Bowen's disease. Histologically, it is characterized by intraepidermal nests of basaloid cells within an acanthotic epidermis. there is some controversy over the histogenesis of hidroacanthoma simplex, many consider it an epidermal tumor differentiation into intraepidermal eccrine duct cells. We report a case of hidroacanthoma simplex presented a small verrucous papule on the left foot with the results of an immunohistochemical study. (Korean J Dermatol 2003;41(1) 117∼120)

Trichophyton meontagrophytes에 의한 안면부 잠행 백선 1 예

한지윤,임연순,손호찬,강현영,조윤화 대한피부과학회 2000 대한피부과학회지 Vol.38 No.8

Recently, we have encountered an increasing number of patients who have obtained topical steroids to self-treat various dermatosis. Tinea incognito has been used to describe a dermatophyte infection modified by corticosteroid treatment. Lesions are often atypical appearing and the diagnosis can be delayed or missed. We report a case of tinea incognito with ill-defined erythematous patch and nodules on the right upper eyelid and taken intermittently application with corticosteroid ointment over a period of 1 year. Mycologic studies including KOH mount and fungus culture were positive for hyphae and colonies of Trichophyton mentagrophytes. The lesion was treated with of itraconazole and cured 3 weeks later.

케라틴 항체에 음성소견을 보인 유전분성 태선 2예

송계용,한지윤,조윤화,서동혜,손호찬 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.1

Localized primary cutaneous amyloidosis consists of three types: nodular, macular, and lichenoid amyloidosis. Lichen amyloidosis is characterized by the appearance of paroxysmally itchy lichenoid papules on the shins. Although the origin of the amyloid is controversial and can not provide any definite answer, some of amyloid substances can be derived from epidermal cells and others from degenerative collagen fibers. We suggested the origin of amyloid in our cases as epidermal keratinocyte and collagen degenerations. Because degeneration of basal keratinocyte is observed on electron microscopy and degeneration of collagen is in H&E and Masson's trichrome stain although amyloid materials are negatively stained against pankeratin antibody and collagen antibody. The skin lesion was improved after triamcinolone intralesional injections which reduce collagen synthesis. We report two cases of lichen amyloidosis which stained negatively for antikeratin antibodies and improved with triamcinolone intralesional injection.

Calcipotriol( Daivonex )에 의한 알레르기성 접촉피부염 1예

정민자,한지윤,조윤화,서동혜,손호찬 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.6

The vitamin D3 analogue calcipotriol ointment(Daivonexⓡ) has now been used successfully in the treatment of psoriasis for several years. It is usually well tolerated and safe. The adverse effects are mainly lesional and perilesional irritations, facial irritations, hypercalcemia, etc. The nature of calcipotriol-induced dermatitis is usually considered to be of irritant nature but allergic contact reactions have also been reported. We report a case of allergic contact dermatitis from calcipotriol (Daivonexⓡ).