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기도 상피세포에서 Formoterol과 Budesonide 병합투여가 전사활성과 Interleukin-8 분비에 미치는 효과
김동민 ( Dong Min Kim ),서평주 ( Pyung Joo Seo ),강명수 ( Myung Soo Kang ),지영구 ( Young Koo Jee ) 대한천식알레르기학회 2006 천식 및 알레르기 Vol.26 No.1
Background: Recent clinical studies have shown that the combination of inhaled long acting β2 agonist with inhaled glucocorticoid results in better asthma control than higher doses of glucocorticoids alone. Objective: The present study was designed to investigate whether the long acting β2 agonist (formoterol) or glucocorticoid (budesonide) modulates the transcriptional activity and release of interleukin (IL)-8, and the combination of these two drugs influence transcriptional activity and release of IL-8. Method: The effect of formoterol alone and in combination with budesonide, upon tumor necrosis factor-alpha (TNF-α) stimulated human bronchial epithelial cells were investigated. Transcriptional activity was assessed by luciferase assay, and IL-8 was measured by ELISA. Result: Transcriptional activity and release of IL-8 induced by TNF-α were markedly decreased by budesonide alone, and was weakly affected by formoterol alone. The combination of budesonide with formoterol showed a significant additional suppressive effect on transcriptional activity and release of IL-8 induced by TNF-α. The combination effect of lower doses budesonide with formoterol was superior to higher doses of budesonide alone on the suppression of TNF-α-induced IL-8. Conclusion: The combination of budesonide with formoterol significantly inhibits TNF-α-induced IL-8 secretion compared to higher doses of budesonide alone. The combination of glucocorticoids with β2 agonists is an effective therapeutic strategy in asthma management. (Korean J Asthma Allergy Clin Immunol 2006;26:64-69)