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        • KCI등재

          천궁(川芎)의 뇌조직출혈 흰쥐 힝염증반응에 대한 연구

          백동하 ( Dong Ha Baek ),김도훈 ( Do Hoon Kim ),김연섭 ( Youn Sub Kim ) 대한본초학회 2014 大韓本草學會誌 Vol.29 No.2

          Objectives : Inflammation is mediated by cellular components, such as leukocytes and microglia, and molecular components, including cytokines, extracellular proteases, and reactive oxygen species. Cnidium Rhizoma effects the anti-inflammatory, antioxidant, suppression of the microglia activation and protection of the nerve cell injury. For this reason, we investigated the anti-inflammatory effects of water extracts of Cnidium Rhizoma on intracerebral hemorrhage (ICH). Method : ICH was induced by the stereotaxic intracerebral injection of bacterial collagenase type IV (0.23 U/㎕, 0.1 ㎕/min) in Sprague-Dawley rats. We orally administrated once 3 hours after ICH, then 2 times at 24 hour intervals the water extracts of Cnidium Rhizoma (500 ㎎/㎏), myeloperoxidase (MPO) was observed by using immunofluorescense and expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α) and microglia were observed by using immunohistochemistry. Results : Infiltration of MPO expressing neutrophil, expression of iNOS and TNF-α and activated microglia were significantly reduced in peri-hematoma of the rats fed with water extracts of Cnidium Rhizoma. Conclusion : These results demonstrated that water extracts of Cnidium Rhizoma suppressed an inflammatory reaction through inhibition of MPO, iNOS and TNF-α positive cell and activated microglia number in peri-hematoma of ICH-induced rats.

        • SCOPUSKCI등재

          Design, Syntheses, and Conformational Study of Angiogenesis Inhibitors

          박경수,백동하,임동열,박상돈,김민영,박영선,김양미,Park, Gyeong Su,Baek, Dong Ha,Im, Dong Yeol,Park, Sang Don,Kim, Min Yeong,Park, Yeong Seon,Kim, Yang Mi Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.9

          Since anti-angiogenesis could lead to the suppression of tumor growth, angiogenesis inhibitors have received particular attention for their therapeutic potential. In this study, two angiogenic inhibitors using the bioactive sequence from the kring le 5, AK1(KLYDY), AK2(KLWDF) were designed and synthesized. We have investigated their solution structures using NMR spectroscopy and their activities as angiogenesis inhibitors. AK2 has an intramolecular hydrogen bon d between the side chain amino proton of Lys1 and the carboxyl oxygen of Asp4 with a N ${\cdot}{\cdot}{\cdot}$O distance of $3.27\AA$, while AK1 shows more flexible structures than AK2. Indole ring in Trp is much bigger than the phenyl ring in Tyr and may have good face-to-edge interaction enforcing more rigid and constrained conformational features of AK2. Because of this relatively stable structure, Trp3 in AK2 may have better hydrophobic interaction with Phe5 than Tyr3 in AK1 if two adjacent aromatic groups are located in hydrophobic pocket of receptor. Since AK2 shows the similar anti-angiogenic activities to AK1, we are also able to confirm that the activity of AK1 is irrelevant to the Tyr phosphorylation. More rigid drug with higher activities can be provided by the mimetic approaches. For the further development of the angiogenesis inhibitors, these conformational studies on our lead peptides will be helpful in design of peptidomimetics.

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