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박필성(Pill Sung Park),주용진(Yoing Jin Joo),최영자(Young Ja Choi),성호석(Ho Suk Sung) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.6
We report a case of histiocytic cytophagic panniculitis in a 5-year-old male. The patient has complained of multiple erythematous indurated palques with tenderness on the lower abdomen, periocular areas, left forearm and both thighs associated with high fever for 45 days. Hepatosplenomegaly and enlarged lymph nodes were found. Laboratory data revealed pancytopenia, elevation of liver enzymes and prolon gation of PT and PTT. Histopathologic findings of subcutaneous plaque taken from the left forenrm showed lobular panniculitis with fat necrosis and some phagocytic histiocytes containing erythrocytes, leukocytes, lymphocytes and nuclear debris, that had the appearance of bean bag. There found no atypical histiocytic infiltrations or cellular pleomorphism.
Etretinate 와 Methotrexate로 치유된 소아형 범발성 농포성 건선
백종현(Jong Hyun Paik),박필성(Pill Sung Park),최영자(Young Ja Choi),성호석(Ho Suk Sung) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.1
A case of generalized pustular psoriasis in a 12 year-old girl is described. She had generalized pustular eruptions on erythematous base, presenting lake of pus, yellowish brown crusts and denudation associated with high fever and chills. With the administration of oral etretinate at a dose of 0.8mg/kg/day for 1 week, rapid and dramatic remission was achieved. About 3 months after her discharge, there developed another wave of new pustules with fever. She was again placed on etretinate therapy. However, there was no expected response as before with developing new pustules continuously. At that time, we tried combination therapy with etretinate and methotrexate. the pustules and erythema began to remit, with eventual clearing of the skin in 6 weeks.
왕정길 ( Jeong Kil Wang ),이학중 ( Hak Joong Lee ),왕한영 ( Han Young Wang ),윤혜경 ( Hye Kyoung Yoon ),박필성 ( Pill Sung Park ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.1
Acquired tufted angioma is a benign, slowly progressive angioma with a typical histological pattern that was first described by Wilson-Jones in 1976. We report a case of acquired tufted angioma in a 19 year old female who had erythematous papules and plaques on the right thigh. Histopathological findings showed multiple capillary lobules in a cannonball arrangement scattered throughout dermis, which was diagnostic of acquired tufted angioma. (Korean J Dermatol 1998;36(1): 164-167)
成好錫,崔英子,朴必城 인제대학교 1988 仁濟醫學 Vol.9 No.3
乾癬은 慢性 再發性 皮膚疾患으로 確實한 原因과 發病機轉은 아직도 不明이나, 遺博的 素因에 各種 外的 因子와 免疫學的 因子가 複合 作用하여 發症한다고 생각되고 있다. 著者들은 1983年 1月부터 1987年 12月까지 皮膚科 外來에 來院한 428名의 乾癬患者를 對象으로 臨床的 觀察을 하여 그 成績을 分析 檢討하였다. This clinical study was done to evaluate a general tendency of 428 psoriatics seen during the period from January 1983 to December 1987 at the Department of Dermatology, School of Medicine, Inje University, Pusan Paik Hospital. The results obtained were summarized as follows : 1) The incidence of psoriatics among the all new dermatologic patients during the 5 calendal years(1983-1987) was 2.39%. 2) There were 199 males(46.5%) and 229 females(53.5%) in this series with no significant sexual difference. 3) Age incidence ranged from 1 year(male) to 73 years(female) with peak incidence rate in the age group between 30-39 years(13.8%) in male and 20-29 years(16.1%) in female. 4) The peak age group at the time of onset was between 20-29 years(32.7%) in both sexes. 5) Durations of disease in 144 psoriatics(33.6%) were under 1 year and in 86 psoriatics(20.1%) over 10 years. 6) Psoriais was most prevalent in the spring(30.1%) in this series but there was no significant seasonal variation. 7) Mild itching as a subjective symptom of psoriatic lesions were noted in 43.2% an4 arthralgia in 2.8%. 8) The most frequent sites of involvement were knees(20.7%), elbows(20.0%), scalp(17.6%), entire body(12.7%) and upper & lower extremities were in 10.2% & 9.7% respectively. 7) Familial histories of psoriatics were elicited in 47 patients(10.9%). 10) Clinically 357 of 428 psoriatics(83.4%) were psoriasis vulgaris and pustular psoriasis of palms & soles in 13.3%, guttate psoriasis in 2.3%, generalized pustular psoriasis in 0.7% and psoriatic erythroderma in 0.2%.
Helicobacter pylori 편모 유전자의 클로닝 및 염기서열 분석
이광호,이우곤,조명제,도영미,백승철,강경희,박필성,이상룡 경상대학교 유전공학연구소 1993 遺傳工學硏究所報 Vol.12 No.-
A λgt11 expression libary of H. pylori DNA in E. coli Y1090 was screened with flagellin-specific rabbit antiserum for molecular cloning of the flagellin gene of H. pylori. A positive clone, λHPF4, was obtained and the recombinant antigen expressed from λHPF4 was a fusion protein with the molecular weight of 168kd. Sequence analysis of antigen-encoding DNA showed that an open reading frame composed of 1,536 nucleotides encodes a polypepride with a oredicted molecular size of 54kd. This open reading frame did not show the homology with flaA gene encoding 56kd protein of H. pylori and was confirmed as a unique sequence through homoligy searching. Therefore, the cloned antigen is supposed to be the carboxy-terminal region of the other flagellin protein of H. pylori, flaB, with the molecular weight of 58kd.