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인슐린 비의존형 당뇨병환자에서 중식성 망막증 발생에 관한 종적연구
조구영(Goo Yeong Cho),김상욱(Sang Wook Kim),이미화(Mee Wha Lee),박중열(Joong Yeol Park),제수정(Soo Jung Je),이기업(Ki Up Lee),김기수(Ghi Su Kim) 대한내과학회 1994 대한내과학회지 Vol.47 No.4
N/A Background: Proliferative diabetic retinopathy (PDR), a late stage of diabetic retinopathy, is the com- monest cause of acquired blindness in adults. Despite many previous studies, the risk factors for the development of PDR in Korean NIDDM patients have not been precisely defined yet. The aims of the present study were to evaluate the incidence and the risk factors of PDR. Method: From April to June 1993, we retrospectively studied 243 NIDDM outpatients (duration of diabetes 7.9±7.1, age 54.5±10.8, male 110 and fema1e 133) who had undertaken fundoscopic examination for diabetic retinopathy before April 1991. At the time of the examination, 70 patients had nonproliferative diabetic retinopathy (NPDR). Of those, 12 patients progressed to PDR and 58 patients did not. Clinical characteristics and laboratory findings of progressed group were compared with non-progressed group. Results: Of the 162 patients who were free of diabetic retinopathy at the initial examination, 18 patients progressed to diabetic retinopathy; the incidence rate of diabetic retinopathy was 34.9/1,000 person-yr. Of these, 1 patients had PDR (1.9/1,000 person-yr). After 2.6 years of mean follow-up, 12 out of 70 patients with initial NPDR progressed to PDR. The incidence rate of PDR in the patients with NPDR was 63.2/1,000 person-yr. Microalbuminuria, more severe weight loss, lower level of C-peptide and insulin therapy were associated with an increased 2.6-year risk of developing PDR. However, sex, smoking, use of antihypertensive drugs or aspirin, age, duration of diabetes and the mean fasting serum glucose, hemoglobin Al, cholesterol, systolic or diastolic blood pressure levels during the follow-up period were not associated with the progression to PDR. Forward stepwise multiple logistic regression analysis revealed that initial microalbuminuria and delta BMI are significant independent predictor for the progression to PDR. Conclusion: Microalbuminuria can be used as a predictor for progression to PDR. Lower level of C-peptide, more severe weight loss and current insulin use may be also the risk factors for progression to PDR in Korean NIDDM patients with nonproliferative retinopathy. However, long-term prospective study is warranted to answer the question more properly.
김현철(Hyeon Chul Kim),신명철(Myung Choel Shin),이미화(Mee Wha Lee),이유미(You Me Lee),이위현(Wee Hyun Lee) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.9
Emergency cerclage commonly known as that performed in the setting of advanced cervical dilatation with bulging membranes and associated with significantly increased failure rates. We experienced a successful emergency cerclage for advanced incompetent internal os of cervix ( IIOC ). Pregnancy was prolonged and we delivered viable fetus. Hereby we report this case with the brief review of literature.
김숙경(Suk Kyung Kim),김현철(Hyeon Chul Kim),신승주(Seung Joo Shin),이미화(Mee Wha Lee),이유미(You Me Lee),조진호(Jin Ho Cho),최윤정(Yun Jung Choi),권계원(Kae Won Kwon) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.2
Campomelic syndrome is a very rare skeletal dysplasia with a characteristic pattern of deformity involving the proximal and distal extremities, pelvic and shoulder girdles, thoracic cage and palate. Respiratory compromise often leads to death in early infancy. Etiology has not been determined although evidence suggests genetic heterogeneity. Cytogenetic study revealed high incidence of a 46,XY karyotype in phenotypic females. Recently, we had experienced a case of campomelic dysplasia at amenorrhea 30weeks and termination was done, so we report with a brief review of literature.
김수진 ( Su Jin Kim ),정은호 ( Eun Ho Jeong ),김지연 ( Ji Yeon Kim ),이미화 ( Mee Wha Lee ),심성신 ( Sung Shin Shim ),이용희 ( Yong Hee Lee ),손석우 ( Suk Woo Son ),신승주 ( Seung Ju Shin ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.9
Fetus in fetus is a rare pathologic feature consisting of a parasitic twin included within the body of the other twin, which most likely arises from inclusion of a monozygotic, diamniotic twin pregnancy. The exact embryogenesis of fetus in fetus is cont