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멀티미디어 게임을 활용한 환경수업이 초등학생의 외래생물에 대한 인식, 학습동기 및 성취도에 미치는 영향
박성경 ( Sung Kyong Park ),배진호 ( Jin Ho Bae ),심규철 ( Kew Cheol Shim ),여성희 ( Sung Hee Yeau ),소금현 ( Keum Hyun So ) 한국초등과학교육학회 2013 초등과학교육 Vol.32 No.3
The purpose of this study was to develop a multimedia game program as a strategy for teaching alien species and to examine the effect of the program on recognition, motivation and achievement about alien species. In order to find the effect of developed program, 62 students among 6th graders at S Elementary School located in Gyeonggi-do were divided into two groups. Lesson with multimedia game was given to the experimental group, and the control group received traditional lesson. The results were as follows. First, the experimental and control groups showed significant difference in recognition of alien species. Second, the two groups showed statistically significant difference in learning motivation. For the subdomains of the recognition, significant results were obtained at the significance in attentiveness, relevance, confidence and satisfaction. Third, the two groups showed significant difference in academic achievement. Lastly as a result of interviewing subjects of the experimental group about lesson based on game, subjects generally had positive opinions that the new learning method is interesting and has helpful influence on the lesson.
PVP분자량에 따른 염산메트포르민 정제의 특성 및 방출거동
김대성 ( Dae Sung Kim ),성경열 ( Kyong Yeol Seong ),김원 ( Won Kim ),홍희경 ( Hee Kyung Hong ),안식일 ( Sik Il Ahn ),박종학 ( Jong Hak Park ),오재민 ( Jae Min Oh ),김윤태 ( Yun Tae Kim ),이은용 ( Eun Yong Lee ),이동원 ( Dong Won 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
In this study, metformin HCl, a highly water soluble anti-hyperglycemic agent was prepared into tablet type with PVP of various molecular weights(Mw) to effective oral administration. Because dissolution rate of drug with Mw of PVP becomes decreased as increasing Mw of PVP. We used magnesium stearate as lubricants. We compared the in vitro release behavior of metformin from the tablets according to additives with commercial drug, Diabex(R). The change of structure and crystallinity of tablet by additives were characterized by fourier-transform infrared spectroscopy(FT-IR) and differential scanning calorimeter(DSC). FT-IR and DSC results demonstrate that structure of drug was changed and crystallinity of drug was decreased according to decreasing Mw of PVP. The dissolution rate of metformin HCl from tablet decreased in simulated gastric fluid(pH 1.2) and simulated intestinal fluid(pH 6.8) as increasing K value of PVP. This study suggests Mw of pharmaceutical exipients could effect the metformin HCl release behavior.