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The Changes of CTX, DPD, Osteocalcin, and Bone Mineral Density During the Postmenopausal Period
박석교,정성욱,이재현,류상형,정호중,심영주,김동규,김기찬 대한재활의학회 2018 Annals of Rehabilitation Medicine Vol.42 No.3
Objective To investigate appropriate treatment time and useful bone turnover markers (BTMs) for monitoring bone turnover during the postmenopausal period, we analyzed changes of two bone resorption markers; serum carboxyterminal telopeptide of collagen I (s-CTX), urine deoxypyridinoline (u-DPD), one bone formation marker; serum osteocalcin (s-OC), and bone mineral density (BMD) in Korean postmenopausal women.Methods Seventy-eight menopausal women were divided into three groups according to postmenopausal period: group I (0–5 years), group II (6–10 years), group III (≥10 years). All groups were subdivided into an osteoporosis group (T-score≤-2.5) and a non-osteoporosis group (T-score>-2.5). BTMs such as s-CTX, u-DPD, s-OC, and BMD (g/cm2) were measured by dual-energy X-ray absorptiometry (DXA) in all patients. Analysis of variables among groups based on the postmenopausal period was performed using ANOVA.Results There was significant negative correlation between BMD and postmenopausal period. The levels of all BTMs including s-CTX, u-DPD, and s-OC were highest in group II and the increased levels of all BTMs subsequently declined in group III. The levels of BTMs were higher in the osteoporosis groups than in the non-osteoporosis groups in all subjects. It was statistically significant that the level of s-CTX in group I was higher in the osteoporosis group than in the non-osteoporosis group.Conclusion This study showed that bone resorption and bone formation were the highest 5–10 years after menopause, and s-CTX is more useful than u-DPD among the bone resorption markers. It’s important to measure serially both BMD and BTM within 10 years after menopause for accurate diagnosis and management for postmenopausal osteoporosis.
박현덕(Hyun-Duk Park),홍석교(Suk-Kyo Hong),좌동경(Dong-Kyoung Chwa) 대한전기학회 2009 정보 및 제어 심포지엄 논문집 Vol.2009 No.10
This paper presents an analytical fault detection and diagnosis method. By combining Luenberger Observer based method with parity equation method, the residual generator becomes robust to disturbances and it presents information of disturbance effect. From the comparison of two different residuals we can estimate whether the false alarm occurred or not.
김희동,김동규,채유경,박석교,김기찬,정호중,심영주,안예찬 한국광학회 2017 Current Optics and Photonics Vol.1 No.2
To investigate the usefulness of optical coherence tomography (OCT) for imaging lymphedema, wedirectly compared it to other histological methods in a mouse model of lymphedema. We performed detailedimaging of the lymphedema lesion on a mouse tail. We imaged the mouse tail in vivo with OCT andcreated histopathological samples. We constructed a spectrometer-based OCT system using a fiber-opticMichelson interferometer. The light was directed to 50:50 couplers that split the light into reference andsample arms. Backscattered light from a reference mirror and the sample produced an interference fringe. An OCT image of the lymphedema model revealed an inflammatory reaction of the skin that wasaccompanied by edema, leading to an increase in the light attenuation in the dermal and subcutaneous layers. Similar to OCT image findings, histological biopsy showed an inflammatory response that involved edema,increased neutrophils in epidermis and subdermis, and lymphatic microvascular dilatation. Furthermore, thelymphedema model showed an increase in thickness of the dermis in both diagnostic studies. In the mousetail model of lymphedema, OCT imaging showed very similar results to other histological examinations. OCT provides a quick and useful diagnostic imaging technique for lymphedema and is a valuable additionor complement to other noninvasive imaging tools.
정성욱,김기찬,정호중,김동규,홍유라,김휘동,박석교,심영주 대한재활의학회 2017 Annals of Rehabilitation Medicine Vol.41 No.5
Objective To identify the usefulness of both the Bayley Scales of Infant and Toddler Development, 3rd edition (Bayley-III) and Denver Developmental Screening Test II (DDST-II) in preterm babies with neurodevelopmental impairment, considering the detection rate as regulation of criteria.Methods Retrospective medical chart reviews which included the Bayley-III and DDST-II, were conducted for 69 preterm babies. Detection rate of neurodevelopmental impairment in preterm babies were investigated by modulating scaled score of the Bayley-III. The detection rate of DDST-II was identified by regarding more than 1 caution as an abnormality. Then detection rates of each corrected age group were verified using conventional criteria.Results When applying conventional criteria, 22 infants and 35 infants were detected as preterm babies with neurodevelopmental impairment, as per the Bayley-III and DDST-II evaluation, respectively. Detection rates increased by applying abnormal criteria that specified as less than 11 points in the Bayley-III scaled score. In DDST-II, detection rates rose from 50% to 68.6% using modified criteria. The detection rates were highest when performed after 12 months corrected age, being 100% in DDST II. The detection rate also increased when applying the modified criteria in both the Bayley-III and DDST-II.Conclusion Accurate neurologic examination is more important for detection of preterm babies with neurodevelopmental impairment. We suggest further studies for the accurate modification of the detection criteria in DDST-II and the Bayley-III for preterm babies.