염증성 치은조직에서 Cell Adhesion Molecule의 발현에 관한 연구

박경근,김은철,유형근,신형식,Park, Kyung-Geun,Kim, Eun-Chul,You, Hyung-Keun,Shin, Hyung-Shik 대한치주과학회 1996 Journal of Periodontal & Implant Science Vol.26 No.3

The change in vascular adhesion molecule expression and number of infiltrating leukocytes were investigated irnmunohistochemically in clinically healthy and inflammed gingiva. Monoclonal antibodies to ICAM-1, VCAM-1 and E-cadherin were used to identify positive vessels and leukocyte within gingival biopsies. 10 healthy gingiva and 30 inflammed gingiva was resected by clinical crown lengthening and modified Widman flap operation, respectively. Leukocyte entry into tissues at sites of inflammation is controlled by the interaction between adhesion molecule and endothelium. Because of rapid and severe destructive periodontal disease that is remarkable leukocyte adhesion deficiency, it is very important to unerdstand the mechanism of host defence against periodontal disease. The purpose of this investigation was the characterization of the presence and distribution of the adhesion molecule(ICAM-1, VCAM-1 and Evcadherin) in inflammatory gingival tissues compared to clinically healthy gingiva. The results were as followed; 1. ICAM-1 was distributed on basal layer, endothelium and mononuclear cells 10 healthy gingiva but inflammed gingiva was observed stronger stain than healthy gingiva. 2. Rare expression was observed in both group but few positive VCAM-1 cells were investigated in inflammatory gingival tissues 3. E-cadherin was expressed in only epithelium and reduced expression was observed in inflammatory gingival tissues. ICAM-1, VCAM-1 showed more expression in inflammatory tissues compared to healthy gingiva. Conversely, E-cadherin revealed a opposite result. These finding demonstrate a characteristic distribution and degree of adhesion molecule in healthy and inflammatory gingival tissues. But it is suggested that more detail study be progressive associated with leukocyte adhesion molecule to determine characterization of periodontal disease.

서울 북부 대보화강암 산지 암석의 풍화특성

박경근 ( Kyung Geun Park ),황상일 ( Sang Ill Hwang ),윤순옥 ( Soon Ock Yoon ) 한국지형학회 2015 한국지형학회지 Vol.22 No.2

Determination of degree of chemical weathering in stone cultural heritage is very hard, because of the difficulties to collect the samples from the protected site. Samples, biotite granite, collected from the mountains of northern Seoul to find the chemical properties and moisture contents. The results are used to examine the relationship between the physical properties of water and condition of the rock chemical weathering index(CIA, WPI). The WAR values of rocks used in the study are 1.53~3.28% of Mt. Dobong, 1.21~3.77% in Mt. Bukhan, 0.96~2.94% at Mt. Surack, and 1.87~3.03% of Mt. Bulam, respectively. The CIA values of this study are found as 49.71~57.63 for Mt. Dobong samples, 50.54~54.30 for Mt. Bukhan samples, 48.97~55.42 for Mt. Surack samples, and 50.08~55.07 for Mt. Bulam samples. In the case of WPI, it is found as 6.53~9.7 for Mt. Dobong, 7.29~8.81 for Mt. Bukhan, 7.62~10.45 for Mt. Surack, and 7.95~9.17 for Mt. Bulam. While the WAR values are increased, CIA values are increased within the range of 45~55 and WPI values are decreased. There is no clear relationship between the WAR and weathering index, so there is strong needs for further studies to find the relationship between WAR and weathering index.

췌장의 낭성종양 2예

박경근(Kyung Geun Park),이옥찬(Ock Chan Lee),함준수(Joon Soo Ham),이민호(Min Ho Lee),이동후(Dong Hoo Lee),기춘석(Choon Suhk Kee),박경남(Kyung Nam Park) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.4

Cystadenomas of the pancreas are uncommon tumors accounting for 5 to 15 percent of pan- creatic cystic lesions with less than 300 exarnples of this entity having been reported in the lit- erature. Cystadenomas are subdivided into microcystic adenoma(serous cystic adenoma) and mucinous cystic adenoma, the former does not appear to have any malignant potential, while the latter has to be considered as potentially malignant. Microcystic adenoma occurs in elderly patients, is twice as common in wornan, and originates from any location in the pancreas. In contrast, rnucinous cystic adenoma prevails in middle aged woman and is located most fre- quently in the body and tail of the pancreas. The tumors are discovered by chance during in- vestigation for causes of the pains. In some cases, the cyst may compress adjacent structures but a palpable mass is uncommon findings. The diagnosis may be suspected clinically, on ultra- sonography, computed tomography and endoscopic retrograde cholangiopancreaticography. We report each case of microcystic adenoma and mucinous cystic adenoma of the pancreas in 31 years old female and 57 years old female with a review of the literatures. (Korean J Gas- troenterol 1994; 26: 751 757)

목포시 부흥산 일대에 분포하는 타포니의 발달 특성과 풍화 과정

박경근(Park, Kyung Geun),신재열(Shin, Jae Ryul) 한국지역지리학회 2019 한국지역지리학회지 Vol.25 No.2

본 연구는 전라남도 목포시 부흥산 일대에 발달하는 타포니를 대상으로 그 발달 특성과 풍화 과정을 고찰하고 있다. 이를 위해 함수율 측정 및 XRF, XRD 분석과 수질 분석을 실시하였다. 분석 결과, 타포니의 발달에 있어서 사면향, 식생의 밀생정도, 풍향 등은 특히 발달 초기 단계에 중요한 영향을 미치는 요인인 것으로 판단되며, 함수율 측정, XRD 분석 및 화학적 풍화 지수(CIA) 등의 결과를 종합하면 타포니 발달 및 암석 풍화 과정에는 물리-화학적 풍화 작용이 복합적으로 영향을 미치는 것으로 생각된다. 또한 XRF 분석 결과 나타나는 높은 Na와 Cl 값은 인접한 해안으로부터 공급된 해염(NaCl)이 침전된 것으로 판단되어, 염 풍화 작용에 의한 암석 풍화 과정도 간접적으로 확인된다. This study identifies the distribution of tafoni at Mt. Buheung in Mokpo, Jeollanam-do and examines its developmental characteristics. For this purposes, measurement of water content rate, XRF, XRD and water analysis were performed. As a result, the distribution of taponi is judged to be primarily affected by the direction of slope, degree of vegetation, wind direction. Also, it is judged by the water content rate, XRD analysis, and the chemical weathering index (CIA) that physical-chemical weathering processes has a complex effect on the development of tafoni in the study area. The high Na and Cl values by XRF analysis indicates sedimentation of sea salt (NaCl) supplied from the adjacent coast.

담석에서 추출한 단백질의 분석

함준수(Joon Soo Hahm),박경근(Kyung Geun Park),박준용(Joon Yong Park),한동수(Dong Soo Han),이민호(Min Ho Lee),기춘석(Choon Suhk Kee),박경남(Kyung Nam Park),이광수(Kwang Soo Lee),최은아(Eun A Choi),이명규(Myung Kyo Lee),함경수(Kyung So 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1

N/A Background/Aims: Biliary proteins have been suggested to play an important role in nucleation and gallstone formation. However, the exact roles and characteristics have not been completely documented. The aim of the present study is to isolate and characterize the nucleating protein extracted from gallstones. Methods: We tried to extract, isolate and characterize proteins in patients with gallstones. Twenty-two gallstones were obtained(12 cholesterol, 10 pigment) at cholecystec- tomy and extracted with ethanol/ether mixture. Then, isoelectric focusing was performed and gallstone proteins were analysed by SDS-polyacrylamide gel electrophoresis. The amino acids were also analysis by the autoamimo acid analyzer system. Results: The mean amount of gallstone protein was 4.15 mg/(g stone) in cholesterol and 16.15 mg/(g stone) in pigment stone. The proteins from both cholesterol and pigment stones showed major bands at low pH on isoelectric focusing. On SDS-PAGE, low molecular protein bands were noted, mainly below 45KD in both cholesterol and pigment stones. The composition of aspartate and glutamate was 21.6% in cholesterol stones and 22.7% in pigment stones. Conclusions: The proteins in cholesterol and pigment gallstones are low molecular weight acidic proteins, and these acidic proteins seem to play an important role in the pathogenesis of gall stones. However, it remains to be determined whether these proteins differ in functional roles from different gallstones. (Korean J Gastroenterol 1996;28: 92 - 100)

포항시 흥해읍 일대 해안단구 제1면의 구정선 고도와 형성 시기

신재열(Shin, Jae Ryul),박경근(Park, Kyung Geun) 한국지역지리학회 2016 한국지역지리학회지 Vol.22 No.3

본 연구는 포항시 흥해읍 일대에 분포하는 해안단구 제1면의 구정선 고도를 밝히고 형성 시기에 관한 절대연대 자료를 제시하고 있다. 연구 결과, 구정선 고도 10 m의 해안단구 제1면은 10만 년 BP 내외의 MIS 5c 시기에 형성되 었으며 이후 MIS 5a 해퇴 시기까지 파랑의 퇴적작용을 반복적으로 받은 것으로 해석된다. 이러한 연구 결과는 해안 단구 제1면의 형성 시기에 관한 기존의 자료들을 교차 검증하는 한편 기존의 연구 결과들에 대한 종합적 검토를 바탕 으로 이루어진 것으로 동해안 지역 해안단구 제1면에 대한 사실을 재확인시켜 주고 있다. 한편 본 연구에서는 지형 대비를 통한 제4기 후기(MIS 5c) 동해안 지역의 고해수준을 추론하고 있으며 보다 정교한 분석을 위해서는 우선적으 로 해안단구 제2면의 구정선 고도에 관한 명확한 설정이 선결되어야 하겠다. This study documents the altitude of paleo-shoreline and formation age of the 1<SUP>st</SUP> marine terrace emerged around Heunghae-eup Pohang City (South Korea). As a result, the 1<SUP>st</SUP> terrace representing 10 m of the paleo-shoreline was formed at MIS 5c around 100,000 BP and was influenced repetitive sedimentation of sea-wave till regression of MIS 5a. The result is recognized as a definite truth for the 1<SUP>st</SUP> terrace in the eastern coast of the Korean peninsula based on synthetic reviews of previous studies and cross-validation of absolute age data. Furthermore, this study deduces a sea stand at MIS 5c from the geomorphological contrast method, but precise determination of paleo-shoreline of the 2<SUP>nd</SUP> terrace should be required to estimate that of MIS 5c.

독도 동도 서쪽 해안의 타포니 지형 발달

황상일(Sang Ill Hwang),박경근(Kyung Geun Park) 한국지역지리학회 2007 한국지역지리학회지 Vol.13 No.4

독도는 일본과의 영토문제와 관련하여 정치적, 역사적으로 관심의 대상이며, 울릉도와 더불어 동해상에 노출된 화산섬으로서 동해의 형성과정을 설명하는데 중요한 단서를 제공할 수 있을 뿐 아니라 해안지형 및 기반암 풍화지역이 넓게 분포하므로 지형학적으로 중요한 의미를 지닌다. 본 연구에서는 독도에서 가장 광범위하게 분포하며 독도의 전체 지형을 이해하는데 중요한 요소들 가운데 하나인 타포니 지형 발달을 논의하였다. 타포니는 독도의 거의 모든 해안에 분포하며, 노출된 기반암을 삭박하고 있으므로 독도의 보전에 있어서 가장 주목하여야 하는 지형들 가운데 하나이다. 동도 서해안에서 이 지형은 기반암이 응회암으로 된 해안선 부근에 집중적으로 나타난다. 타포니의 형태는 괴상각력응회암 층준에서는 불규칙한 모양이 주를 이루며 원형, 타원형 형태가 나타나고, 층상라필리응회암에서는 층리를 따라서 수평으로 길게 만들어 졌다. 독도의 타포니는 홀로세(Holocene) 중기 해면이 현재 수준에 도달한 이후 파식에 의해 만들어진 해식애의 표면에 분포한다. 염풍화 작용에 의해 형성된 타포니는 독도의 지형 해체에 가장 크게 기여하는 요인들 가운데 하나이다. 타포니의 바닥에는 초본 식물들이 분포하며 조류들의 서식처로서 중요한 역할을 한다. 타포니의 발달에 의한 기반암의 해체를 지체시키기 위해서는 토양 및 식생의 보호가 가장 중요하다. Dokdo has historical and political meaning in relation to the territorial problems with Japan. The area can be the main factor to explain the formation and development process of East-Sea as exposure volcanic island at East-Sea with Ulreong-island. Accordingly, it also has an important meaning of physical geography aspects In this research, it is perceived the geomorphological development process of slope due to the salt weathering which is considered as the most important factor to understand whole geomorphology of Dokdo. And researched how a geomorphology of this sort affects to animal and plants. The peculiar geomorphology is tafoni which is a weathering geomorphology and one of the remarkable geomorphology in preservation of Dokdo. Tafoni at west part of Dongdo is distributed intensively near shoreline which is composed tuff. The shape of tafoni is mainly massive, circle and oval in Massive tuff breccia layer also is formed toward horizontality bedding direction in Bedded lapilli tuff. Tafoni in Dokdo is constituted after middle of Holocene. This fact can be proved by ranging at surface of sea-cliff which is formed wave erosion after middle of Holocene sea-level reaching to present level. Tafoni is also the most contribute factor of geomorphology dissection of Dokdo as it is eroded the bed rock with salt weathering. In bottom part of tafoni it has an important function for habitat of birds. Herbaceous plants are on it. To procrastinate of bed rock dissection by growth of Tafoni, conservation of vegetation and soil are most important factor.

당뇨병환자에서 담석증의 빈도 및 특성에 관한 연구

박준용(Joon Yong Park),한동수(Dong Soo Han),윤병철(Byung Chul Yoon),이오영(Oh Young Lee),손주현(Joo Hun Sohn),함준수(Joon Soo Hahm),박경근(Kyung Geun Park),김정현(Jeogn Hyun Kim),이민호(Min Ho Lee),기춘석(Choon Suhk Kee),박경남(Kyung 대한소화기학회 1995 대한소화기학회지 Vol.27 No.4

N/A Background/Aims: Diabetes mellitus is thought to be a risk factor for gallstone diseases, esopecially cholesterol stone. The risk of cholelithiasis among diabetic persons cou]d be due to several mechanisms, including impaired gallbladder motility and hyperinsulinemia. We investigated the relationship of gallstones in the diabetic patients and analyzed their clinical course and related factors. Methods: A collective review of ] 1,302 diabetic patients from January l979 to December 1993 were carried out at Hanyang University Hospital. Of the 323 cases with gallstones, 180 cases were evaluated for age, body mass index, duration of disease, HbAlc, fasting blood sugar, AST/ALT, cholesterol level and triglyceride level. Results: The prevalence of gallstones in the diabetics studied was 2.86%. The composition of gallstones was not related to age, and pigmented stones were most commonly observed. The incidence c>f cholecystectomy was 0.27% in men, and 0.47% in women. Conclusions: The prevalence of gallstones in diabetic patients was higher than in the normal population, which could be explained by the decreased mcotility of the gallbladder or obesity. No significant difference was found in age, body mass index, cholesterol level, and triglyceride level when compared to patients with or without gallstones. (Korean J Gastroenterol 1995;27:433 - 440)

담석의 병인에 있어서 담낭수축 기능의 의의에 관한 연구

이옥찬(Ock Chan Lee),박경근(Kyung Geun Park),안유헌(Yoo Hern Ahn),임헌길(Heon Kil Rhim),함준수(Joon Soo Hahm),이민호(Min Ho Lee),기춘석(Choon Suhk Kee),박경남(Kyung Nam Park) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.1

N/A Gallstone is the most common disease in the biliary system, and the incidence is increasing gradually. Furthermore, the composition of stones in Korea seems to be changed to approach that of stones formed in the west. Factors responsible for this change may include rapidly pro- ceeding urbanization and changing food habits. The method of medical therapies for gall- stones is also increasing and results in a number of clinical studies for pathogenesis of gall- stones such as stasis, supersaturation, and crystal formation of bile juice. We studied for 40 subjects, healthy controls were 20 (11 male, 9 female: mean age, 44.45 years, mean body mass index, 24.07), and gallstone patients were 20 (1 1 male, 9 female: mean age, 54.7 years, mean body mass index, 22.78). The gallbladder volumes were measured by real time ultrasonography using the ellipsoidal method. And then, we calculated ejection fraction (EF) by these results. The results were expressed as mean + standard deviation, and differ- ence in the mean values of each group were evaluated by the Students t test. Statistical sig- nificance was assigned if P was <0.05. There was no significant difference between gallstone patients and healthy controls in age, body mass index, and biochernical laboratories. Both fasting gallbladder volume and ejection fraction were not different between obese and non obese group. However, ejection fraction in gallstone patients was significantly lower than normal controls in obese group. Ejection frac- tion(EF, %) was significantly greater in controls than gallstone patients. No significant differ- ences were observed in fasting gallbladder volumes between gallstone patients and healthy controls, but gallbladder volume after fatty meal was significantly larger in gallstone patients than control subjects. Fasting gallbladder volumes were significantly reduced after fatty meal in both groups. The gallbladder motility rnay play a role on gallstone formation, and the estimation of its motility may be an important factor in deterrnining the response to medical therapy.(Korean J Gastroenterol 1994; 26: 143 150)

독도 서도 북서 해안의 Holocene 기후변화와 타포니 지형발달

황상일 ( Sang Il Hwang ),박경근 ( Kyung Geun Park ),윤순옥 ( Soon Ock Yoon ) 한국지형학회 2009 한국지형학회지 Vol.16 No.1