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문홍상,이정우 한양대학교 의과대학 2014 Hanyang Medical Reviews Vol.34 No.2
Depressive disorders have an overall incidence of 2-15%, and are among the most common mental illnesses. Depression is currently considered to be the fourth leading cause of premature death or disability, and it is expected to become the second leading cause of disease burden by 2020. It is closely related with the pathogenesis of many chronic diseases. Recently, some studies have shown the correlation of depressive disorders with lower urinary tract symptoms (LUTS) caused by benign prostatic hypertrophy, overactive bladder and other urological diseases. It is still unknown exactly what mechanism is the link between concomitant depression and LUTS, however differences in levels of antidiuretic hormone, inflammatory cytokines, phosphodiesterase isoenzyme and serotonin have been identified in patients suffering from depressive symptoms with LUTS. Numerous cross sectional studies and prospective cohort epidemiological investigations performed around the world have failed to demonstrate a clear causative mechanism for the relationship due to various limitations. Concomitant depression with LUTS creates a vicious cycle of suffering that significantly lowers the quality of life for patients. Further research is warranted to prevent progression of disease and improve the clinical outcome for patients with LUTS and associated depressive disorder.
음경에 Methamphetamine 주사 후 발생한 Fournier Gangrene
문홍상,이장현,최홍용,박해영 대한남성과학회 2010 The World Journal of Men's Health Vol.28 No.3
Fournier gangrene is a fulminant infection of the genitalia, perineum, or abdominal wall. It is a life threatening progressive disease that requires aggressive surgical therapy and broad spectrum antibiotic treatment. We present one case of Fournier gangrene after penile methamphetamine injection.
문홍상,김규식,정원식,박성열,김용태 대한남성과학회 2015 The World Journal of Men's Health Vol.33 No.1
Purpose: Dutasteride affects the prostate by reducing intraprostatic dihydrotestosterone and prostate tissue vascularity. We evaluated the effect of pretreatment with dutasteride for two weeks on perioperative and postoperative bleeding during transurethral resection of the prostate (TURP).Materials and Methods: Eighty-three patients who had benign prostatic hyperplasia together with the criteria for eligibility for TURP were included. The dutasteride group consisted of 40 patients who were treated with dutasteride (0.5 mg/d) for two weeks before surgery, and the control group consisted of 43 patients who did not receive dutasteride. Blood loss was evaluated in terms of reduction in serum hemoglobin (Hb) and hematocrit (Hct) levels, which were measured before, immediately after, and 24 hours after surgery. We also measured the durations of indwelling urethral catheter use, continuous saline bladder irrigation, and hospitalization.Results: Lower mean blood loss was observed in the dutasteride group than the control group immediately after and 24 hours after surgery (ΔHb=0.65±1.27 g/dL vs. 1.16±0.73 g/dL, 1.30±1.00 g/dL vs. 1.86±1.05 g/dL respectively, p=0.019, p=0.011; ΔHct=1.89%±3.83% vs. 3.47%±2.09%, 3.69%±2.95% vs. 5.39%±3.23% respectively, p=0.016, p=0.011). In addition, there were fewer days of indwelling urethral catheter use (2.95 ±1.02 d vs. 3.92 ±1.14 d, p=0.000), continuous saline bladder irrigation (1.81 ±1.08 d vs. 2.36 ±1.06 d, p=0.016), and hospitalization after TURP (3.95 ±1.09 d vs. 4.76 ±1.19 d, p=0.001) in the dutasteride group.Conclusions: Preoperative treatment with dutasteride for two weeks before TURP reduces surgical bleeding and length of hospitalization after TURP. This pretreatment can be used to decrease surgical bleeding associated with TURP.