치매에 관한 최근의 연구 동향

나창수,김정상,채우석,박석천,Na, Chang-Su,Kim, Jeong-Sang,Chae, U-Seok,Park, Seok-Cheon 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.1

Dementia is the neurodegenerative process that affects cognition, behavior and function and one of the most prominent diseases of dementia is Alzheimer's disease(AD). AD is a dementing illness characterized clinically by the progressive and irreversible deafferentation of the limbic system, association neocortex and basal forebrain. A number of conditions are known to be predisposing risk factors for AD. In several of these, initiation of glial-mediated inflammatory pathways as a mechanism of AD is getting a lot of attention. On the other hand, a biochemical marker for monitoring the onset and progression of the disease would be a valuable tool for disease management. Also such a marker might be used as an end point in clinical intervention protocols. This biochemical marker will have the potential for identifying subjects afflicted with the disease and possibly for monitoring the onset and longitudinal progression of the disease. Here we have reviewed the latest papers of different approaches to AD. Of course, there is a section of PET which is very useful clinically nowadays.

신문(神門), 태백혈(太白穴)에 시행된 직자법(直刺法), 수기사법(手技瀉法)및 침습형 레이저 시술이 고혈압 백서에 미치는 영향

나창수 ( Chang Su Na ),윤대환 ( Dae Hwan Youn ),최찬헌 ( Chan Hun Choi ),이석희 ( Suk Hee Lee ),오광환 ( Kwang Hwan Oh ),정성호 ( Sung Ho Jeong ) 대한경락경혈학회 2008 Korean Journal of Acupuncture Vol.25 No.2

Objectives: This study was performed to investigate the effect of invasive Laser acupuncture therapy with green Light (LAT-G) at HT7(Sinmun), SP3(Taebaek) on the blood pressure in hypertensive rat induced by two kidney one clip. Methods: The experiments were performed on Sprague Dawley rats. 2K1C hypertension model was prepared by constricting the Left renal artery with a sliver clip. Animals were divided into four groups, which were simple acupuncture treatment group with straight needle insertion on the square(AT-SS), acupuncture treatment group with reducing manipulation in the opposite channel direction(AT-RD), Laser acupuncture treatment group with green Light 532 nm, 10mW power in the opposite channel direction(LAT-G10) and Laser acupuncture treatment group with green Light 532 nm, 20mW power in the opposite channel direction(LAT-G20). The treatments were performed once per two days for 10 days. Results: Body weight was increased significantly in LAT-G20 group compared with AT-RD group. The blood pressure was significantly decreased in LAT-G20 and LAT-G10 groups compared with AT-SS group. Conclusions: These results suggest that green Laser acupuncture therapy at SP3·HT7 is more effective than straight needle insertion on the square for controlling hypertension. It is possible that invasive green Laser acupuncture therapy (532 nm) can be used as a reducing method of the traditional acupuncture techniques.

합곡(合谷) 복류(復溜) 보사(補瀉) 시술(施術)이 소한(少汗)에 미치는 영향(影響)(II)

나창수,최찬헌,김영선,김왕인,윤대환,Na, Chang-Su,Choi, Chan-Hun,Kim, Young-Sun,Kim, Wang-In,Youn, Dae-Hwan 경락경혈학회 2010 Korean Journal of Acupuncture Vol.27 No.2

Objectives : The purpose of this study is to identify the effect of tonifying or sedative manipulation on LI4 and KI7 for sweet deficiency under cold environment. Methods : The participants were divided into 4 groups; intact group without acupuncture(Intact), acupuncture group inserting straightly with LI4 & KI7 method((LI4-straight KI7-straight), acupuncture group inserting twisting with LI4 tonificaton & KI7 tonificaton method(LI4-tonify KI7-tonify) and acupuncture group inserting twisting with LI4 sedation & KI7 sedation method(LI4-purge KI7-purge). We obtained the baseline data under cold condition with the temperature $14{\pm}1^{\circ}C$. After making the participant staying under cold condition for 10 minute, we measured sweating rate on skin surface and biological responses such as body temperature, oxygen saturation, pulse rate, systolic blood pressure, diastolic blood pressure, deoxy-Hb and oxy-Hb in subcutaneous. Results : The sweating rate on skin surface was not different in all treatment groups compared to the intact group. The body temperature was significantly increased in LI4-straight KI7-straight group compared to the intact group. The oxygen saturation significantly increased in LI4-purge KI7-purge group compared to the intact group. The systolic blood pressure was significantly increased in LI4-purge KI7-purge group compared to the intact group. The deoxy-Hb was significantly decreased in LI4-purge KI7-purge group compared to the intact group. Conclusions : The above results, the effect of LI4, KI7 acupuncture due to the tonifying or sedative manipulation on sweating control could be observed. However, other biological responses with the acupuncture of tonifying or sedative manipulation were giving different expressions. We suggest that continued research of tonifying or sedative manipulation is of importance order to find these expressions.

합곡(合谷) 복유(復溜) 보사(補瀉) 시술(施術)이 소한(小汗)에 미치는 영향(影響)(2)

나창수 ( Chang Su Na ),최찬헌 ( Chan Hun Choi ),김영선 ( Young Sun Kim ),김왕인 ( Wang In Kim ),윤대환 ( Dae Hwan Youn ) 대한경락경혈학회 2010 Korean Journal of Acupuncture Vol.27 No.2

Objectives: The purpose of this study is to identify the effect of tonifying or sedative manipulation on LI4 and KI7 for sweet deficiency under cold environment. Methods: The participants were divided into 4 groups; intact group without acupuncture(Intact), acupuncture group inserting straightly with LI4 & KI7 method((LI4-straight·KI7-straight), acupuncture group inserting·twisting with LI4 tonificaton & KI7 tonificaton method(LI4-tonify·KI7-tonify) and acupuncture group inserting·twisting with LI4 sedation & KI7 sedation method(LI4-purge·KI7-purge). We obtained the baseline data under cold condition with the temperature 14±1℃. After making the participant staying under cold condition for 10 minute, we measured sweating rate on skin surface and biological responses such as body temperature, oxygen saturation, pulse rate, systolic blood pressure, diastolic blood pressure, deoxy-Hb and oxy-Hb in subcutaneous. Results: The sweating rate on skin surface was not different in all treatment groups compared to the intact group. The body temperature was significantly increased in LI4-straight·KI7-straight group compared to the intact group. The oxygen saturation significantly increased in LI4-purge·KI7-purge group compared to the intact group. The systolic blood pressure was significantly increased in LI4-purge·KI7-purge group compared to the intact group. The deoxy-Hb was significantly decreased in LI4-purge·KI7-purge group compared to the intact group. Conclusions: The above results, the effect of LI4, KI7 acupuncture due to the tonifying or sedative manipulation on sweating control could be observed. However, other biological responses with the acupuncture of tonifying or sedative manipulation were giving different expressions. We suggest that continued research of tonifying or sedative manipulation is of importance order to find these expressions.

배에서 추출된 Pectin과 Phenolic compound가 흰쥐의 국소뇌혈류 및 심혈관계에 미치는 영향

나창수 ( Chang Su Na ),윤대환 ( Dae Hwan Youn ),최동희 ( Dong Hee Choi ),정종길 ( Jong Gil Jeong ),은종방 ( Jong Bang Eun ),김정상 ( Jeong Sang Kim ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.2

N/A Objectives : Oriental pear was used as treating disorder of heart and blood circulation in oriental medicine. This study was designed to investigate that pear pectin, pear phenolic compound effects on cardiovascular system as regional cerebral blood flow(rCBF), mean arterial blood pressure(MAP), heart rate, cardiac contractile force. Methods : The experiments were performed on Sprague Dawley rats. 2K1C hypertension model was prepared by constricting the left renal artery with a sliver clip. Apple pectin, pear pectin and pear phenolic compound solutions were administrated via femoral vein for Sweeks, a day`s interval. Animals were divided into four groups, administration of apple pectin(AP1, pear pectin(PP) and pear phenolic compound( PPC ). Results : The results are that KBF was significantly increased at lmglkg in PPC group. The MAP was significantly decreased at l0㎍/kg in apple pectin, at l0㎍/kg, 100㎍/kg in pear pecitn than before adminstration, but increased at 1 m p d k g in pear phenolic compound. There was no significant effects in heart rate. Cardiac contractile force was significantly increased a at l0㎍/kg, l00㎍/kg, lmg/kg in pear phenolic compound. Conclusions : These results suggests that pear phenolic compound and pear pectin may be a significant effect in symptoms of heart and blood circulation..

고지혈증 유발 백서에서 열결 ${\cdot}$ 여구에 대한 침자 및 강도별 레이저조사가 체중, 식이효율, 지질대사 및 동맥경화지수에 미치는 영향

나창수,윤대환,조명래,강자돈,Na, Chang-Su,Youn, Dae-Hwan,Cho, Myung-Rae,Kang, Ja-Don 경락경혈학회 2007 대한침구의학회지 Vol.11 No.1

Objectives : This research was performed to investigate the effect of acupuncture using invasive low level laser therapy (LLLT) at Yolgyol (LU7) + Yogu (LR5) on weight gain, food intake, food efficiency, lipid metabolism, atherogenic index, HTR (HDL-cholesterol to total cholesterol ratio) and morphological change of hepatic tissue in hyperlipdemia rats. Methods : Experimental groups were divided into high fat diet group (Control group), high fat diet and acupuncture therapy group at LU7 + LR5 (AT group), high fat diet and acupuncture group using 10 mW LLLT at LU7 +LR5 (LA10 group), high fat diet and acupuncture group using 20 mW LLLT at LU7+LR5(LA20 group), high fat diet and acupuncture group using 60 mW LLLT at LU7 + LR5 (LA60 group), once per 3 days during 9 weeks. Results : Body weight was decreased significantly in AT and LA20 groups compared with Control group. Food intake was increased significantly in LA60 group compared with Control group. Food efficiency was decreased significantly in LA10, LA20 and LA60 groups compared with control group. In the lipid metabolism, total cholesterol was decreased significantly in AT, LA10, LA20 and LA60 groups, triglyceride was decreased significantly in LA10, LA20 and LA60 groups, TG/HDL-cholesterol ratio was decreased significantly in LA 60 group compared with control group. In the morphological change, hepatic tissue were not showed balloning degeneration and irregular arrangement of hepatic cell in LA10 and LA20 groups with control group. Conclusions : Acupuncture using LLLT at LU7+LR5 can manage hyperlipemia by controlling body weight, food intake, food efficiency ratio and lipid metabolism.

합곡(合谷), 족삼리(足三里) 단독 침자와 합곡(合谷)에 족삼리(足三里)를 배혈한 침자가 하치부 동통 억제에 미치는 영향

나창수 ( Chang Su Na ),왕국환 ( Kuk Hwan Wang ),김정상 ( Jeong Sang Kim ),윤여충 ( Yeo Chung Yun ) 대한경락경혈학회 2001 Korean Journal of Acupuncture Vol.18 No.2

The pain was induced on upper and lower incisor of the rat based on the theory of `connections of upper incisor pain with stomach meridian and lower incisor pain with large intestine meridian`. Such acupoints as LI4 and ST36 were used for alleviation of upper and lower incisor pain. The digastric myogram (dEMG) was utilized for the pain measurement. The upper incisor pain was gradually decreased during ST36 stimulation and significant differences were observed at 20 minutes point during 60 minutes study. The upper incisor pain was gradually decreased during LI4 acupuncture and 20 minutes point was the only point that showed a significant difference. The alleviation of lower incisor pain was not obvious during the ST36 acupuncture. The lower incisor pain was gradually decreased during LI4 stimulation with significant differences at 20 and 40 minutes point. In conclusion, the upper incisor pain was relieved with LI4 and ST36 acupuncture while LI4 was effective on the lower incisor pain alleviation based on the theory of `connections of upper incisor pain with stomach meridian and lower incisor pain with large intestine meridian`.

곤륜(崑崙),소부(少府) 침자(鍼刺)가 하장간막신경(下腸間膜神經) 활성(活性)과 혈압(血壓) 및 심박수(心搏數)에 미치는 영향(影響)

나창수 ( Chang Su Na ),리강욱 ( Kang Uk Lee ),윤여충 ( Yeo Chung Yun ),김정상 ( Jeong Sang Kim ) 대한경락경혈학회 2002 Korean Journal of Acupuncture Vol.19 No.2

Objectives: The aim of the present study is to observe effects of acupuncture related with the nerve system, Inferior mesenteric nerve activity(IMNA) was examined on BL60 acupuncture closely connected with the bladder and HT8 with little tied. Materials and methods: Acupunctures were performed during 100 seconds after stabilization. IMNA was measured by micromanipulator, preamplifier, mean arterial pressure(MAP) and heart rate were observed by blood pressure transducer, 4-channel transducer amplifier in anesthetized rat. Results: On BL60 acupuncture, the heart rate was not significantly decreased but IMNA, MAP were significantly decreased and Maximum peak of IMNA was increased during inserted acupuncture, decreased after ejected acupuncture respectively. On HT8 acupuncture, IMNA was decreased during acupuncture than before acupuncture but the others did not showed signigicant difference. Conclusions: Our results demonstrated a meridian interaction between BL60 acupoint in the bladder channel and Inferior mesenteric sympathetic nerve related to the bladder. This fact suggest that BL60 acupuncture have effect on the bladder through the nerve system. Meanwhile, IMNA was decreased during HT8 acupuncture. This result is supposed HT8 to have not meridian function but acupoint function by another mechanism. It needs to be closely examined other meridians and nerve by the optimal approaching method.

경옥고의 원방과 가미방 익수영진고가(加)꽃송이버섯이 항산화, 면역력 활성 및 기호도에 미치는 영향

나창수 ( Chang-su Na ),신욱 ( Wook Shin ),이유미 ( Yu-mi Lee ),문양선 ( Yang-seon Moon ),노희경 ( Hee-kyung Noh ),서승호 ( Seong-ho Seo ),손홍석 ( Hong-seok Son ) 대한본초학회 2016 大韓本草學會誌 Vol.31 No.4

Objectives: This study was conducted with objectives of comparatively investigating effects of original Kyungokgo and Iksuyongjingo plus Sparassis crispa which is gamibang of Kyungokgo on antioxidant improvement, immunity improvement, and sensory evaluation. Methods : Total phenol and DPPH scavenging activity were measured to determine antioxidant improvement of original Kyungokgo and Iksuyongjingo plus Sparassis crispa . While, blood and serum study were conducted and effect on the cytokines were observed from the immunosuppressed rat induced by methotrexate (MTX). Control group was administered with a drinking water, Kyungokgo group was administered with a original Kyungokgo 200 mg/kg, and Iksuyongjingo plus Sparassis crispa group was administered with a Iksuyongjingo plus Sparassis crispa 200 mg/kg for 20 days. Further, intensity and preference evaluation were performed as sensory evaluation. Results : It was observed that Iksuyongjingo plus Sparassis crispa significantly increased total phenol and DPPH scavenging activity, proving that these can improve antioxidant activities. In the immunosuppressed rat, Iksuyongjingo plus Sparassis crispa significantly decreased IL-2 level, significantly increased Il-10 level, and significantly increased neutrophils, RBC, HGB, and HCT levels, indicating that it is effective in increasing immunity. Further, Iksuyongjingo plus Sparassis crispa significantly improved intensity and preference in the sensory evaluation. Conclusions : From the above results, it is concluded that Iksuyongjingo plus Sparassis crispa which is gamibang of Kyungokgo can act effectively on improving antioxidant activity and immunity, and can attribute convenient intake by improving diet preference.

족삼리(足三里), 합곡(合谷) 침자(鍼刺)가 상치(上齒), 하치부(下齒部) 동통(疼痛) 억제(抑制)에 미치는 영향(影響)

나창수 ( Chang Su Na ),최동희 ( Dong Hee Choi ),김원재 ( Won Jae Kim ) 대한경락경혈학회 2001 Korean Journal of Acupuncture Vol.18 No.1

The pain was induced on upper and lower incisor of the rat based on the theory of `connections of upper incisor pain with stomach meridian and lower incisor pain with large intestine meridian`. Such acupoints as ST36 and LI4 were used for alleviation of upper and lower incisor pain. The digastric myogram (dEMG) was utilized for the pain measurement. The upper incisor pain was gradually decreased during ST36 stimulation and significant differences were observed at 20 and 25 minute point during 60 minutes study. The upper incisor pain was gradually decreased during LI4 acupuncture and 20 minute was the only point that showed a significant difference. The alleviation of lower incisor pain was not obvious during the ST36 acupuncture. The lower incisor pain was gradually decreased during LI4 stimulation with significant differences at 15, 20 and 40 minute point. In conclusion, the upper incisor pain was relieved with ST36 and LI4 acupuncture while LI4 was effective on the lower incisor pain alleviation based on the theory of `connections of upper incisor pain with stomach meridian and lower incisor pain with large intestine meridian`.