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Triclosan 을 배합한 세치제의 치은염완화효과와 치면세균막형성억제효과 및 구강질환원인균에 대한 항균효과에 관한 연구
김종배,문혁수,백대일,마득상,윤정원,박덕영,정세환,신미정,서우석 대한구강보건학회 1998 大韓口腔保健學會誌 Vol.22 No.2
A total of 62 adult male and female subjects began a 6-week, double-blind clinical study comparing the effect on gingivitis and plaque formation of a 0.2% triclosan-containing dentifrice to a placebo dentifrice. Placebo dentifrice had the same formulation with experimental dentifrice except it did not contain 0.2% triclosan. Subjects were divided by two balanced groups according to baseline plaque and gingivitis scores. Then, they were assigned to use either the the triclosan-containing dentifrice or the placebo dentifrice for the next 6weeks. Finally, 28 experimental and 24 control subjects completed 6 weeks of the study. Plaque index and gingival index were scored 3 times : before the study, after 4weeks of use of each dentifrice, after 8weeks of use of each dentifrice. Quigley-Hein Plaque index and Loe-Silness Gingival index were used to score each index. Also, the antimicrobial effects of a 0.2% triclosan-containing dentifrice against the pathogens of oral diseases such as Streptococcus mutans, Streptococcus sanguis, Lactobacillus acidophilus, Actinomyces viscosus, Fusobacterium nucleatum were evaluated with the agar dilution and paper disc methods. The results obtained were as follows: 1. After 6 weeks, the triclosan-containing dentifrice was shown to provide a 20.4% reduction in gingivitis, as compared to the placebo dentifrice, but not statistically significant(P>0.05). 2. After 6 weeks, the triclosan-containing dentifrice was shown to provide a statistically significant reduction in plaque formation, as compared to the placebo dentifrice(P<0.05). 3. The triclosan-containing dentifrice showed more effective antimicrobial activities on Lactobacillus acidophilus, Actinomyces viscosus, as compared to the placebo dentifrice.
Triclosan 과 Pyrophosphate 및 Tranexamic acid 를 배합한 세치제의 치주질환원인균과 구취유발원인균에 대한 항균효과에 관한 연구
김종배,문혁수,백대일,윤정원,정세환,신미정,이기현 대한구강보건학회 1998 大韓口腔保健學會誌 Vol.22 No.3
The antimicrobial effects of dentifrice containing triclosan, pyrophosphate and tranexamic acid against the pathogens of periodontal disease and halitosis such as Streptococcus sanguis, Actinomyces viscosus, Candida albicans, Actinobacillus actinomycetemcomitans, Capnocytophaga ochracea, Fusobacterium nucleatum, Prevotela intermedius, Phopyromonas gingivalis were evaluated with the agar dilution and paper disc methods. The results obtained were as follows: 1. Both the experimental dentifrice containing triclosan, pyrophosphate and tranexamic acid and the control dentifrice showed the antimicrobial activities on all the microorganisms tested. 2. The experimental dentifrice containing triclosan, pyrophosphate and tranexamic acid showed more effective antimicrobial activities on Actinobacillus actinomycetemcomitans, Capnocytophaga ochracea, Phopyromonas gingivalis, relative to the control dentifrice.
불화나트륨과 자일리톨배합양치액의 법랑질표면미세경도변화와 구취감소효과에 관한 연구
김종배,문혁수,백대일,정세환,배광학 대한구강보건학회 1998 大韓口腔保健學會誌 Vol.22 No.2
The microhardness changes of tooth enamel by mouthrinses was investigated in vivo using acrylic mandibular removable appliance. Three different mouthrinses which contained 1) 0.02% NaF 2) 0.05% NaF 3) 0.02% NaF + 10% Xylitol were tested. Early caries-like lesions were created using 0.1M lactic acidsodium hydroxide buffer(pH 4.0). Three enamel specimens with early caries-like lesions were mounted into the recesses of lingual surface of the appliance with sticky wax. 10 subjects wore the appliance for one hour after mouthrinsing two times per day. Each subjects wore the appliance for three separate 7-days period; 0.02% NaF mouthrinse, 0.05% NaF mouthrinse, 0.02% NaF + 10% Xylitol mouthrinse. Suface microhardness were checked by microhardness tester(Shimadzu corporation Model, HMV-2000 No. 33100410, Japan) before and after mouthrinse. In order to evaluate the effect of mouthrinses on reducing halitosis, the author had analysed the volatile sulfur compounds(VSC) in halitosis after the chewing of 0.5gm garlic powder by 10 subjects. Following mouth air sampling immediately after the chewing of garlic powder, subjects used mouthrinses and reevaluated at 5 and 10 minutes after chewing of garlic powder. The evaluation of methylmercaptan in mouth air was done by gas chromatographic technic. The percent change in methylmercaptan concentration of air samples were calculated in relation to values of mouth air sample immediately after chewing of garlic powder. The obtained results were as follows: 1. The change of surface microhardness in 0.02% NaF mouthrinse group did not showed significantly between before and after mouthrinse(P>0.05), but surface microhardness in 0.05% NaF mouthrinse group and in 0.02% NaF and 10% Xylitol mouthrinse group showed significantly between before and after mouthrinse(P<0.05). 2. The change of surface microhardness was higher in 0.05% NaF mouthrinse group and in 0.02% NaF and 10% Xylitol mouthrinse group than in 0.02%NaF mouthrinse group, but there was no significance statistically. 3. The mouthrinse containing 0.02% NaF and 10% Xylitol reduced more methylmercaptan than other experimental mouthrinses at 5 minutes after the chewing of garlic powder (P<0.05).
자몽종자추출물과 차추출물 및 UDCA 를 배합한 구내분무액의 S . mutans 와 구취 감소효과 및 치은염완화효과에 관한 연구
김종배,문혁수,백대일,박덕영,정세환,배광학 대한구강보건학회 1998 大韓口腔保健學會誌 Vol.22 No.1
The purposes of this study were to evaluate the effects of mouth spray containing GFSE, tea extract and UDCA on antimicrobial effect in Streptococcus mutans, reducing oral malodor and reduction of gingivitis, Three different mouth sprays which contained 1) 0.01% GFSE, 2) 0.01% GFSE + 0.10% tea extract, 3) 0.01% GFSE + 0.10% tea extract + 0.02%UDCA were tested. In this cross-over antimicrobial resistance study, 30 students aging 20 to 24 participated, There were three experimental periods continued one weeks each and two control periods betwen experimental periods. Colony count number of Streptococcus mutans in 0.1% peptone garggling solution were measured. In order to evaluate the effect of experimental mouth sprays on reducing oral malodor, the authors had analysed the volatile sulfur compounds(VSC) in mouth odor after chewing of 0.5㎎ garlic powder. Following mouth air sampling immediately after the chewing of garlic powder, subjects used mouth spray and re-evaluated at 3, 8, and 13 minutes respectively after chewing of garlic powder. Gas chromatographic technic was employed for the evaluation of VSC in mouth air. The percent change in VSC concentration of air samples were calculated in relation to values of mouth air sample immediately after the chewing of garlic powder. 40 subjects completed a two weeks, double blind clinical study of experimental mouth sprays on reduction of gingivitis, S ubjects were divided by three experimental and one control group. Gingival index were scored three times : 1) before dividing group, 2) after one weeks, 3) after two weeks. Gingival index which modified Lo¨e & Silness were used to score the gingivitis. The results obtained were as follows: 1. Mean counts of Streptococcus mutans of three experimetal mouth sprays containing GFSE, tea extract and UDCA were significantly decreased, as compared to that of the control mouth spray(P<0.05). 2. Three experimetal mouth sprays containing GFSE, tea extract and UDCA reduced more methylmercaptan than control mouth spray(P<0.05). 3. The experimetal mouth spray containing 0.01% GFSE, 0.10% tea extract, and 0.02% UDCA significantly reduced gingivitis, as compared to the control mouth spray(P<0.05).