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RISS 인기검색어
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- 저자 : 김조용(Jo Yong Kim) (검색결과 5 건)
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김조용 ( Jo Yong Kim ),이동원 ( Dong Won Lee ),정은선 ( Eun Sun Jung ),이교영 ( Kyo Young Lee ),조백기 ( Baik Kee Cho ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.6
Skin metastases from int:;rnal cancers are unusual; from a hepatoma they are extremely rare. The most common clinical presentation are solitary or multiple nodules that have appeared in one area of the body. Other forms include inflammatory and sclerodermoid metastatic growths. Case one was a 54-year-old male who had had partial hepatectomy of the right lobe of his liver following diagnosis of hepatocellular carcinoma five years ago. He presented with a 10 month history of a solitary nodule on the chin. Another case was a 46-year-old male, who had developed hepatocellular carcinoma forming a large subcutaneous mass by hemat,ogenous metastasis of the left zygomatic bone, masseter muscle and subcutaneous fat. Additional metastases were observed in the portal vein and multiple bones including the right shoulder, the 1st, 2nd, 3rd sacral spine and the right 3rd, 7t,h rib. In view of the clinical and histopathologic findings both skin tumors were considered to originate from the liver. The skin metastases may be indicative of progression by the primary tumor and also the first indication that a malignant tumor has not been eradicated. (Kor J Dermatol 1998;34(6): 1034-1038)
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건선 치료에 Calcipotriol연고와 Desoxymethasone연고의 비교연구 - 임상효과 및 면역조직화학적 변화 -
김조용(Jo Yong Kim),유영호(Young Ho You),김태윤(Tae Yoon Kim),김정원(Chung Won Kim) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.6
Backymad : Calcipotriol, topical vitamin D analogue, has been lemonstrated to have an effect for the treatment of psorsis with good tolerability. It is required to have comparative studies with the other topical agents whieh are widely used for the treatment of psoriasis. Objsctlve : Our purpose ia to compare calcipotriol with desoxmthasone ointment in their therapeutic efficacy and ability to affect dermal inflammatory cellular even. Methods : This study was a randomized, double blind, right/ ef comparison over 8 weeks in 10 patients. The ointments were applied twice daily to the lesion of psoriasis. Clinical efficacy, as measured by the Psoriasia Area and Severity Index(PASI) was assessed at 2, 4, 6 and 8 weeks after starting the treatments. The changes in the numbers of cernal immunocytes were assessed on frozen and paraffin-embedded sections by using immunobist chemicai stain methods before and after the treatments. Results : Reduction of PASI was statistically significant at all tine points for both of the treatments (P<0.01) but there was no significant defference betwee it be two treatinent modalities. At the completion of 8 weeks of treatments, the mean PASI reduction was 65 percents and 67 percents for calcipotriol and desoxymethasone ointments. On immunohistochemical staining, the numbers of LCA and HLA-DR positive cells were decreased significantly(P<0.05), and IL-2R and CD4 positive cells were not significaltly reduced in ach group after the treatment. Conclusoin : Calcipotriol orntment was as effective as desoxymethasone ointment, judged by the PASI and the dermal inflaixmatory cellular events on immunolhistchemical staining. (Kor J Dermatol 1994; 32(6): 1054-1063)
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권오찬 ( Oh Chan Kwon ),김조용 ( Jo Yong Kim ),박철종 ( Chul Jong Park ),오정 ( Jung Oh ),김형옥 ( Hyung Ok Kim ),김정원 ( Chung Won Kim ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.1
Sporotrichosis is a chronic infection that follows accidental implantation of the fungus Sporothrix schenckii into the skin. The infection begins with skin trauma under conditions when conidia may be present. A 48-year-old woman presented with a 5-year history of an 8X 12 cm sized, centrally depressed, erythematous plaque on the left wrist. She had been treated with antifungal agents at an other hospital for about 6 months but there was no improvement. The histopathological findings showed an infiltration of mononuclear cells and tuberculoid structures on the whole dermis and subcutis. According to the histopathological findings and clinical manifestations, she was diagnosed as having lupus vulgaris. There was much improvement of the lesion after antituberculous therapy. However, 2 months later she developed asymptomatic multiple erythematous papules around the lesion of lupus vulgaris and along the lymphatic drainage of the left arm. The histopathological findings of the newly developed lesion showed a granulomatous reaction and an infiltrate of acute and chronic inflammatory cells. Moist and creamy colonies were changed into brown-to-black ones with a leathery appearance with age. This appearance and clinical manifestations confirmed the diagnosis of lymphocutaneous sporotrichosis. This clinical appearance reflects that the sporotrichosis developed on the ulcerative lesion or biopsy site of lupus vulgaris. (Korean J Dermatol 1998;36(1): 181-185)
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박철종(Chul Jong Park),김조용(Jo Yong Kim),이종육(Jong Yuk Yi),김태윤(Tae Yoon Kim),김정원(Chung Won Kim),김동재(Dong Jae Kim) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.1
Backgound : Epidermal growth factor(EGF), a potent stimuant of epithelialization, has been noted to increase the thickness of the epidermis, increase the epithelial cell proliferartion and keratinization, and accelerate wound contraction. Objective : Our purpose was to evaluate the efficacy of topic 1 application of recombinant human epidermal growth factor(rhEGF) in the healing of full-theckness excision and burn wound. Methods : Full-thickness excision and burn wound were male in the back of the male Wistar rat. Recombinant human epidermal growth factor was apolied twice a day and the size of the wound was measured with planimetry every other day for 21 days. The keratinocytes of the circumcised foreskir were cultured in different concentrations of recombinant human epidermal growth factor and proliferation of the keratinocytes was evaluated. Results : 1. Regardless of wound types or base types, wound heal in the experimental groups (rhEGF 10, 30, 50 g/g) was generally better than that in the control or vehicle group. 2. The duration of wound healing was decreased as followa in order, in full-thickness excision wound, rhEGF 50 g/g, group, rhEGF 30 g/g group, rhEGF 10 g/g group, vehicle group, and control group and in full-thickness burn wound, rhEGF 30 g/g group, rhEGF 50g/g group, rhEGF 10g/g group, vehicb group, and control group. 3. In the biopsy specimen taken from the wound at 9th and 13th day, neodermis, neovascularization, the thicknesa and maturation of the collagen bundes and reepithelialization were more increased in the experimental groups than in the control or vehicle group. 4. In vitro culture of epidermal cells showed similar proheration in the concentration of rhEGF higher than 10 ng/rnl. Conclusion . These findings suggest that topical application of ecombinant humanepidermal growth factor is effective in the healing of full-thickness exoision and burn wound.(Kor J Dermatol 1995; 33(1): 76-84)
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