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김수억,서성훈,문기주 한국약제학회 1989 Journal of Pharmaceutical Investigation Vol.19 No.3
Coprecipitates of chlorpropamide (CPA)-sodium deoxycholate (DC-Na) were prepared at various ratios of CPA to the DC-Na. The X-ray diffraction and DSC measurements indicated that CPA in 1:1 and 1:3 w/w CPA-DC-Na coprecipitates did not exist in amorphous form, but the others were amorphous. The dissolution rate of CPA from the CPA-DC-Na coprecipitates increased in distilled water and KP V 2nd disintegration test fluid (pH 6.8), but decreased extremely in KP V 1 st disintegration test fluid (pH 1.2). The dissolution rates of CPA-DC-Na coprecipitates were compared with those of CPA alone and CPA-DC-Na physical mixtures. Especially, it was found that the dissolution rate of CPA markedly increased in the case of 1:5 CPA-DC-Na coprecipitate. The concentration of CPA dissolved from CPA-DC-Na coprecipitate reached a plateau within 5-10 min, and thereafter gradually decreased, indicating that CPA released from the coprecipitate was recrystallized.
정제류의 제제학적 연구 : 경도, 마손도, 붕해시간 및 변동계수에 대하여
김수억,서성훈,이현우 한국약제학회 1972 Journal of Pharmaceutical Investigation Vol.2 No.2
In order to know Hardness, Friability, Disintegration time and Coefficient of variance of the pharmaceutical tablets the 135 tablets sampled from market were tested in the paper. The samples tested in this paper were as follows; Antipyretics and Analgetics 41 Stomach and Digestives 22 Antituberculars 19 Vitamins 12 Sulfa drugs 9 Others (Antihistaminics etc) 32 Total 135 The results of the investigation are shown in table 1-8, Fig 1-Fig 6. Mean values of Hardness, Friability, Disintegration time and Coefficient of variance in each pharmaceutical preparation are as follows. <도표> The following summeries might be shown; 1. Ranges of Hardness, Friability, Disintegration time and Coefficient of variance are respectively 1.6 to 5.38 ㎏, 0.37 to 0.82 %, 2 minut 19 second to 5 minut 28 second and 2.09 to 3.10%. 2. According to the results, it could be indicated that higher Hardness shows lower Friability. 3. Against the general conception between Hardness and Disintegration time, higher Hardness shows lower Disintegration time. 4. It seems that higher mean weight shows lower Coefficient variance.
김수억,서성훈,박태암 한국약제학회 1989 Journal of Pharmaceutical Investigation Vol.19 No.1
Coprecipitates of ibuprofen (IPF)-sodium deoxycholate (DC-Na) were prepared at various mixing ratios of IPF to DC-Na. X-ray diffraction measurments indicated that IPF in 1:3 and 1:5 IPFDC-Na coprecipitate did not exist in the crystal form, however in the 1:8 coprecipitate, IPF remained its crystalline form. The dissolution rate was tested in pH 7.4 phosphate buffer by the paddle method of dissolution test of KP V. The dissolution rates of IPF from 1:1, 1:3, 1:5, 1:8 and 1:10 (w/w)IPF-DC-Na coprecipitates and physical mixtures were compared with that of IPF alone. It was found that the dissolution rate of 1:5 (w/w) coprecipitate was greater than that of pure IPF, coprecipitate and physical mixture at any other ratios of the two components. The concentration of IPF released from the IPF-DC-Na coprecipitates reached a plateau within 10 min, and thereafter gradually decreased indicating that IPF released from the coprecipitate was recrystallized due to the transient supersaturation.
김수억,서성훈,윤형중,백운봉 한국약제학회 1990 Journal of Pharmaceutical Investigation Vol.20 No.3
To increase the solubility of fentiazac which is used widely as a non-steroidal antiinflammatory drug, its inclusion complex and suppositories were prepared and studied. Inclusion complexes of fentiazac with β-cyclodextrin (β-CyD) were prepared by four diffrent methods; coprecipitation method, kneading method, solvent evaporation method, freeze drying method. Suppositories of fentiazac/β-CyD with PEG 1500 and Witepsol H-15 were prepared by solvent evaporation method and freeze drying method. Inclusion complex formation of fentiazac with β-CyD was ascertained by powder X-ray diffractometry, differential scanning calorimetry and IR spectroscopy. The dissolution rate of fentiazac from the inclusion complex increased in distilled water and KP 2nd disintegration test fluids (pH 6.8) but extemly decreased in KP 1st disintegration test fluid (pH 1.2). Inclusion complexes prepared by freeze drying method and solvent evaporation method were similar. Freeze drying method seemed to be suitable for preparation of complex with most higher dissolution rate but coprecipitation method seemed not to be suitable. The dissolution rate of fentiazac increased markedly by β-CyD complexation. The release rates of suppositories increased in the following order. Complex prepared by freeze dying method in PEG 1500>complex prepared by solvent evaporation method in PEG 1500>fentiazac in PEG 1500 > complex prepared by freeze dying method in Witepsol H-15 > complex prepared by solvent evaporation method in Witepsol H-15>fentiazac in Witepsol H-15.
김수억,서성훈,김지호 한국약제학회 1991 Journal of Pharmaceutical Investigation Vol.21 No.1
The purpose of this study was for the enhancement of dissolution rate of ketoprofen. The solid dispersions composed of ketoprofen(KP) and polyethylene glycol(PEG) 4000 or 6000 were prepared by fusion method at various ratios of KP to PEG (0.5 : 10, 1 : 10, 2 : 10, 3 : 10 and 4 : 10(w/w) and their physical mixtures were also prepared at the above ratios. Dissolution tests, X-ray diffraction study and differential scanning calorimetry study were carried out. It was found that the dissolution rates of solid dispersion and physical mixture at any ratio of the two components discribed above were greater than that of the pure ketoprofen. X-ray diffraction studies of ketoprefen suggested that less than 1 to 10 ratio of ketoprofen to PEG4000 (or 6000) was required to dispersion amorphous state in the carrier. In addition, the studies of DSC showed that ketoprofen had a sharp endothermic peak at 94℃ but not for the solid dispersion at the same temperature.
김수억,이현종,서성훈 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.4
Inclusion complex of sulfamethoxazole with β-cyclodextrin was prepared by freeze-drying method in molar ratios of 1:1, 1:1.25, 1:1.5 and 1:1.75, and the complex formation was identified by ultraviolet and infrared spectroscopies, powder X-ray diffractometry and differential scanning calorimetry. Dissolution rate and solid state stability of the complex were investigated in comparison with those of sulfamethoxazole powder and the physical mixture of sulfamethoxazole with β-cyclodextrin. As a result, the dissolution rate and the stability of solid complexes in various relative humidity conditions increased more remarkably than those of sulfamethoxazole powder and physical mixture. But the difference according to molar ratio of the complex was not recognized.