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누드마우스에 이종이식된 구강편평상피세포암종에 대한 thalidomide의 항암효과와 혈관형성억제에 관한 연구
김수곤,명훈,김명진,Kim, Su-Gon,Myoung, Hoon,Kim, Myung-Jin 대한구강악안면외과학회 2001 대한구강악안면외과학회지 Vol.27 No.4
Angiogenesis is an essential process for the growth, invasion and metastasis of cancer. However, it is uncertain that antiangiogenic effects can be a major treatment strategy of oral cancer. The aim of this study was to investigate whether thalidomide, which is known to be a potent inhibitor of angiogenesis, have inhibitory effect on the growth and antiangiogenic effects of oral squamous cell carcinoma(OSCC) xenografted in nude mice and whether antiangiogenesis of thalidomide can be included as a major treatment strategy of oral cancer. After human oral squamous cell carcinoma strain KB was subcutaneously implanted in 20 nude mice, the volume of tumor was measured every three days. When the tumor mass reached $75{\sim}100mm^3$, thalidomide(200mg/kg/d) was administered into 10 experimental nude mice and the same volume of distilled water was administered into 10 control nude mice and the tumor volume was measured every three days. The excised tumor masses on the 30th day after administration were frozen and processed for immunohistochemistry using vascular endothelial growth factor(VEGF) and CD31. We evaluated microvessel density and VEGF expression. The results were as follows ; 1. Thalidomide retarded the growth of human OSCC as compared with the control group, but it was not statistically significant. 2. A statistically significant lower microvessel density was observed in the thalidomide-treated group than in the control group(p<0.01) and thalidomide significantly reduced VEGF expression (p<0.01). Thalidomide exhibited significantly antiangiogenic effect, but did not inhibit the growth of human OSCC effectively. Antiangiogenic therapy of thalidomide alone is not likely to be effective in the treatment of human OSCC, but might be regarded as adjuvant chemotherapeutic strategy.
김수곤(Su Gon Kim),남상욱(Sang Ook Nam),김영미(Young Mi Kim),연규민(Gyu Min Yeon),이윤진(Yun-Jin Lee) 대한소아신경학회 2013 대한소아신경학회지 Vol.21 No.3
목 적 : 급성 뇌수막염으로 진단된 소아들에서 초기 및 입원 중 저나트륨혈증의 유병률 및 뇌수막염의 다양한 병인이 저나트륨혈증 발생에 미치는 영향을 조사하고, 임상 양상과 치료 과정들 중에 저나트륨혈증의 위험 인자를 파악하고자 하였다. 방 법: 2011년부터 2012년까지 부산대학교 어린이병원에서 급성 뇌수막염으로 치료받은 소아들을 대상으로 후향적으로 시행하였다. 뇌수막염의 병인에 따라 다음 4개 군으로 분류하였다: A군-무균수막염, B군-바이러스 뇌염/수막뇌염, C군-세균수막염, D군-결핵수막염. 입원 치료 중에 최소 2회 이상 혈청나트륨 농도를 평가하였고 135 mEq/L 미만 저하된 경우를 저나트륨혈증으로 정의하였다. 0.45% 식염수 미만 혹은 이상 농도의 수액을 맞은 환자들을 각각 F1군과 F2군으로 구분하였다. 결 과:전체 244명(A군: 185명, B군: 33명, C군: 23명, D군: 3명) 중, 55명(22.5%)에서 저나트륨혈증이 발생하였고, 이들 중 내원 초기의 저나트륨혈증(IH)이 32명, 입원 중 저나트륨혈증이 23명이었다. 초기 발생은 C군(7/23, 30.4%, P=0.010)이 A군(17/185, 9.2%, P=0.001), 혹은 B군(7/33, 21.2%, P=0.138)에 비해 의미있게 많았다. 입원 중 발생은 B군(9/33, 27.3%, P˂0.001)과 D군(2/3, 66.7%, P=0.001)이 A군(9/185, 4.9%, P˂0.001) 혹은 C군(3/23, 13.0%, P=0.533)에 비해 유의하게 높았다. 또한 F1군이 F2군에 비해 초기(25.0% vs. 11.6%, P=0.047) 및 입원 중(28.6% vs. 6.9%, P˂0.001) 저나트륨혈증 빈도가 모두 의미있게 높았다. 결 론 : 급성 뇌수막염의 소아들에서 저나트륨혈증이 드물지 않게 발생하였다. 병인에 따른 발생 빈도의 차이가 있으며, 특히 저장성 수액을 피하는 것이 저나트륨혈증 발생을 감소시키는데 도움이 될 것으로 사료된다. Purpose : To compare the effect of different etiologies in children with central nervous system (CNS) infections on the incidence of initial and hospital-acquired hyponatremia (IH and HAH) (plasma sodium concentration, PNa ˂135 mEq/L). Methods : Children with CNS infections during the period between 2011 and 2012 were evaluated retrospectively. Patients were classified into 4 groups: group A, aseptic meningitis; group B, viral meningoencephalitis; group C, bacterial meningitis; group D, tuberculous meningitis. All patients had measured the initial PNa and were retested serially. By the sodium concentration of IV fluid, children were divided into 2 groups: group-I of ˂0.45% saline in dextrose, and group-II of ≥0.45% saline in dextrose. Results : Of 244 children with CNS infections (group A: 185, group B: 33, group C: 23, and group D: 3), 55 patients (22.5%) revealed IH- or HAH-hyponatremia. IH and HAH was found in 13.1% (32/244) and 9.4% (23/244), respectively. The incidence of IH was significantly higher in group-C (30.4%, P=0.010) than in group-A (9.2%) or group-B (21.2%). HAH was more frequent in group-B (27.3%, P˂0.001) and in group-D (66.7%, P=0.001) than in group-A (4.9%) or in group-C (13.0%). Of the patients in group-I, 28.6% (8/28) developed more common HAH compared with 6.9% (15/216) of children in group-II (P˂0.001). Conclusion : IH and HAH were relatively common in children with CNS infections and their incidences were distinctly different among patients from different etiologies. It seems that the administration of hypertonic saline can help to reduce the incidence of HAH among children with CNS infections. election