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김금영(Keum-Yeung Kim),문경수(Kyung-Su Mun),전병준(Byung-Joon Chun),박용권(Yong-Kwon Park),김상구(Sang-Gu Kim),김영훈(Young-Hun Kim),김영길(Young-Kil Kim),이광식(Kwang-Sik Lee) 한국조명·전기설비학회 1999 한국조명·전기설비학회 학술대회논문집 Vol.1999 No.-
In this paper, multi gap type ozonizer(MGO) has been designed and manufactured. The ozonizer is equipped with three electrodes(central electrode of screw shape, internal electrode and external electrode) of cylinder shape. This paper describes the following two characteristics: ① The characteristics of discharge with variation of output voltage of AC H.V source, flux of oxygen supplied gas and discharge voltage. ② The characteristics of ozone generation by varying flux and discharge power.
TNBS로 유발된 마우스 대장염모델에서 설파살라진, 육계와 시호 복합 추출물의 항염증 및 세포 자멸 개선효과
김경조 ( Kyeong Jo Kim ),신미래 ( Mi-rae Shin ),김수현 ( Soo Hyun Kim ),김수지 ( Su Ji Kim ),이아름 ( Ah Reum Lee ),권오준 ( O Jun Kwon ),길기정 ( Ki-jung Kil ),노성수 ( Seong-soo Roh ) 한국응용생명화학회(구 한국농화학회) 2017 Journal of Applied Biological Chemistry (J. Appl. Vol.60 No.3
염증성 장 질환에 일반적으로 사용되는 설파살라진은 고용량 및 장기 섭취 후 다양한 부작용이 있다. 본 연구에서는 TNBS로 유발된 마우스 대장염 모델에서 설파살라진, 육계와 시호 복합추출물의 항염증 및 세포 자멸 개선효과를 확인하고자 하였다. 실험은 정상군, TNBS 대조군, Sulfasalazine (30 mg/kg)군, Sulfasalazine (60 mg/kg)군, Sulfasalazine (30 mg/kg)+육계 및 시호 혼합 (30 mg/kg)군, 총 5개의 군으로 나누었으며, 7일간 경구투여 하였다. 염증 및 세포 자멸 단백질은 western blot을 통해 발현량을 확인하였다. SCB 투여는 염증 단백질 및 세포 자멸과 관련된 단백질의 억제에 유의한 효과를 나타냈다. 이러한 결과로 보아 설파살라진, 육계와 시호 복합 추출물은 염증과 세포 자멸의 억제를 통해 염증성 장 질환을 개선시킬 수 있으며, 염증성 장 질환의 치료 대안 가능 물질로 사료되는 바이다. Inflammatory bowel disease (IBD) is including Crohn`s disease and ulcerative colitis. Sulfasalazine commonly used in IBD, possibly has various side effects after high dosage and long term intake. The present study aimed to investigate the sulfasalazine and combination with herbal medicine on 2,4,6- trinitrobenzene sulfonic acid (TNBS)-induced in mice model. TNBS-induced mice were injected through a flexible catheter 4 cm in length 1.6 mg TNBS. Animals were divided into five groups (n=12): Normal group, TNBS control group, Sulfasalazine (30 mg/kg) group, Sulfasalazine (60 mg/kg) group, Sulfasalazine (30 mg/kg)+Cinnamomi cortex and Bupleuri radix mixture (30 mg/kg) (SCB) group. Administration groups were fed extract during 7 days. The inflammatory, and apoptotic protein levels were determined using western blotting. SCB treatment showed an outstanding effectiveness in counteracting the IBD, as assessed by reduction of body weight loss, down-regulation of proinflammatory proteins and cytokines, and by inhibition of proteins related to apoptosis. This is the first report that sulfasalazine and Cinnamomi cortex plus Bupleuri radix mixture improve the severity of experimental IBD through the inhibition of both inflammation and apoptosis. We confirm that the SCB treatment instead of sulfasalazine alone may be promising as an alternative therapeutic plan against IBD, without any evidence of adverse effects.
2차 델타 시그마 변조기법을 이용한 고 정밀 및 고 안정 디지털 전자석 전원 장치에 관한 연구
김금수(Kum-Su Kim),장길진(Kil-Jin Jang),김동희(Dong-Hee Kim) 한국조명·전기설비학회 2015 조명·전기설비학회논문지 Vol.29 No.3
This paper is writing about developing magnet power supply. It is very important for power supply to obtain output current in high precision and high stability. As a switching noise and a power noise are the cause of disrupting the stability of output current, to remove these at the front end, low pass filter with 300Hz cutoff frequency is designed and placed. And also to minimize switching noise of the current into magnet and to stop abrupt fluctuations, output filter should be designed, when doing this, we design it by considering load has high value inductance. As power supply demands the stability of less than 5ppm, high precision 24bit(300nV/bit) analog digital converter is needed. As resolving power of 24bit(300nV/bit) analog digital converter is high, it is also very important to design the input stage of analog digital converter. To remove input noise, 4th order low pass filter is composed. Due to the limitation of clock, to minimize quantization error between 15bit DPWM and output of ADC having 24bit resolving power, ∑-? modulation is used and bit contracted DPWM is constituted. And before implementing, to maximize efficiency, simulink is used.
김형진(Hyeung Jin Kim),배상운(S. W. Pae),김대중(Dae Jung Kim),김수경(Soo Kyung Kim),김세화(Se Hwa Kim),이유미(Yu Mie Rhee),정상수(Sang Su Chung),안철우(Chul Woo Ahn),차봉수(Bong Soo Cha),송영득(Young Duk Song),임승길(Sung Kil Lim),김경 대한내과학회 2002 대한내과학회지 Vol.63 No.1
N/A Background: High sensitivity C-reactive protein (hsCRP) is more sensitive than standard CRP assay for evaluation of risk of coronary heart diseases and other atherosclerotic events. But, there were no data of association of serum hsCRP with risk factors of cardiovascular diseases and nonalcoholic fatty liver in Korean type 2 diabetic and nondiabetic subjects. Methods: A hundred type 2 diabetic subjects (51 men and 49 women) from Severance Hospital and 200 nondiabetic subjects participating medical checkup in Health Promotion Center (105 men and 95 women) were recruited and subjects with acute illnesses and chronic inflammatory diseases such as upper respiratory infection, rheumatoid arthritis, osteoarthritis, or viral hepatitis were excluded. A standardized interview was conducted by trained personnel; detailed information was collected on medical history, dietary habits and lifestyle characteristics, including smoking, alcohol and physical activity. Body mass index (BMI) was computed and biochemical study were undergone using fasting blood. All subjects were done abdominal ultrasonography for evaluation of fatty liver. Serum hsCRP concentration was measured by Nephelometer AnalyzerⅡ (Behring Co.) and a lower detection limit of test was 0.18 mg/L. Results: There was no difference in sex, BMI, presence of fatty liver, concentration of total cholesterol, triglyceride, high density lipoprotein-cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and uric acid between diabetic and nondiabetic subjects. Age, total colesterol/HDL-C ratio, fasting blood glucose and incidence of hypertension were higher in diabetic than nondiabetic subjects, but a rate of smoking was higher in nondiabetic than diabetic subjects. The mean concentration of serum hsCRP was remarkably increased in type 2 diabetic subjects than nondiabetic subjects (1.34±1.87 vs 0.71±0.80 mg/L, p<0.05). After adjustment of different variables between both groups, there was significantly difference of the concentration of serum hsCRP (p<0.05). In nondiabetic subjects, by univariate analysis, there was a positive correlation between hsCRP and age (r=0.26, p<0.05), BMI (r=0.34, p<0.05), systolic blood pressure (r=0.21, p<0.05), diastolic blood pressure (r=0.16, p<0.05), triglyceride (r=0.27, p<0.05), total cholesterol/HDL-C ratio (r=0.22, p<0.05), uric acid (r=0.15, p<0.05) and a negative correlation between serum hsCRP and HDL-C (r=-0.16, p<0.05). Interestingly, subjects with fatty liver had shown increased serum hsCRP concentration than subjects without fatty liver (0.99±0.96 vs 0.58±0.69 mg/L, p<0.05). But there were no correlation of serum hsCRP with the history of smoking, sex, physical activity, fasting plasma glucose and presence of hypertension. After multiple regression analysis, only BMI and age were associated with serum hsCRP. In diabetic subjects, there were significant correlation of serum hsCRP with HDL-C and fasting plasma glucose, but other risk factors of cardiovascular diseases and fatty liver were not. When we compared serum hsCRP according to numbers of risk factors of cardiovascular diseases in nondiabetic subjects, group without risk factors had 0.41±0.55 mg/L, group with one risk factor had 0.48±0.40 mg/L, group with two risk factors had 0.75±0.88 mg/L, group with three risk factors had 1.08±0.87 mg/L and group with four risk factors had 1.55±1.21 mg/L. There was significant difference of serum hsCRP according to numbers of risk factors of cardiovascular diseases (p<0.05). Conclusion: Serum hsCRP is correlated with risk factors of cardiovascular diseases and may be useful tool for prediction of accelerated, atherosclerotic process in nondiabetic subjects. Although there is association of serum hsCRP with few risk factors of cardiovascular diseases, serum hsCRP is elevated in diabetic subjects. Therefore it is necessary to evaluate usefulness of serum hsCRP using carefully selected diabetic subjects. In addition, our study had show
습식방사공정을 이용한 나노-피브릴화 폴리아크릴로니트릴 섬유 제조 및 특성
김수봉(Su Bong Kim),박길영(Kil-Young Park),정용식(Yong Sik Chung),윤이나(Yi-na Yoon),임정남(Jung Nam Im) 한국생산제조학회 2011 한국생산제조시스템학회 학술발표대회 논문집 Vol.2011 No.4
In wet-lay technology, PAN fibders have been used to produce wound-dressing materials because the fibers are not adhere to the wound. Nano-fibrillated PAN fibers were prepared by wet-spinning of PAN and PVA blend solution in DMSO and by removing PVA with hot water. The phase separation in coagulation process led to nano-fibrillated PAN fibers. The resultant PAN fibers showed the diameter of 100 ~ 200 ㎚.