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구선희,Gu, Sun-Hee 한국정보처리학회 2002 정보처리학회논문지B Vol.9 No.3
ANOVA 검정에서 검정통계량은 단일 또는 이중 비중심F분포를 따르며 비중심F분포는 일반적인 선형 가설 검정에서 검정함수 계산에 적용되고 있다. 기존 비중심F분포의 함수 계산에 대한 연구로 여러 접근 방법이 제시되었지만, 하나의 정확한 함수값을 구하는데도 많은 시간이 소요되는 문제점이 발생되었다. 본 논문에서는 기존 함수 계산의 문제점을 해결하기 위하여 다층 퍼셉트론 네트워크로부터 역전파 학습 알고리즘을 적용하여 비중심F분포의 함수값을 구하는 방법을 제안하였다. 제안된 신경망에 의한 함수값과 기존 Patnaik이 제시한 분포식에 의한 함수값의 차이를 표와 그림을 통하여 비교하였으며, 정확성과 계산속도를 고려할 때 Patnaik의 함수식에 의한 방법보다 신경망을 이용한 방법이 효율적임을 알 수가 있다. The test statistic in ANOVA tests has a single or doubly noncentral F distribution and the noncentral F distribution is applied to the calculation of the power functions of tests of general linear hypotheses. Although various approximations of noncentral F distribution are suggested, they are troublesome to compute. In this paper, the calculation of noncentral F distribution is applied to the neural network theory, to solve the computation problem. The neural network consists of the multi-layer perceptron structure and learning process has the algorithm of the backpropagation. Using fables and figs, comparisons are made between the results obtained by neural network theory and the Patnaik's values. Regarding of accuracy and calculation, the results by neural network are efficient than the Patnaik's values.
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구선희 동북아역사재단 2011 東北亞歷史論叢 Vol.- No.32
Existing research has elucidated that the changes in King Kojong ’s perception of the foreign world formed the background of the proclamation of the King’s direct rule and his open-door policy. Moreover, the research describes the King’s changing perception as a unilinear change in which the King gave up the Sino-centric perception of the world and accepted the modern international laws of the West. However, over the course of 1870s, the King’s perception underwent a series of changes. Before the proclamation of his own direct rule, King Kojong learned a lot of information about the Sino-centric international situation, Qing Dynasty’s internal political situation, and the political movements of Japan and the West from his convoys in the Qing Dynasty. Though it is not easy to analyze the character of the King’s changing perception of the world specifically, if there were some changes, the King still would not ignore opinions from his court. The official foreign policy of the time was to keep the door closed against Japan and Western powers with the idea of Wijeongcheogsa (衛正斥邪, protecting the right, repelling evil). But King Kojong sufficiently used a subservient diplomatic policy on domestic issues. The King made use of the information acquired by this subservient diplomacy: the news that the Qing Emperor Tong zhi started direct governing was the basis of King Kojong’s proclamation of direct rule. Since the Emperor had significant authority, the news justified the King’s trial of direct rule. While Prince Daewon was being criticized for his oppressive politics, King Kojong tried to realize the moral excellence of Confucianism and to maintain the foreign policy of Wijeongcheogsa, which was respected even by Chinese people. So it is possible to say that the King still had the Sino-centric perception of the foreign world when he declared the beginning of direct rule. It was after the proclamation of King Kojong’s direct rule that the diplomatic policy against Japan changed. The king tried to secure his rule by removing Prince Daewon and his followers, who were in opposition to improving relations with Japan, relations which had been broken off because of a problem with a diplomatic document. Though King Kojong’s will to mend relations with Japan was weakened by Japan’s attempt to force the open-door policy, the King coped with Japan’s intimidation with an appeasement policy and he created the Kanghwa treaty with Japan. The fact that the King opened the door to Japan seems to signify that the Joseon Dynasty entered the order of modern international laws. Still, King Kojong’s perception of the foreign world was based on the Sino-centric idea and he was merely trying to mend relations with a neighboring country. It was after the Dumojin incident of 1878 and the succeeding negotiations with Japan that King Kojong actually comprehended the significance of foreign relations based on the modern international laws. The incident can be a good example which shows that Joseon was still responding to Japan with the old idea of a good-neighbor policy. The experience Kojong acquired from the incident and negotiations with Japan enabled him to understand the significance of a treaty, like the Kanghwa treaty, in the order of modern international laws. He realized that having a treaty with a foreign country means that any problems concerning the treaty should be solved by negotiations with the country. And, at the end of the 1870s, King Kojong felt the need to expand trade relations with foreign countries.
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형광 염색체 In Situ Suppression Hybridization의 임상적 응용에 관한 연구
구선희 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2
A method for chromosome specific staining and its use in clinical cytogenetics is evaluated. Non isotopic fluorescent in situ hybridization provides a fast method for detection of specific nucleic acid sequences. We have used the single color fluorescent in situ hybridization with a α-satellite probe, unique sequence, microdissected probe to investigate the feasibility of simultaneous assessment of numerical and structural chromosome aberrations. When we used the α-satellits probe, Under condition of low stringency, cross hybridization with other subpopulations of the alpohoid family occurs in the whole chromosome and numerous hybridization sites are detected over metaphase. But we could findout the 3 signals in interphase chromosome of Down syndrome we could detect the signals which have been suspicted a deletion point with the unique sequence probe. We could delineate the X-Y translocated region by a microdisscted Y probe. From the above results, it can be a novel method for detection of cytogenetic abnormalities in the clinical cytogenetic field.
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