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유기인제에 의한 뇌 손상에 있어서 흥분성 아미노산의 역할
김동식,이봉희,이영재,김소미,김대성,이경갑,조문제,고봉우,박은혜,방성현,진주연,주창완,류기증,박민경 한국농화학회 2001 Applied Biological Chemistry (Appl Biol Chem) Vol.44 No.3
This study investigated the role of excitatory amino acid systems in the initiation of organophosphate-induced seizures and brain damages in rats through quantitative in viva microdialysis. Microdialysates were collected from the hippocampus of rat brain, treated with diisopropylfluorophosphate (DFP; 2.67 ㎎/㎏, s.c.) alone, and/or atropine sulfate (15 ㎎/㎏, i.m.) and procyclidine (30 ㎎/㎏, i.m.). The protective effects of atropine, a muscarinic blacker, and/or procyclidine, a N-methyl-D-aspartate and cholinergic antagonist, against DFP were examined. DFP treatment increased the levels of aspartate (Asp) and glutamate (Glu) significantly in the hippocampal persuate with the induction of seizures. Treatment of procyclidine could effectively block the increase of Asp and Glu levels. Atropine treatment showed no significant anticonvulsive effects against DFP-induced seizures. The increases of Asp and Glu levels by DFP were also completely blocked through the combined treatment of atropine and procyclidine. Histopathological findings on the hippocampus confirmed the above results. More effective protection was observed through the treatments of procyclidine alone or of both procyclidine and atropine than atropine alone against DFP-induced brain damage. Procyclidine was shown to be effective in DFP-induced seizures.
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