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설폭사플로르 살충제 중독 이후 발생한 저독성 보고 1례
오재훈 ( Jaehoon Oh ),강형구 ( Hyunggoo Kang ),임태호 ( Tae Ho Lim ),이상현 ( Sanghyun Lee ),안치원 ( Chiwon Ahn ) 대한임상독성학회 2015 대한임상독성학회지 Vol.13 No.1
Sulfoxaflor is the first insecticide belonging to the sulfoximine class and is efficient against sap-feeding insects that are resistant to other insecticides. Sulfoxaflor acts as a neurotoxin to the central nervous system of insects compared with very low toxicity to mammalian. We report on a case of a 67-year-old male who ingested insecticide and received conservative treatment for mild metabolic acidosis and gastrointestinal symptoms.
응급실 손상환자 심층조사 자료를 이용한 2017-2018년 중독 환자의 분석
고지윤 ( Jiyoon Koh ),전우찬 ( Woochan Jeon ),강형구 ( Hyunggoo Kang ),김양원 ( Yang Weon Kim ),김현 ( Hyun Kim ),오범진 ( Bum Jin Oh ),이미진 ( Mi Jin Lee ),전병조 ( Byeong Jo Chun ),정성필 ( Sung Phil Chung ),김경환 ( Kyung Hwa 대한임상독성학회 2020 대한임상독성학회지 Vol.18 No.2
Purpose: The annual statistics for poisoning are reported based on the data from poison control centers in many advanced countries. In 2016 a study was conducted to analyze the 2016 Korea Poisoning status. This study was conducted to make a better annual report for poisoning statistics in Korea from a 2017-2018 national representative database. Methods: This study was a retrospective analysis of poisoning patients based on the data from an emergency department (ED) based injury in-depth surveillance project by the Korea Centers for Disease Control and Prevention in 2017-2018. Bite or sting injuries were not included. Results: A total of 17714 patients presented to 23 EDs because of poisoning. Adults above 20 years old age accounted for 84.6% of the population, while the proportion of intentional poisoning was 60.8%. The poisoning substance presented in the ED were therapeutic drugs (51.2%), gas (20.3%), pesticides (16.4%), and artificial substances (11.4%). Overall, 35% of patients were admitted for further treatment. The mortality was 2.4% (422 cases), and the most common fatal substances in order were carbon monoxide, other herbicides, and paraquat. Conclusion: This study showed the 2017-2018 status of poisoning in Korea. The prognosis is different from the cause of poisoning and the initial mental state of the patient. Therefore, appropriate methods for preventing poisoning and therapeutic plans in specific situations are needed.
2016년 응급실 손상환자 심층조사 자료를 이용한 중독 환자의 분석
정성필 ( Sung Phil Chung ),이미진 ( Mi Jin Lee ),강형구 ( Hyunggoo Kang ),오범진 ( Bum Jin Oh ),김김현 ( Hyun Kim ),김양원 ( Yang Weon Kim ),전병조 ( Byeong Jo Chun ),김경환 ( Kyung Hwan Kim ) 대한임상독성학회 2017 대한임상독성학회지 Vol.15 No.2
Purpose: Some advanced countries have reported annual statistics for poisoning based on data from poison control centers. This study was conducted to propose a baseline format and statistics of poisoning in Korea from a national representative database. Methods: This study was a retrospective analysis of poisoning patients based on data from an emergency department (ED) based injury in-depth surveillance project by the Korea Centers for Disease Control and Prevention in 2016. Bite or sting injuries were not included. Variables related to poisoning were summarized using a similar format as the National Poison Data System in the United States. Results: A total of 7,820 poisoning patients presented to 23 EDs. Adults ≥20 years accounted for 84% of the population, while the proportion of intentional poisoning was 59.4%. The most common poisoning substances were therapeutic drugs (45%), gas (21%), pesticides (15%), and artificial toxic substances (13%). Overall, 34.5% of patients were admitted for further treatment. The mortality was 3.2% (248 cases), and the most common causative substances were carbon monoxide, glyphosate, and paraquat, in order. Conclusion: This study showed the recent status of poisoning in Korea. However, a comprehensive poisoning registry based on poison control centers may be required to provide more accurate national statistics in the future.
착화탄 연소에 의한 가스 중독 환자에서 혈중 중금속 농도의 영향에 대한 예비연구
이상환 ( Sang Hwan Lee ),이준철 ( Juncheol Lee ),조용일 ( Yongil Cho ),고벽성 ( Byuk Sung Ko ),오재훈 ( Jaehoon Oh ),강형구 ( Hyunggoo Kang ) 대한임상독성학회 2021 대한임상독성학회지 Vol.19 No.2
Purpose: It is known that the most common cause of gas poisoning in Korea is suicide attempts by burning ignition coals. Ignition coals are made from waste wood, and studies have been reported that heavy metals are emitted when this coal is burned. However, there was no study on how much heavy metal poisoning occurs in the human body through this, so this study was planned to find out whether the concentration of heavy metals in the blood increased in patients exposed to ignition coal combustion. Methods: From April 2020 to April 2021, blood lead, mercury, and cadmium concentrations were investigated in carbon monoxide poisoning patients who visited one regional emergency medical center in Seoul, and their association with exposure time, source of poisoning, and rhabdomyolysis were investigated. Results: During the study period, a total of 136 carbon monoxide poisoning patients were tested for heavy metals, and 81 cases of poisoning by ignition coal were reported. When comparing poisoning caused by combustion of ignition coal and other substances, there was no difference in the concentrations of lead, mercury, and cadmium in the blood, and there was no difference in the number of patients above the reference range. However, the patients exposed to more than 5 hours of ignition coal gas exposure are more frequent than those in the group less than 5 hours in lead (51.4% vs. 23.9%, p=0.012). Conclusion: Compared to poisoning with other combustible substances, the blood concentration of lead, mercury, and cadmium does not increase further in patients with gas poisoning by ignition coal. However, prolonged exposure may result in elevated levels of lead.