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조희령 ( Hee Ryung Cho ),최천필 ( Chun Pill Choi ),강익준 ( Ik Joon Kang ),조태호 ( Tae Ho Cho ),허충림 ( Choong Rim Haw ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.8
Castleman`s disease, also known as angiofollicular lymphoid hyperplasia or giant lymph-node hyperplasia, is an unusual form of a lymphoproliferative disorder, and is divided clinically into a solitary and a multicentric form. The multicentric form of Castleman`s disease is almost always of the plasma cell type. This can coexist with Kaposi`s sarcoma in some cases. Kaposi`s sarcoma is a multicentric, proliferative, vascular tumor involving cutaneous and visceral tissue. Iatrogenically-developed, immunosuppression-associated Kaposi`s sarcoma is usually the result of immunosuppressive therapy. A 61-year-old man diagnosed as the plasma cell type of Castleman`s disease, who had been treated with prednisolone for 2 years, was referred to the department of dermatology with numerous skin lesions consisting of confluent, violaceous-colored papules and plaques on his palm and soles. Histologic examination of the cutaneous lesions showed consistency with Kaposi`s sarcoma. We report a rare case of Kaposi`s sarcoma associated with multicentric Castleman`s disease. (Korean J Dermatol 2006;44(8):976~979)