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RISS 인기검색어
- 검색키워드
- 저자 : 강석민(Suck Min Kang) (검색결과 3 건)
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비소세포성 폐암의 예후인자로서 Flow Cytometric Nuclear DNA Content 와 S - phase Fraction 의 의의
강석민(Suck Min Kang),김주항(Joo Hang Kim),김성규(Sung Kyu Kim),이원영(Won Young Lee),정경영(Kyong Young Jung),이이형(Yi Hyeong Lee) 대한내과학회 1997 대한내과학회지 Vol.52 No.4
N/A Objectives: In surgically treated non-small cell lung cancer, patients have a wide difference in prognosis even though they may be in the same stage. Therefore it is difficult to establish the prognosis for individual lung cancer patients. In this study, by using flow cytometric analysis of nuclear DNA content and S-phase fraction(SPF) of surgically treated non-small cell lung cancer patients, we proposed to establish other prognostic factors and their validity in comparison with the existing ones. Methods: Paraffin-embedded tissue specimens from 81 surgically treated patients, diagnosed with non-small cell lung cancer ranging from stage I to stage IIIa, were analyzed by flow cytometrically determined nulear DNA content and S-phase fraction. Cellular DNA content stained with propidium iodide was analyzed by flow cytometry: histograms with a coefficient of variation exceeding 8% were not used. Results: 1) DNA content analysis was carried out for 59 of 81 patients. Of the 59 patients who were investigated by flow cytometry, 45 (76.3%) of the tumors were DNA aneuploidy and 14 (23.7%) were DNA diploidy. The proportion of DNA aneuploidy tumors showed no significant difference between cell types or stage. 2) S-phase fraction was evaluated for 36 of 81 patients. Mean value of SPF was 19.2% (±12.62)%. The value of SPF had nothing to do with stage. 3) The proportion of the high SPF group (more than 10% of cell proliferation cycle) was 75% With advance staging, the proportion of the high SPF group increased. 4) Significant difference in the median survival time was observed between the low SPF group and the high SPF group (32 months in low SPF, 12 months in high SPF) (p<0.05). No significant difference in the median survival time was observed between the aneuploidy group and the diploidy group (19 months in aneuploidy, 34 months in diploidy). 5) Significant difference in the disease free median survival time was observed between the low SPF group and the high SPF group (5 months in low SPF, 19 months in high SPF) (p<0.05). No significant difference in the disease free median survival time was observed between the aneuploidy group and the diploidy group (12 months in aneuploidy, 34 months in diploidy). 6) Upon multivariate analysis, stage and high SPF (more than 10% of cell proliferation cycle) were significant prognostic factors in surgically treated non-small cell lung cancer patients. Conclusion: The TNM stage and high SPF were significant as prognostic factors in surgically treated non-small cell lung cancer patients. There- fore new treatment plan should be needed in the patients who have high SPF.
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경구적 췌관내시경 직시하 조직생검으로 확진된 주췌관내 점액산생 다발성 유두상선종
강석민(Suck Min Kang),송시영(Si Young Song),박승우(Seung Woo Park),정재복(Jae Bock Chung),강진경(Jin Kyung Kang),박인서(In Suh Park),박찬일(Chan Il Park) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.5
As one of the various causes of mucin-producing tumor of pancreas, villous adenoma(papillo- matosis) is exceedingly rare. Because abundant mucin impairs obtaining precise pancreatography, the tumor shows a superficial spread, and histologic diagnosis is seldom made preoperatively, pancreatoscopy is useful to visualize the intraductal extent and to diagnose histologically. There has been no report on the mucin-producing papillomatosis in Korea, and only one histologically diagnosed case by peroral pancreatoscopic biopsy has been reported throughout the world. We report a 58-year old male whose duodenoscopy revealed the characteristic findings of papilla and ERP showed a l.5 cm nodular mass at the pancreas head. Peroral pancreatoscopy using 4.1 mm choledochoscope revealed a papillary tumor in main pancreatic duct, and numerous tiny finger-like projections were also noted around the above lesion. Pancreatoscopic biopsy revealed villous adenoma with low grade dysplasia. As the patient refused the operation, endoscopic retrograde pancreatic drainage(plastic, 10 Fr, 7 cm) was performed (Korean J Gastroenterol 1995;27:602-610)
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기관지 천식환자에 있어 고장성 생리식염수 흡입을 이용한 유도객담 검사 - 검사법의 확립과 유도객담내 염증세포 관찰 -
강석민(Suck Min Kang),김철우(Chul Woo Kim),박중원(Joong Won Park),홍천수(Chun Soo Hong) 대한내과학회 1997 대한내과학회지 Vol.52 No.6
N/A Objectives: From asymptomatic asthmatic patients unable to produce sputum spontaneously, we performed a non-invasive method obtaining sputum via inhalation of ultrsonically nebulised hyperosmolar saline(3%) which provides a way to investigate airway inflammation, And we also evaluated the effectiveness of the ultrasonic nebulizer in these patients. Methods: 50 asymptomatic patients unable to produce sputum spontaneously inhaled a hyperosmolar saline via an Ultrasonic nebulizer to induce sputum. We examined the quality of the sputum, total cell counts and differential cell counts of eosinophil after sputum processing. Results: 1) The quality of the sputum was uninterpretable (12%); poor(16%); fair(34%); good(38%), repectively. The mean induction time of expectoration was about 10 minutes. 2) The most common complaint was of a salty taste(45 cases). The mean fa11 in peak expiratory flow rate during inhalation of saline was 4.0% and the fall more than 20% was observed in 5 cases. 3) The mean eosinophil percent in induced sputum was 38.5%, The mean value of the total IgE and total peripheral eosinophil count was 818.2 IU/ml, 401.2/mm³ respectively, 4) There were no relationships between the sputum eosinophil count(%) and both the total IgE and the PC20(r=0.13, r=0.18). There was also an insignificant correlation between the sputum eosinophil count(%) and the total peripheral eosinophil count(r=D.22). Conclusion: We find that there are many eosinophils within induced sputum via inhalation of ultrsonically nebu1ised hyperosmolar saline from asymptomatic asthmatic patients unable to produce sputum spontaneously, Therefore we suggest that an induced sputum study via inhalation of hyperosmolar saline is useful to determine a patient`s status of airway inflammation.
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