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RNA Therapy: Current Status and Future Potential
김영국 전남대학교 의과학연구소 2020 전남의대학술지 Vol.56 No.2
Recent studies identified diverse RNAs including noncoding RNAs and their various action mechanisms in the cells. These RNAs regulate a variety of cellular pathways and are therefore expected to be important targets for the treatment of human diseases. Along with their extensive functional studies, RNA-based therapeutic techniques have developed considerably in recent years. After years of research and various trial and error, antisense RNAs and small interfering RNAs-based drugs have been developed and are now being used in the clinic. In addition, active research is ongoing to develop drugs based on RNA aptamer and messenger RNA. Along with the development of these RNA-based drugs, diverse strategies have been developed to transport RNA drugs into the cells efficiently. RNA therapy has many advantages over existing small molecule or monoclonal antibody-based therapies, including its potential to target all genes in the cells. This review will introduce the history of RNA therapy, and explain the basic concepts of RNA therapy and RNA-based drugs on the market or clinical trials. In addition, the future potential of RNA therapy will be discussed.
김영국,송병관,이정구,백연경,Kim, Y.K.,Song, B.K.,Lee, J.G.,Baek, Y.K. 한국분말야금학회 2020 한국분말재료학회지 (KPMI) Vol.27 No.2
Fluorescent nanoparticles are characterized by their unique properties such as luminescence, optical transparency, and sensitivity to various chemical environments. For example, semiconductor nanocrystals (quantum dots), which are nanophosphors doped with transition metal or rare earth ions, can be classified as fluorescent nanoparticles. Tuning their optical and physico-chemical properties can be carried out by considering and taking advantage of nanoscale effects. For instance, quantum confinement causes a much higher fluorescence with nanoparticles than with their bulk counterparts. Recently, various types of fluorescent nanoparticles have been synthesized to extend their applications to other fields. In this study, State-of-the-art fluorescent nanoparticles are reviewed with emphasis on their analytical and anti-counterfeiting applications and synthesis processes. Moreover, the fundamental principles behind the exceptional properties of fluorescent nanoparticles are discussed.
김영국 한국교통연구원 2020 交通硏究 Vol.27 No.1
Higher traffic flows generally lead to increased direct pollutant emissions, resulting in higher pollution concentrations. In the case of ozone (O3), a secondary pollutant, however, decreased traffic flows during weekends create favorable conditions for generating O3. Similarly, urban background regions have better atmospheric circumstances for O3 creation than roadside areas. These two favorable temporal and spatial conditions result in higher O3 concentrations in urban regions. To explain these counterintuitive phenomena, I reviewed the chemistry of O3 and discussed the changes in traffic flows and solar radiation in Seoul, Korea. Solar radiation plays a vital role in determining O3 concentrations. The more ultraviolet (UV) radiation, the more O3 will be generated because solar radiation initiates the photo-dissociation of nitrogen dioxide (NO2). Dynamic O3 concentration is determined according to the O3 generation rate and the O3 destruction rate. UV rays play a crucial role in the production of O3, and the production ratio varies depending on the intensity of UV. Therefore, to explain hourly O3 concentrations, it is necessary to adopt a properly modified UV ray as an explanatory variable. The result shows that the 6-hour moving average of UV ray is identified to explain best for hourly O3 concentrations.
金永國 홍익대학교 영상애니메이션연구소 2003 디자인영상논문집 Vol.- No.3
Transmitting information of contemporary communication society has been changing tremendously beyond our imagination. We have got more used to acquire information actively through digital media than learn information passively by means of traditional printing media. Newspaper advertising need to be both visual expression effect for the moderns who avoid read newspaper and strong appeal function for the readers under the reality of advertising media. Recently, we have seen exceptional advertising using experimental typographic application instead of formal typographic advertising. It seems to suggest the device that increases lasting advertising effects applying typography character. As far as recent newspaper advertising, headline shows less important than visual image relatively. From reading newspaper to seeing newspaper in transitional period, the importance of appropriate experimental expressions in advertising headline is becoming influential with the reading basic function. It typography is important that as a view point of receiving information actively through experimental advertising headline not simply delivery information. Through using letters which are symbolic sign systems of language have to approach to the receivers with effective Information systems. In hence, seeking the organizational methods in information society expanding advertising range, it will be supposed to be efficient correspondent attitude.
Mg_2SiO_4 열형광체의 자외선 선량에 대한 열형광발광 특성
김영국 慶南大學校 附設 工業技術硏究所 2003 硏究論文集 Vol.21 No.1
Mg_2SiO_4 : Dy, Tb열형광체 소자를 가압, 가열하여 제작하였다. Mg_2SiO_4 : Dy, Tb 열광형체 소자의 열광이 가압, 가열온도와 가열시간에 따른 변화를 통해 최적 파라미터들을 결정하였다. Mg_2SiO_4 : Dy, Tb열형광 선량계의 글로우 곡선의 주 피크는 UV에너지와 미립알갱이들의 결정 크기에 비례함을 알 수 있었다. 자외선 조사시간의 증가에 따라서 열자극 발광의 강도는 증가하였고, TL 글로우 곡선의 주 peak는 낮은 온도 쪽으로 이동하였다. Mg_2SiO_4 : Dy, Tb pellets were made by using a sintering process, including pressing and heat treatment. In the present study, the optimum parameters of the sintering for the Mg_2SiO_4 : Dy, Tb pellets obtained such as the pressing pressure, the sintering temperature and the sinter ing time were in terms of thermoluminescence. Experimental results showed that the main peak of the glow curve for Mg_2SiO_4 : Dy, Tb thermoluminescence dosimeter was clearly correlated with the energy of the UV and with the grain size. The intensity of the TL glow curve increased and its main peak position shifted to lower temperature with increasing UV irradiation time.