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A Case of Giant Colonic Muco-submucosal Elongated Polyps Associated with Intussusception
김주헌,이승윤,장제호,한현영,강동욱 대한병리학회 2016 Journal of Pathology and Translational Medicine Vol.50 No.6
Colonic muco-submucosal elongated polyp (CMSEP), a newly categorized non-neoplastic colorectal polyp, is a pedunculated and elongated polyp composed of normal mucosal and submucosal layers without any proper muscle layer. We herein report a giant variant of CMSEP associated with intussusception in the rectosigmoid colon, with a review of the literature. A 48-yearold woman underwent a laparoscopic low anterior resection due to multiple large submucosal polypoid masses associated with intussusception. Grossly, the colonic masses were multiple pedunculated polyps with a long stalk and branches ranging in size from a few millimeters to 14.0 cm in length. Microscopically, there was no evidence of hyperplasia, atypia, or active inflammation in the mucosa. The submucosal layers were composed of edematous and fibrotic stroma with fat tissue, dilated vessels, and lymphoid follicles.
김주헌,이승윤,박미자,이혜경,손현진,김창남,강동욱 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.1
Background: Thymosin β4 is a multi-functional hormone-like polypeptide, being involved in cell migration, angiogenesis, and tumor metastasis. This study was undertaken to clarify the clinicopathologic implications of thymosin β4 expression in human colorectal cancers (CRCs). Methods: We investigated tissue sections from 143 patients with CRC by immunohistochemistry. In addition, we evaluated the expression patterns and the clinico-pathological significance of thymosin β4 expression in association with hypoxia inducible factor-1α (HIF-1α) expression in the CRC series. Results: High expression of thymosin β4 was significantly correlated with lymphovascular invasion, invasion depth, regional lymph node metastasis, distant metastasis, and TNM stage. Patients with high expression of thymosin β4 showed poor recurrence-free survival (p = .001) and poor overall survival (p = .005) on multivariate analysis. We also found that thymosin β4 and HIF-1α were overexpressed and that thymosin β4 expression increased in parallel with HIF-1α expression in CRC. Conclusions: A high expression level of thymosin β4 indicates poor clinical outcomes and may be a useful prognostic factor in CRC. Thymosin β4 is functionally related with HIF-1α and may be a potentially valuable biomarker and possible therapeutic target for CRC.
김주헌 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
Se nanowires are one of the chalcogenide-based nanostructures that have attracted interest in various research fields of research because of their unique characteristics. Herein, we report on the fabrication of Se nanowires from bulk SnSe crystals throughby an organic acid- assisted chemical transformation process. During the reaction process, tThe concentration of the organic acid iwas found to be critical to control the morphology of the final products. Se nanowires with the diameter of ~40 nm diameter and length of ~1 μm length are obtained after the transformation, and we suggestThe reaction mechanism for the chemical transformation is proposed of SnSe. Moreover, Tthe effect of the Se nanoparticles in SnSe on theits thermoelectric behaviours in SnSe is also investigated and discussed. The Se nanowires and Se/SnSe composites reported in this study will open up new possibilities tofor various applications with excellent performances.
김창근,김주헌 중앙대학교 생산공학연구소 1999 생산공학연구소 논문집 Vol.8 No.2
고분자의 구조설계를 통해서 단상 혹은 이에 준 하는 상용성을 이루기 위해선 고분자간의 열역학적 정보가 필수적으로 요구된다. 본 연구에서는 블렌드를 구성하는 각 성분간의 열역학적 정보를 정성적 혹은 정량적으로 결정하고 이를 이용하여 단상의 블렌드를 제조하는 방법을 제시하고자 하였다. 이를 위하여 다양한 구조의 Polycarbonate 와 Pendent group을 달리한 여러 종류의 Polymethacrylate간의 상용성을 조사하였으며 이를 바탕으로 고분자 구조를 설계하여 단상의 블렌드를 제조하였다. 또한 단상의 블렌드에 포함된 각 고분자간의 상호작용에너지는 상분리온도(Phase boundary)와 상태방정식(Equation of State)을 이용하여 정량화 하였다. 이렇게 정량화되어진 상호작용에너지는 실험을 거치지 않고도 단상의 블렌드를 만드는 데 중요한 정보로 사용되어 질 수 있다. In order to improve miscibility of blends through a construction design, we certainly need thermodynamic information between polymer and polymer. in this work, we determine thermodynamic information of each component with quantity or quality. we can present the way that we produce miscible blends. for this work, we research miscibility between various construction of Polycarbonate(PC) and different pendent group ofvarious MA(methacrylate) system. we research miscibility between various construction of polycarbonate(PC) and different pendent group of various MA(methacrylate) system. we make miscible blends through design of polymer consruction. Interaction energy density of each polymers obtained by phase boundary and equation of state(EOS). finally through this work, phase behavior, which go on l phase or 2 phase preluded by interaction energy density which obtain this work when we make some blends.