http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
김선행,정래환,구병삼,Kim, Sun-Haeng,Jung, Rae-Hwan,Ku, Pyong-Sahm 대한생식의학회 1992 Clinical and Experimental Reproductive Medicine Vol.19 No.1
In vitro fertilization and embryo transfer (IVF & ET) is widely used for the males with subnormal or abnormal semen quality, as this was recommended in view of the relatively small numbers of spermatozoa required for fertilization and subsequent pregnancies could be obtained. The aim of this study is to know how the various functional parameters of spermatozoa in semen analysis affect the outcome IVF. This study was carried out between 1988-1989, with male factor patients selected on the basis of the semen quality. The selection criteria was based upon the mean values of concentration,% motility and % normal morphology from at least two semen analysis. There is a significant decrease in the fertilization and embryo transfer rates in the study group compared with control group (35.9% vs. 68% and 48.6% vs. 85.5% respectively), however, there was no significant difference in the pregnancy or delivery rates (19.6% vs. 21.4% and 60.0% vs. 62.5% respectively) per embryo transfer cycles. Fertilization rate is variously affected by the type and degree of sperm defect. No pregnancy was occurred in triple defect group and asthenoteratospermia group. There is no significant increase in the abortion rate in the male factor group. Improvement have to be made with the fertilization rate, as the pregnancy rate per OPU cycle in male factor group is still lower than that of normal group (9.5% vs. 18.3%). In conclusion, IVF can be used as a treatment for male factor infertility and the preparation of the semen sample can be modified to improve sperm recovery and obtain fertilization from abnormal semen samples.
체외수정시술을 위한 성선자극호르몬 과배란유도에 Poor Response를 나타낸 환자에서 GnRH Analogue의 사용
김선행,이희경,구병삼,Kim, Sun-Haeng,Lee, Hee-Kyung,Ku, Pyong-Sahm 대한생식의학회 1993 Clinical and Experimental Reproductive Medicine Vol.20 No.1
In 27 patients with the past history of poor response to the gonadotropin superovulation induction due to poor follicular growth or permature surge of endogenous luteinizing hormone, the effectiveness of pituitary supperssion with the gonadotropin releasing hormone agonist(GnRH-a) in in vitro fertilization(IVF) program was evaluated in 43 cycles using a combination regimen of D-Trp-6 LHRH(Decapeptyl, Ferring)and FSH/hMG from June, 1989 to August, 1990 at Korea University Hospital IVF Clinic. At midluteal phase of menstrual cycle, Decapeptyl-CR was administered by long-term protocol to minimize initial agonistic effect of endogenous gonadotropins. After the confirmation of pituitary suppression, about 2-3 weeks after GNRH-a administration, ovarian follicle growth was stimulated with FSH/hMG and followed by transvaginal ultrasonic measurement of follicle size and by monitoring of serm E2 and LH if necessary. When compared with the control group stimulated with gonadotropin regimen only, the cancellation rate and occurrence rate of premature LH surge during gonadotropin treatment were significantly lower in study group(11.6% and 2.4%, respectively). There is no significant differences in the mean number of aspirated oocytes, fertilization/cleavage rate, embryo transfer(ET) rate, and mean number of embryos transferred between the two groups. The pregnancy rate per treatment cycle, 16.3%, and per ET cycle, 23.3%, were significantly higher in the study group compared with those of control group. These data suggest that GnRH-a therapy is effective for previous poor responder In gonadotropin superovulation induction for IVF.
체외수정시술을 위한 성선자극호르몬 과배란유도에 Limited Ovarian Reserve를 갖는 환자에서 성장호르몬의 사용
김선행,장기훈,구병삼,Kim, Sun-Haeng,Chang, Ki-Hoon,Ku, Pyoung-Sahm 대한생식의학회 1994 Clinical and Experimental Reproductive Medicine Vol.21 No.3
Despite increasing success rate of IVF, poor response to ovarian stimulation remains a problem. So, attempts to improve ovarian responses, for example, by using combined gonadotropin-releasing hormone analogue(GnRH-a) and human menopausal gonadotropin(hMG) have shown limited success. It is reported that response of granulosa cells in vitro to FSH is stimulated by co-incubation with IGF-l, and IGF-l production can be increased by growth hormone. This suggest that combination regimen of G.H. and hMG may augment follicle recruitment. In fifteen patients who had previous history of poor ovarian response to gonadotropin stimulation after pituitary suppression with mid -luteal GnRH-a, the effectiveness of cotreatment with G.H. in IVF program was evaluated using a combination regimen of G.R. and hMG at Korea University Hospital IVF Clinic. Ovarian responses to gonadotropin stimulation in control and GH-treated cycles assessed by total dose and duration of hMG treatment, follicular development and peak $E_2$ level, number of eggs retrieved, and fertilization rates were also assessed. In each group, serum and follicular fluid IGF-1 concentrations on day of egg collection were measured by RIA after acidification and extraction by reveresed phase chromatography. Patients receiving G.H. required fewer days and ampules of gonadotropins, developed more oocytes, and more embryos transferred. But, the differences were not statistically significant, except the duration of hMG treatment. Our data showed a significantly higher concentration of IGF-l in the serum, not in the follicular fluid, of patients treated with G.H. compared with control group. These data suggest that growth hormone treatment does not improve the ovarian response in women with limited ovarian reserve to gonadotropin stimulation for IVF.
난포기초기 난포자극호르몬 (FSH) 과 난포호르몬 (E2) 의 체외수정시술 성공 예측인자로서의 역할에 관한 연구 할에 관한 연구
김선행,임옥룡 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.8
본연구는 난포기초기 난포자극 호르몬 치에 따른 과배란유도 약제에 대한 난소반응과 체외 수정시술의 예후를 파악하여 체외수정 시술시 예측 인자로서의 가능성을 알아보고 난포기초 기 난소자극호르몬과 기초 난포호르몬과의 상관관계를 파악하여 각각의 수치가 서로 유의한 관계가 있는지 규명하기 위하여 본 연구를 시행하여 다음과 같은 결론을 얻었다. 1. 난포 기초기 난포자극호르몬 치가 높은 군일수록 혈청 최고 난포호르몬(peak E2)치는 점차적으로 낮아지는 소견을 보이면 통계적으로 유의한 차이를 보였다. 2. 난포기초기 난포자극호르몬 치가 높은 군일수록 난자 채취당 임신율은 점차 감소된 소견 을 보이며 I 군과 III군에서 통계적으로 유의한 차이를 보였다. 3. 난포기초기 난포자극호르몬 치가 높은 군 일수록 주기취소율은 점차 증가되는 소견을 보 이며 통계적으로 유의한 차이를 보였다 4. 난포기초기 난포호르몬치와 난포기초기 난포자극호른몬 치는 통계적으로 유의한 관계가 없다. 이상과 같은 연구결과로 체외수정시술에 앞서 난포기초기 난포자극호르몬 수치를 측정하는 것이 체외수정시술 예후의 예측인자로 유용한 자료라고 사료된다. This study was to examine whether serum follicle-stimulating hormone and estradiol on day 3 of the cycle (D3 FSG and E2) can predict ovarian response and vitro fertilization(IVF) outcome. Data from 474 cycles in 276 patients for multiple follicle recruitment from January 1989 to December 1991 were analysed how basal follicle stimulation hormone level affect the outcome of in vitro fertilization(IVF) . We divided all the cycles into three groups according to basal follicle-stimulation hormone levels . The peak E2 values, the mean number of follicles aspirated , the mean number of oocytes retrieved, the mean number of oocytes fertillized, the mean number of embryos cleaved, the mean number of embryos transferred, and canacellation rate was different in the three groups. The pregnancy rate per OPU cycle was significantly higher in group I compared with group III, However no significant differences were noted in pregnancy rate per ET cycle among the three groups. Cycle day 3 FSH levels are predictive of pregnancy outcome and stimulation characteristics in IVF, and may be useful in counselling patients. There was no correlation of day 3 FSH levels and day 3 E2 levels.