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Identification of Homer1 as a Potential Prognostic Marker for Intrahepatic Cholangiocarcinoma
Wu, San-Yun,Yu, Ming-Xia,Li, Xiao-Gai,Xu, Shu-Fang,Shen, Ji,Sun, Zhen,Zhou, Xin,Chen, Xing-Zhen,Tu, Jian-Cheng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Background: The aim of the present study was to analyze whether Homer1 is a potential prognostic marker for intrahepatic cholangiocarcinoma (ICC). Materials and Methods: The expression of Homer1 in ICC tissue was detected with immunohistochemistry and levels of protein in ICC and paratumor tissues were evaluated by Western blotting. Survival analysis by the Kaplan-Meier method was performed to assess prognostic significance. Results: Homer1 expression was high in 67.4% (58/86) of ICC samples, and there was significant difference between ICC and adjacent noncancerous tissues (p<0.001); high expression was associated with poor histologic differentiation (p=0.019), TNM stage (p=0.014), lymph node metastasis (p=0.040), and lymphatic invasion (p=0.025). On Kaplan-Meier analysis, a comparison of survival curves of low versus high expressors of Homer1 revealed a highly significant difference in OS (p=0.001) and DFS (p=0.006), indicating that high expression of Homer1 was linked with a worse prognosis. Multivariate analyses showed that Homer1 expression was an independent risk factor predicting overall survival[Hazard ratio(HR), 7.52; 95% confidence interval (CI), 2.63-21.47; p=0.002] and disease-free survival (HR, 11.56; 95%CI, 5.17-25.96; p<0.001) in ICC. Conclusions: Homer1 promotes lymphatic invasion and associates with lymph node metastasis and poor prognosis of ICC. The current study shows that Homer1 may be an independent prognostic factor for ICC patients after curative resection, and it provides an important basis for screening/treating high-risk patients.
Genetic Analysis of Generalized S-Transform
Yun Lin,Xiaowan Yu,Chunguang Ma,Zheng Dou,Zhiqiang Wu,Zhiping Zhang 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.4
This text starts with the short time Fourier transform and continuous wavelet transform to deduce the generalized S-transformation. From the point of generation views, we analyzed a relative relationship between generalized S-transformation and the short time Fourier transform, and the other relative relationship between generalized S transform and continuous wavelet transform. The article gives the definition of “the gene mutation of formula” and “the genetic restructuring of formula”, and introduces the deriving process of the two core concept. Theoretical analyses show that generalized S-transformation inherited the desirable characteristics in short time Fourier transform which use the window function to select suitable signal. Through genome sequencing of specific parameters, generalized S-transformation has a stronger adaptation that the time-frequency window could make real-time adjusting of frequency. Moreover, generalized S-transformation breaks out limitation that the wavelet function has to content the admissible conditions. From the point of gene mutation, we give the definition of “the gene mutation of formula”. Based on the structure form of wavelet functions, we define the generalized S-transformation with a wider domain of definition. Generalized S-transformation inherited the desirable characteristics of the short time Fourier transform and continuous wavelet transform. It has great utility and flexibility in analyzing non-stationary signals.
Wu, Xiao-Feng,Song, Hai-Yan,Yoon, Jeong-Mo,Yu, Yeon-Tae,Chen, Yun-Fa American Chemical Society 2009 Langmuir Vol.25 No.11
<P>Core−shell Au@TiO<SUB>2</SUB> nanoparticles with truncated wedge-shaped TiO<SUB>2</SUB> morphology have been synthesized successfully by a simple and flexible hydrothermal route. Morphological evolution of TiO<SUB>2</SUB> shells was investigated by transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), and X-ray diffraction technique. It has been revealed that the truncated wedge-shaped TiO<SUB>2</SUB> shells experience an epitaxially segmented orientation growth. Also, the (101) crystal planes of TiO<SUB>2</SUB> crystals grow preferentially on the surface of gold nanocrystals stabilizing the heterointerfaces, then faster [001] growth results in the “budding” process occurs, producing growth sites on the initial deposition TiO<SUB>2</SUB> layers, where the TiO<SUB>2</SUB> crystals grow up into truncated wedge-shaped morphologies. It is also found that morphological evolution of TiO<SUB>2</SUB> shells is dependent on the produced F<SUP>−</SUP> ion concentration from hydrolyzed TiF<SUB>4</SUB> precursors. The produced F<SUP>−</SUP> ions not only facilitate the formation of well-defined wedge-like TiO<SUB>2</SUB> shells, but also contribute to the externally exposed truncated crystal {004} facets. As the representative photocatalyst, the catalytic activities of the resultant core−shell Au@TiO<SUB>2</SUB> nanoparticles were investigated by photoinitiated oxidation degradation of gaseous acetaldehyde. It has been indicated that the nanostructured core−shell Au@TiO<SUB>2</SUB> photocatalyst represents high photocatalytic activity when exposed to UV or visible light irradiation. The high phototocatalytic performance is also largely attributed to the preferentially grown TiO<SUB>2</SUB> shell structures and metal (Au)-TiO<SUB>2</SUB> heterointerfaces.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2009/langd5.2009.25.issue-11/la900035a/production/images/medium/la-2009-00035a_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/la900035a'>ACS Electronic Supporting Info</A></P>
Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy
Yu-Hsiang Hsu,Hsing-Hui Li,Junne-Ming Sung,Wei-Yu Chen,Ya-Chin Hou,Yun-Han Weng,Wei-Ting Lai,Chih-Hsing Wu,Ming-Shi Chang 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Interleukin (IL)-20, a proinflammatory cytokine of the IL-10 family, is involved in acute and chronic renal failure. The aim of this study was to elucidate the role of IL-20 during diabetic nephropathy development. We found that IL-20 and its receptor IL-20R1 were upregulated in the kidneys of mice and rats with STZ-induced diabetes. In vitro, IL-20 induced MMP-9, MCP-1, TGF-β1 and VEGF expression in podocytes. IL-20 was upregulated by hydrogen peroxide, high-dose glucose and TGF-β1. In addition, IL-20 induced apoptosis in podocytes by activating caspase-8. In STZ-induced early diabetic nephropathy, IL-20R1-deficient mice had lower blood glucose and serum BUN levels and a smaller glomerular area than did wild-type controls. Anti-IL-20 monoclonal antibody (7E) treatment reduced blood glucose and the glomerular area and improved renal functions in mice in the early stage of STZ-induced diabetic nephropathy. ELISA showed that the serum IL-20 level was higher in patients with diabetes mellitus than in healthy controls. The findings of this study suggest that IL-20 induces cell apoptosis of podocytes and plays a role in the pathogenesis of early diabetic nephropathy.
Thrust Ripples Suppression of Permanent Magnet Linear Synchronous Motor
Yu-wu Zhu,Yun-Hyun Cho IEEE 2007 IEEE transactions on magnetics Vol.43 No.6
<P>The thrust ripples in permanent magnet linear synchronous motor (PMLSM) are mainly generated by the distortion of the stator flux linkage distribution, reluctance force due to the relative position between the mover and stator, cogging force caused by the interaction between the permanent magnet (PM) and the iron core, and the end effects. This is the significant drawback which will deteriorate the performance of the drive system in high-precision applications. Comparing the complexity of the motor structure design to eliminate the thrust ripples, an optimal control method is more desirable. This paper focuses on thrust ripples reduction based on the predictive control algorithm. To minimize the thrust ripples and realize the high-precision control, the components of thrust ripples are extracted by finite element method (FEM) first and then compensated by injecting the instantaneous current to counteract the thrust ripples using the field-oriented control (FOC) method. The effectiveness of this proposed method is verified by the simulation using Simulink/Matlab according to the comparison between the compensation and noncompensation cases</P>
Control Based Reduction of Detent Force for Permanent Magnet Linear Synchronous Motor
Yu-wu Zhu(주옥오),Yun-hyun Cho(조윤현) 전력전자학회 2008 전력전자학술대회 논문집 Vol.- No.-
The detent force of the permanent magnet linear synchronous motor (PMLSM) is caused by the interaction between the permanent magnet and the iron core of the mover without input current. It is a function of the mover position relative to the stator. This paper proposes a control based method to reduce the detent force for the PMLSM. This detent force that can be predicted by finite element method (FEM) is compensated by injecting the instantaneous current using the field oriented control (FOC) method. Both the simulated and experimental results are reported to validate the effectiveness of this proposed method.
Yun-Chieh Tsai,Yu-Chen Lin,Chun-Chih Huang,Oliver B. Villaflores,Tzong-Yuan Wu,Shih-Ming Huang,Ting-Yu Chin 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.5
Aging and lifestyle factors, including high-sugar and high-fat diets, promote a systemic metabolic imbalance that promotes neurodegeneration. Hericium erinaceus has long been used in traditional Chinese medicine. Recently, its functional activities, such as antimetabolic dysfunction, antineuroinflammatory activities, and stimulation of nerve growth factor (NGF) synthesis, have been revealed. This study demonstrated that Hericium erinaceus mycelium (HEM) and an isolated diterpenoid derivative, erinacine A (EA), may reverse spatial learning disabilities in aging mice (15 months old) fed with a high-fat and high-sucrose diet (HFSD). Aging mice were randomly assigned to one of four treatment groups: (1) a chow diet (control), (2) an HFSD, and an HFSD supplemented with either (3) HEM or (4) EA for 18 weeks. The Morris water maze (MWM) and Y-maze were used for behavioral assessments. Both HEM- and EA-treated mice had shorter mean daily escape latencies than HFSD-treated mice in the MWM. In addition, HEM-treated mice had a slightly increased exploratory time and frequency in the novel arm in the Y-maze. Quantitative PCR revealed that both HEM- and EA-treated mice exhibited reduced messenger RNA (mRNA) expression of tumor necrosis factor-α, interleukin-1β, and HEM-treated mice exhibited increased mRNA expression of NGF and NeuN in the hippocampus. Moreover, HEM and EA also decreased body weight, abdominal fat, plasma glucose, serum and liver total cholesterol, and liver triacylglycerol. Thus, HEM may be a potential health-promoting supplement for minimizing the progression of aging and obesity-induced neurodegeneration by reducing metabolic abnormalities and neuroinflammatory cytokines and increasing neurogenesis factors.