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- 저자 : ( Xiaorong Zhu ) (검색결과 5 건)
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Bidirectional Link Resource Allocation Strategy in GFDM-based Multiuser SWIPT Systems
( Xiaorong Xu ),( Minghang Sun ),( Wei-ping Zhu ),( Wei Feng ),( Yingbiao Yao ) 한국인터넷정보학회 2022 KSII Transactions on Internet and Information Syst Vol.16 No.1
In order to enhance system energy efficiency, bidirectional link resource allocation strategy in GFDM-based multiuser SWIPT systems is proposed. In the downlink channel, each SWIPT user applies power splitting (PS) receiver structure in information decoding (ID) and non-linear energy harvesting (EH). In the uplink channel, information transmission power is originated from the harvested energy. An optimization problem is constructed to maximize weighted sum ID achievable rates in the downlink and uplink channels via bidirectional link power allocation as well as subcarriers and subsymbols scheduling. To solve this non-convex optimization problem, Lagrange duality method, sub-gradient-based method and greedy algorithm are adopted respectively. Simulation results show that the proposed strategy is superior to the fixed subcarrier scheme regardless of the weighting coefficients. It is superior to the heuristic algorithm in larger weighting coefficients scenario.
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( Chenjun Zhou ),( Xiaorong Zhu ),( Hongbo Zhu ),( Su Zhao ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.6
The collaborative content caching system is an effective solution developed in recent years to reduce transmission delay and network traffic. In order to decrease the service end-to-end transmission delay for future 5G ultra-dense networks (UDN), this paper proposes a novel service migration method that can guarantee the continuity of service and simultaneously reduce the traffic flow in the network. In this paper, we propose a service migration optimization model that minimizes the cumulative transmission delay within the constraints of quality of service (QoS) guarantee and network condition. Subsequently, we propose an improved firefly algorithm to solve this optimization problem. Simulation results show that compared to traditional collaborative content caching schemes, the proposed algorithm can significantly decrease transmission delay and network traffic flow.
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Prevalence and Prognostic Role of PIK3CA/AKT1 Mutations in Chinese Breast Cancer Patients
Ling Deng,Xuehua Zhu,Yun Sun,Jiemin Wang,Xiaorong Zhong,Jiayuan Li,Min Hu,Hong Zheng 대한암학회 2019 Cancer Research and Treatment Vol.51 No.1
Purpose The prevalence of PIK3CA in Chinese breast cancer patients may be underestimated. Therefore, we investigated the distribution of somatic PIK3CA/AKT1mutations in Chinese breast cancer patients and explored their roles in tumor phenotypes and disease prognosis. Materials and Methods Tumors from 507 breast cancer patients were prospectively collected from the West China Hospital between 2008 and 2013. Whole exons of AKT1 and PIK3CAwere detected in freshfrozen tumors using next-generation sequencing, and correlations between PIK3CA/AKT1 mutations and clinicopathological features were analyzed. Results The AKT1mutation was found in 3.6% (18/507) of patients. Tumors from patients that carried the AKT1mutation were estrogen receptor (ER)+/progesterone receptor (PR)+/human epidermal growth factor receptor 2 (HER2) and were more likely to have high expression levels of Ki67. The prevalence of the PIK3CA mutation was 46.5% (236/507), and 35 patients carried two or three variants of the PIK3CA gene. PIK3CA mutations were associated with ER+/PR+/HER2 status. The prognosis of patients with one mutation in PIK3CA (or PIK3CA/AKT1) was not significantly different than that of patients with wild-type PIK3CA (or PIK3CA/AKT1), while patients with two or three variants in PIK3CA (or PIK3CA/AKT1) exhibited poorer outcomes in the entire group and in all three subgroups (ER+, HER2, Ki67 high), particularly with respect to overall survival. Conclusion A high frequency of somatic PIK3CA mutations was detected in Chinese breast cancer patients. In addition to the mutation frequency, the tumor mutational burden of the PIK3CA and AKT1 genes should also be of concern, as they may be associated with poor prognosis.
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Small-conductance Ca2+-activated K+ channels: insights into their roles in cardiovascular disease
Mingxia Gu,Yanrong Zhu,Xiaorong Yin,Dai-Min Zhang 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Life-threatening malignant arrhythmias in pathophysiological conditions can increase the mortality and morbidity of patients with cardiovascular diseases. Cardiac electrical activity depends on the coordinated propagation of excitatory stimuli and the generation of action potentials in cardiomyocytes. Action potential formation results from the opening and closing of ion channels. Recent studies have indicated that small-conductance calcium-activated potassium (SK) channels play a critical role in cardiac repolarization in pathophysiological but not normal physiological conditions. The aim of this review is to describe the role of SK channels in healthy and diseased hearts, to suggest cardiovascular pathophysiologic targets for intervention, and to discuss studies of agents that target SK channels for the treatment of cardiovascular diseases.
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Limin Cao,Jin Si,Weiyu Wang,Xiaorong Zhao,Xiaomei Yuan,Huifen Zhu,Xiaolong Wu,Jianzhong Zhu,Guanxin Shen 한국분자세포생물학회 2006 Molecules and cells Vol.21 No.1
Gene therapy with nonviral vectors using the suicide gene/prodrug activating system of herpes simplex virus type-1 thymidine kinase (HSV1-TK)/ganciclovir (GCV) is inefficient in killing malignant tumor cells due to two major factors: (a) an unsatisfactory bystander effect; (b) short-lived expression of the protein. To study the capacity of the protein transduction domain (PTD) of HIV-1 TAT protein to enhance HSV1-TK/GCV cancer gene therapy, we constructed three fusion proteins TAT-TK, TK-TAT and TK. TATTK retained as much enzyme activity as TK, whereas that of TK-TAT was much lower. TAT-TK can enter HepG2 cells and much of it is translocated to the nucleus. The transduced HepG2 cells are killed by exogenously added GCV and have bystander effects on untransduced HepG2 cells. Most importantly, the introduced recombinant protein is stable and remains functional for several days at least, probably because nuclear localization protects it from the cytoplasmic degradation machinery and provides access to the nuclear transcription machinery. Our results indicate that TAT fusion proteins traffic intercellularly and have enhanced stability and prodrug cell killing activity. We conclude that TAT has potential for enhancing enzyme prodrug treatment of liver cancers.
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