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The RNA-binding protein repertoire of embryonic stem cells
Kwon, S Chul,Yi, Hyerim,Eichelbaum, Katrin,Fö,hr, Sophia,Fischer, Bernd,You, Kwon Tae,Castello, Alfredo,Krijgsveld, Jeroen,Hentze, Matthias W,Kim, V Narry Nature Publishing Group, a division of Macmillan P 2013 Nature Structural and Molecular Biology Vol.20 No.9
RNA-binding proteins (RBPs) have essential roles in RNA-mediated gene regulation, and yet annotation of RBPs is limited mainly to those with known RNA-binding domains. To systematically identify the RBPs of embryonic stem cells (ESCs), we here employ interactome capture, which combines UV cross-linking of RBP to RNA in living cells, oligo(dT) capture and MS. From mouse ESCs (mESCs), we have defined 555 proteins constituting the mESC mRNA interactome, including 283 proteins not previously annotated as RBPs. Of these, 68 new RBP candidates are highly expressed in ESCs compared to differentiated cells, implicating a role in stem-cell physiology. Two well-known E3 ubiquitin ligases, Trim25 (also called Efp) and Trim71 (also called Lin41), are validated as RBPs, revealing a potential link between RNA biology and protein-modification pathways. Our study confirms and expands the atlas of RBPs, providing a useful resource for the study of the RNA-RBP network in stem cells.
INTENSIVE MONITORING SURVEY OF NEARBY GALAXIES (IMSNG)
Myungshin Im,Changsu Choi,Sungyong Hwang,Gu Lim,Joonho Kim,Sophia Kim,Gregory S. H. Paek,Sang-Yun Lee,Sung-Chul Yoon,Hyunjin Jung,성현일,Yeong-beom Jeon,Shuhrat Ehgamberdiev,Otabek Burhonov,Davron Milzaq 한국천문학회 2019 Journal of The Korean Astronomical Society Vol.52 No.1
Intensive Monitoring Survey of Nearby Galaxies (IMSNG) is a high cadence observation program monitoring nearby galaxies with high probabilities of hosting supernovae (SNe). IMSNG aims to constrain the SN explosion mechanism by inferring sizes of SN progenitor systems through the detection of the shock-heated emission that lasts less than a few days after the SN explosion. To catch the signal, IMSNG utilizes a network of 0.5-m to 1-m class telescopes around the world and monitors the images of 60 nearby galaxies at distances $D < 50$ Mpc to a cadence as short as a few hours. The target galaxies are bright in near-ultraviolet (NUV) with $M_{NUV} < -18.4$ AB mag and have high probabilities of hosting SNe (0.06 SN yr$^{-1}$ per galaxy). With this strategy, we expect to detect the early light curves of 3.4 SNe per year to a depth of $R \sim 19.5$ mag, enabling us to detect the shock-heated emission from a progenitor star with a radius as small as 0.1 $R_{\odot}$. The accumulated data will be also useful for studying aint features around the target galaxies and other science projects. So far, 18 SNe have occurred in our target fields (16 in IMSNG galaxies) over 5 years, confirming our SN rate estimate of 0.06 SN yr$^{-1}$ per galaxy.