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Yaeko Fukushima,Satoshi Kurose,Hiromi Shinno,Ha Cao Thu,Nana Takao,Hiromi Tsutsumi,Yutaka Kimura 대한당뇨병학회 2016 Diabetes and Metabolism Journal Vol.40 No.2
Background: It has recently been suggested that skeletal muscle has an important role in insulin resistance in obesity, in addition to exercise tolerance and the fat index. The aim of this study was to identify body composition factors that contribute to improvement of insulin resistance in female patients with obesity who reduce body weight. Methods: We studied 92 female obese patients (age 40.9±10.4 years, body mass index 33.2±4.6 kg/m²) who reduced body weight by ≥5% after an intervention program including diet, exercise therapy, and cognitive behavioral therapy. Before and after the intervention, body composition was evaluated by dual-energy X-ray absorptiometry to examine changes in skeletal muscle mass. Homeostasis model assessment of insulin resistance (HOMA-IR) was measured as an index of insulin resistance. Cardiopulmonary exercise was also performed by all patients. Results: There were significant improvements in body weight (–10.3%±4.5%), exercise tolerance (anaerobic threshold oxygen uptake 9.1%±18.4%, peak oxygen uptake 11.0%±14.2%), and HOMA-IR (–20.2%±38.3%). Regarding body composition, there were significant decreases in total body fat (–19.3%±9.6%), total fat-free mass (–2.7%±4.3%), and % body fat (–10.1%±7.5%), whereas % skeletal muscle significantly increased (8.9%±7.2%). In stepwise multiple linear regression analysis with change in HOMA-IR as the dependent variable, the change in % skeletal muscle was identified as an independent predictor (β=–0.280, R2=0.068, P<0.01). Conclusion: Improvement of insulin resistance in female obese patients requires maintenance of skeletal muscle mass.
Effects of Body Weight Reduction on Serum Irisin and Metabolic Parameters in Obese Subjects
Yaeko Fukushima,Satoshi Kurose,Hiromi Shinno,Ha Cao Thi Thu,Nana Takao,Hiromi Tsutsumi,Takaaki Hasegawa,Toshiaki Nakajima,Yutaka Kimura 대한당뇨병학회 2016 Diabetes and Metabolism Journal Vol.40 No.5
Background: Irisin is a myokine implicated in lipid and glucose metabolism. The objective of this study is to examine the effect of a body weight reduction on the serum irisin level and physical indicators in obese Japanese patients without diabetes. Methods: The subjects were 22 patients (male/female, 5/17; age, 46.1±16.0 years; body mass index [BMI], 36.9±5.0 kg/m²) who completed a 6-month body weight reduction program at our clinic. The program included diet, exercise therapy and cognitive behavioral therapy. Blood parameters, body composition, exercise tolerance, homeostasis model assessment of insulin resistance (HOMA-IR), and serum irisin were determined before and after intervention, and relationships among changes in these data were examined. Results: There were significant decreases in body weight and BMI after the intervention. Irisin before the intervention was significantly positively correlated with HOMA-IR (r=0.434, P<0.05). The mean irisin level showed no significant change after the intervention in all participants. However, improvements in % body fat, subcutaneous fat area, triglycerides, and fasting glucose were significantly greater in patients with an increase in irisin compared to those with a decrease in irisin after the intervention. Patients with an increase in irisin also had significantly lower fasting insulin (9.7±4.8 vs. 16.4±8.2, P<0.05) and HOMA-IR (2.2±1.1 vs. 3.7±1.6, P<0.05) after the intervention, compared to patients with a decrease in irisin. Conclusion: Body weight reduction did not alter irisin levels. However, irisin may play important roles in fat and glucose metabolism and insulin resistance, and the effects of body weight reduction on irisin kinetics may be a key for obesity treatment.
( Yusuke Kawamura ),( Kenji Ikeda ),( Taito Fukushima ),( Yuya Seko ),( Tasuku Hara ),( Hitomi Sezaki ),( Tetsuya Hosaka ),( Norio Akuta ),( Masahiro Kobayashi ),( Satoshi Saitoh ),( Fumitaka Suzuki ) The Editorial Office of Gut and Liver 2013 Gut and Liver Vol.7 No.5
Background/Aims: The aim of this study was to determine the pharmacodynamics of cisplatin following three different treatment procedures for intrahepatic arterial infusion thera-py for hepatocellular carcinoma (HCC). Methods: We divided 13 HCC patients into the following three groups: group A, lone injection of cisplatin (n=3); group B, combined injection of cisplatin and lipiodol, with embolization using small gela-tin cubes (GCs) (n=5); and group C, injection of suspended lipiodol with cisplatin powder, with embolization using small GCs (n=5). In each group, the free cisplatin concentration in the hepatic vein was measured at 0, 5, 10, and 30 minutes. Results: The mean free cisplatin concentrations were as fol-lows. For group A, the mean was 48.58 μg/mL at 0 minute, 7.31 mL at 5 minutes, 5.70 mL at 10 minutes, and 7.15 mL at 30 minutes. For the same time points, for group B, the concentrations were 8.66, 4.23, 3.22, and 1.65 μg/mL, respectively, and for group C, the concentrations were 4.81, 2.61, 2.52, and 1.75 mL, respectively. The mean area under the curve (AUC)0-infinity for the free cisplatin concentration was 7.80 in group A, 2.48 in group B, and 2.27 in group C. The AUC0-infinity for the free cisplatin concentration gradually decreased, from group A to group C. Conclusions: These results indicate that the combination of lipiodol and small GCs may be useful for delaying cisplatin drainage from the liver. (Gut Liver 2013;7:576-584)
Spin-wave eigenmodes in single disk-shaped FeB nanomagnet
Cho, Jaehun,Miwa, Shinji,Yakushiji, Kay,Tamaru, Shingo,Kubota, Hitoshi,Fukushima, Akio,Fujimoto, Satoshi,Tamura, Eiiti,You, Chun-Yeol,Yuasa, Shinji,Suzuki, Yoshishige American Physical Society 2016 Physical Review B Vol.94 No.18
<P>Spin-wave eigenmodes in a disk-shaped FeB nanomagnet were investigated using magnetic tunnel junctions with a FeB magnetic layer and MgO barrier. Noise spectrum measurements for a perpendicularly magnetized junction of 120 nm in diameter showed thermal excitation of distinct spin-wave modes. The measured spectra were compared with analytical calculations and numerical simulations. As a result, the observed modes were classified as spin-wave eigenmodes with various nodal circles and nodal diameter modes by taking into account splitting between directional spin-wave modes originating from dynamic dipolar interaction instead of Dzyaloshinskii-Moriya interaction. These results provide a fundamental understanding of spin dynamics in nanosize spintronic devices.</P>
시각장애인 침사의 침 시술에 있어서의 위생관리에 대한 일반인의 의식에 관한 연구
전영미(Jun Youngmi),와다 츠네히코(Wada Tsunehiko),쿠리하라 카츠미(Kurihara Katsumi),나카노 야스시(Nakano Yasushi),후쿠시마 사토시(Fukushima Satoshi) 한국직업재활학회 2006 職業再活硏究 Vol.16 No.1
최근 일본에서는 의료 및 침 치료 분야에서 시술상의 수지 위생에 관한 관심이 높아짐에 따라 시각 장애인 침사가 시술을 함에 있어서 위생적 우려가 예측된다. 따라서 본 연구에서는 일본의 시각장애인 침사가 침 시술을 행함에 있어서 위생적 관리가 가능한지에 대한 환자의 입장에 있는 일반인의 우려 정도에 대해 그 실태 파악을 목적으로 대학생 183 명을 대상으로 설문지 조사를 실시하였다. 그 결과 「타인의 도움 없이 위생관리가 가능하다」가 75명(41.0%), 「여러 사물을 손으로 확인하므로 손이 청결한지 걱정된다」가 50명(27.3%), 「진료소 내외의 청소가 잘 이루어져 있지 않다」가 45명 (24.6%), 「침대시트 등의 색깔이 바래있을 것이다」가 15명(8.2%)이 위생적인 면에서 불안을 느끼고 있는 것으로 나타났다. 또한 이러한 시각장애인 침사의 침 시술의 위생관리에 대한 의식 항목과 침 치료의 위생 변에 대한 불안 항목이나 시각장애인의 특정 중 하나인 「물건을 손으로 확인한다」는 항목이 관계를 갖는지에 대해 통계적 분석을 하였다. 그 결과 「타인의 도움 없이 위생관리가 가능 하다」와「침대시트 등의 색깔이 바래있을 것이다」의 항목에서 침 치료의 위생적인 면의 불안과 「물건을 손으로 확인한다」의 항목 모두에서 유의한 관련을 볼 수 있었다. 이에 가세하여 시각 장애인에 대한 의식 항목인 「물건을 손으로 확인한다」와「여러 사물을 손으로 확인하므로 손이 청결한지 걱정 된다」는 항목 간에 의미 있는 관련이 나타났다. 이로 보아 시각장애인이 침사로서의 직무 역사가 긴 일본에서도 시각장애인에 대한 일반인의 부정적 이미지를 소유하고 있음을 확인할 수 있었다. We have surveyed 183 university students using questionnaire method in order to understand general public s feeling toward hygienic control on acupuncture treatment given by the visually impaired acupuncturists. The result showed the followings: 75 students (41%) think visually impaired acupuncturists can not control on hygiene without help , 50 students (27.3%) feel unsure about cleanliness of hands of visually impaired acupuncturists because they touch many things to understand their surroundings. . 45students (24.6%) consider visually impaired acupuncturists can not be kept clean their clinics. . and 15 students think the bed sheets are dull in the clinics of visually impaired acupuncturists . In addition. these images above related to the fear for hygiene of acupuncture treatment and visually impaired person touch things to understand their surroundings that is regarded as the characteristic feature of visually impaired person. The cross analysis shows following two items. the visually impaired acupuncturists can control on hygiene without help and the bed sheets are dull in the clinics of visually impaired acupuncturists have relationship with both fear for hygiene of acupuncture treatment and visually impaired person touch things to understand their surroundings . Furthermore. there is significant relation between visually impaired person touch things to understand their surroundings and I feel unsure about cleanliness of hands of visually impaired acupuncturists because they touch many things to understand their surroundings .