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유착에 의한 AGS 및 Hep-G2 세포 표면 구조의 변화
박동규 ( D. K. Park ),전훈재 ( H. J. Chun ),박재홍 ( J. H. Park ),박철희 ( C. H. Park ),진윤태 ( Y. T. Jeen ),이홍식 ( H. S. Lee ),이상우 ( S. W. Lee ),엄순호 ( S. H. Um ),최재현 ( J. H. Choi ),김창덕 ( C. D. Kim ),류호상 ( H. S. Ryu 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> 최근 H. pylori 유착에 의한 세포 표면 구조의 변화에 관한 연구가 시도되어지고 있으나 actin 의 변화여부 및 그 특성에 관해서는 아직 명확히 정립되지 못한 실정이다. Rho GTPase는 세포 표면의 미세돌기인 microvilli, filopodia 및 membrane ruffle의 형성과 관련이 있으며, 최근 AGS 세포에서 H. pylori가 Rac activation에 의하여 membrane ruffle을 형성한다는 것과 Rac
Um, D.H.,Joo, J.M.,Lee, S.,Kwon, O.C. Pergamon Press ; Elsevier Science Ltd 2013 INTERNATIONAL JOURNAL OF HYDROGEN ENERGY - Vol.38 No.34
The combustion stability (extinction) limits and nitrogen oxide (NO<SUB>x</SUB>) emissions of nonpremixed ammonia (NH<SUB>3</SUB>)-hydrogen (H<SUB>2</SUB>)-air flames at normal temperature and pressure are studied to evaluate the potential of partial NH<SUB>3</SUB> substitution for improving the safety of H<SUB>2</SUB> use and to provide a database for the nonpremixed NH<SUB>3</SUB>-substituted H<SUB>2</SUB>-air flames. Considering coflow nonpremixed NH<SUB>3</SUB>-H<SUB>2</SUB>-air flames for a wide range of fuel and coflow air injection velocities (V<SUB>fuel</SUB> and V<SUB>coflow</SUB>) and the extent of NH<SUB>3</SUB> substitution, the effects of NH<SUB>3</SUB> substitution on the stability limits and NO<SUB>x</SUB> emissions of the NH<SUB>3</SUB>-H<SUB>2</SUB>-air flames are experimentally determined, while the nonpremixed NH<SUB>3</SUB>-H<SUB>2</SUB>-air flame structure is computationally predicted using a detailed reaction mechanism. Results show significant reduction in the stability limits and unremarkable increase in the NO<SUB>x</SUB> emission index for enhanced NH<SUB>3</SUB> substitution, supporting the potential of NH<SUB>3</SUB> as an effective, carbon-free additive in nonpremixed H<SUB>2</SUB>-air flames. With increasing V<SUB>coflow</SUB> the NO<SUB>x</SUB> emission index decreases, while with increasing V<SUB>fuel</SUB> it decreases and then increases due to the recirculation of burned gas and the reduced radiant heat losses, respectively. Given V<SUB>coflow</SUB>/V<SUB>fuel</SUB> the flame length increases with enhanced NH<SUB>3</SUB> substitution since more air is needed for reaction stoichiometry. The predicted flame structure shows that NH<SUB>3</SUB> is consumed more upstream than H<SUB>2</SUB> due to the difference between their diffusivities in air.
Lee, H-S.,Kim, S-K.,Han, J-B.,Choi, H-M.,Park, J-H.,Kim, E-C.,Choi, M-S.,An, H-J.,Um, J-Y.,Kim, H-M.,Min, B-I. 경희대학교 동서의학연구소 2006 東西醫學硏究所 論文集 Vol.2006 No.-
Background Rumex japonicus Houtt. (RJH) is one of the herbs used in Eastern countries for the treatment of atopic dermatitis (AD). It has been shown to have an anti-oxidative effect in human skin disease. Objectives To examine whether RJH extract (RJH-E) suppresses the development of AD-like skin lesions in NC/Nga mice, which are induced by the repeated application of picryl chloride (PC). Methods The efficacy of RJH-E in NC/Nga mice was assessed by measuring symptom severity, scratching behaviour, Staphylococcus aureus numbers on an ear, and serum levels of IgE, interleukin (IL)-4 and interferon (IFN)-γ. Results Oral administration of RJH-E to NC/Nga mice treated with PC inhibited the development of AD-like skin lesions as exemplified by a significant decrease in total skin symptom severity scores, and a decrease in hypertrophy, hyperkeratosis and infiltration of inflammatory cells in the skin. The scratching behaviour and numbers of S. aureus, which are known to be exacerbated in AD, were also significantly reduced by RJH-E. No significant change was observed in the serum levels of IFN-γ, whereas IgE and IL-4 levels were significantly reduced by RJH-E. Conclusions These results suggest that RJH-E inhibits the development of AD-like skin lesions in NC/Nga mice by suppressing the T-helper 2 cell response. Our results indicate that RJH treatment could provide an effective alternative therapy for the management of AD.
Kim, M.,Kim, K.Y.,Lee, K.M.,Youn, S.H.,Lee, S.M.,Woo, H.M.,Oh, M.K.,Um, Y. Elsevier Applied Science 2016 Bioresource technology Vol.218 No.-
The aim of this work was to study the butyric acid production from softwood hydrolysate by acetate-consuming Clostridium sp. S1. Results showed that Clostridium sp. S1 produced butyric acid by simultaneously utilizing glucose and mannose in softwood hydrolysate and, more remarkably, it consumed acetic acid in hydrolysate. Clostridium sp. S1 utilized each of glucose, mannose, and xylose as well as mixed sugars simultaneously with partially repressed xylose utilization. When softwood (Japanese larch) hydrolysate containing glucose and mannose as the main sugars was used, Clostridium sp. S1 produced 21.17g/L butyric acid with the yield of 0.47g/g sugar and the selectivity of 1 (g butyric acid/g total acids) owing to the consumption of acetic acid in hydrolysate. The results demonstrate potential of Clostridium sp. S1 to produce butyric acid selectively and effectively from hydrolysate not only by utilizing mixed sugars simultaneously but also by converting acetic acid to butyric acid.
Fractionation and gasification of black liquor derived from kraft pulping
Kwon, H.S.,Moon, J.H.,Lee, U.D.,Yoon, J.J.,Walsum, G.P.v.,Um, B.H. Korean Society of Industrial and Engineering Chemi 2016 Journal of industrial and engineering chemistry Vol.34 No.-
<P>By combining hydrolysis, it was observed that the maximum concentration of xylose + mannose + galactose (xmg) was 10.7 g/L at a CS of 1.72. The aliphatic acid, aromatic acid and aldehydes were released 29.8, 0.45 and 0.90 from the black liquor at CS of 1.19, 1.72, and 2.19, respectively. In the gasification using bench-scale bubbling fluidized bed (BFB) reactor, high-quality syngas (H-2/CO: 1.47) was obtained from the steam of acid-insoluble lignin (AIL), suitable for conventional energy systems such as gas engines, turbines, and boilers. (C) 2015 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.</P>
Lee, S.I.,Um, D.H.,Kwon, O.C. Pergamon Press ; Elsevier Science Ltd 2013 International journal of hydrogen energy Vol.38 No.22
The potential of ammonia (NH<SUB>3</SUB>)-hydrogen (H<SUB>2</SUB>) blends as a carbon-free, green fuel in a 1-10 W micro-thermophotovoltaic (micro-TPV) device is evaluated experimentally. When NH<SUB>3</SUB>-H<SUB>2</SUB> blends are used directly (without any modification) in a heat-recirculating micro-TPV configuration that has an installation of gallium antimonide (GaSb) photovoltaic cells and was developed for hydrocarbon fuel, low temperature on the micro-emitter outer surface is observed, generating a secondary flame at the micro-emitter outlet. Thus, the micro-TPV device has been modified to eliminate the secondary flame by enhancing the residence time of fed NH<SUB>3</SUB>-H<SUB>2</SUB>-air mixtures and uniform burning: a cyclone adapter for a fuel-air mixture supply system and a helical adapter for the fuel-air mixture upstream of the micro-emitter. Under optimized design and operating conditions, the micro-TPV device produces 5.2 W with an overall efficiency of 2.1% and an emitter efficiency of 37%, indicating the maximum temperature of the micro-emitter outer surface up to 1408 K. Thus, the feasibility of using NH<SUB>3</SUB>-H<SUB>2</SUB> blends in practical micro power-generation devices has been demonstrated, implying the potential of partial NH<SUB>3</SUB> substitution to improve the safety of pure H<SUB>2</SUB> use with no carbon generation.