http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Hao Wen,Changdong Shi,Yuanrui Gao,Hongren Rong,Yanyong Sha,Hongjiang Liu,Qi Liu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.12
Co3O4 nanocrystals have been synthesized via an ordinary one-step calcination of a cobalt-based 2D coordination polymer [Co(tfbdc)(4,4'-bpy)(H2O)2]. As an anode material for lithium-ion batteries, the obtained Co3O4 nanocrystals exhibit high reversible capacity, excellent cyclic stability and better rate capability. The reversible capacity of the Co3O4 nanocrystals maintains 713mA h g-1 after 50 cycles at a current density of 50mA g-1. Our results confirm that searching for metal oxides nanomaterials used as anode materials of lithium ion batteries via the calcinations of 2D coordination polymer is a new route.
ATF3 Activates Stat3 Phosphorylation through Inhibition of p53 Expression in Skin Cancer Cells
Hao, Zhen-Feng,Ao, Jun-Hong,Zhang, Jie,Su, You-Ming,Yang, Rong-Ya Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Aim: ATF3, a member of the ATF/CREB family of transcription factors, has been found to be selectively induced by calcineurin/NFAT inhibition and to enhance keratinocyte tumor formation, although the precise role of ATF3 in human skin cancer and possible mechanisms remain unknown. Methods: In this study, clinical analysis of 30 skin cancer patients and 30 normal donors revealed that ATF3 was accumulated in skin cancer tissues. Functional assays demonstrated that ATF3 significantly promoted skin cancer cell proliferation. Results: Mechanically, ATF3 activated Stat3 phosphorylation in skin cancer cell through regulation of p53 expression. Moreover, the promotion effect of ATF3 on skin cancer cell proliferation was dependent on the p53-Stat3 signaling cascade. Conclusion: Together, the results indicate that ATF3 might promote skin cancer cell proliferation and enhance skin keratinocyte tumor development through inhibiting p53 expression and then activating Stat3 phosphorylation.
Lotus-Like Nano-Architectures Constructed from Self-Assembled Micelles via Hierarchical Assembly
Rongli Zhang,Xiaoxia Fan,Xiaofang Xu,Jingjing Lv,Zhenzhen Jin,Hui Hao,Cuige Zhang 한국고분자학회 2018 Macromolecular Research Vol.26 No.1
Dopamine modified γ-polyglutamic acid (γ-PGA-DA) copolymer and melamine (Mel) can self-assemble into Mel/γ-PGA-DA micelles via weak intermolecular interactions in aqueous solution containing small amount of methanol. When Mel/γ-PGA-DA micellar solution was cast on the surface of formvar stabilized with carbon support films, the lotus-like nano-architectures were formed on the surface of substrate via hierarchical assembly of micelles. The size of lotus-like nanoarchitectures was approximately 200 nm×500 nm. The possible driving forces for hierarchical assembly of micelles were the solution fluid and interaction between micelles. The hierarchical assembly of micelles was similar to the fractal aggregation of inorganic particles and a possible reason was discussed.
Myosin VI contributes to malignant proliferation of human glioma cells
Rong Xu,Xu-hao Fang,Ping Zhong 대한생리학회-대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.2
Previously characterized as a backward motor, myosin VI (<i>MYO6</i>), which belongs to myosin family, moves toward the minus end of the actin track, a direction opposite to all other known myosin members. Recent researches have illuminated the role of <i>MYO6 </i>in human cancers, particularly in prostate cancer. However, the role of <i>MYO6 </i>in glioma has not yet been determined. In this study, to explore the role of <i>MYO6 </i>in human glioma, lentivirus-delivered short hairpin RNA (shRNA) targeting <i>MYO6 </i>was designed to stably down-regulate its endogenous expression in glioblastoma cells U251. Knockdown of <i>MYO6 </i>significantly inhibited viability and proliferation of U251 cells in vitro. Moreover, the cell cycle of U251 cells was arrested at G0/G1 phase with the absence of <i>MYO6</i>, which could contribute to the suppression of cell proliferation. In conclusion, we firstly identified the crucial involvement of <i>MYO6 </i>in human glioma. The inhibition of <i>MYO6 </i>by shRNA might be a potential therapeutic method in human glioma.
Rong Ding,Xin-Sheng Yao,Jinshan Tang,Hao Gao,Ting Li,Hua Zhou,Liang Liu 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.9
Two new methymycin derivatives, 3'-demethylmethymycin (1) and 3'-demethyldeoxymethymycin (2), together with seven known ones (3-9), were obtained from the strain Streptomyces venezuelae ATCC 15439. Their structures were determined on the basis of IR, MS, 1D and 2D NMR data. In addition, the inhibitory effects of all the compounds on human T cell proliferation mediated by PMA/ionomycin were evaluated. The data suggested for the first time that methymycin derivatives have potential anti-inflammatory activity.