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Sebastia Sabater,Meritxell Arenas,Roberto Berenguer,Ignacio Andres,Esther Jimenez-Jimenez,Ana Martos,Jesus Fernandez-Lopez,Mar Sevillano,Angeles Rovirosa 대한암학회 2015 Cancer Research and Treatment Vol.47 No.3
Purpose Association between body mass index (BMI) and doses in organs at risk during postoperative vaginal cuff brachytherapy (VCB) treatment has not been evaluated. The aim of this study was to analyse the impact of BMI on the dose delivered to bladder and rectum during high-dose-rate VCB using computed tomography (CT) scans at every fraction. Materials and Methods A retrospective analysis of 220 planning CT sets derived from 59 patients was conducted. Every planning CT was re-segmented and re-planned under the same parameters. Rectum and bladder dose-volume histogram values (D0.1cc, D1cc, and D2cc) were extracted and evaluated. The mean values for all applications per patient were calculated and correlated with BMI, as well as other factors influencing rectal and bladder doses. Multiple regression analysis performed to model organ at risk dose-volume parameters. Results According to World Health Organization (WHO), 6.8% of patients were normal, 35.6% were overweight, and 57.6% were class I obese. Median rectal doses were 133.5%, 110.9%, and 99.3% for D0.1cc, D1cc, and D2cc, respectively. The corresponding median bladder doses were 96.2%, 80.6%, and 73.3%, respectively. BMI did not show significant association with rectal doses. However, BMI did show a significant association with evaluated bladder dose metrics (D0.1cc, r=–0.366, p=0.004; D1cc, r=–0.454, p < 0.001; D2cc, r=–0.451, p < 0.001). BMI was retained in the multivariate regression models (D0.1cc, p=0.004; D1cc, p < 0.001; D2cc, p=0.001). Conclusion In this group of Mediterranean, overweight, and moderately obese patients, BMI showed association with lower bladder dose values, but not with rectal doses.
Management of Biliopancreatic Limb Bleeding after Roux-en-Y Gastric Bypass: A Case Report
Christophe Riquoir,Luis Antonio Díaz,David Chiliquinga,Roberto Candia,Fernando Pimentel,Alex Arenas 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.5
The Roux-en-Y gastric bypass is one of the most extensive surgical treatments for obesity. The treatment of upper gastrointestinalbleeding after Roux-en-Y gastric bypass is complex due to the difficulty of accessing the excluded gastric antrum and duodenal bulb. There is no consensus regarding the management of this complication. While various techniques have been described to accessthe biliopancreatic limb, double-balloon enteroscopy is the most commonly used. If double-balloon enteroscopy is unavailable, apediatric colonoscope may be used as an alternative; however, its use in such cases has not been described. We report the case of a50-year-old male patient who underwent gastric bypass 13 years ago and was admitted for a second episode of upper gastrointestinalbleeding. The initial approach using upper endoscopy, colonoscopy, and abdominal computed tomography angiography did notreveal the cause of gastrointestinal hemorrhage; therefore, an endoscopic study of the biliopancreatic limb was performed using apediatric colonoscope. A Forrest Ib ulcer was found in the duodenal bulb, and endoscopic therapy was administered. The evolutionwas found to be satisfactory.
( Edoardo Torres-guerrero ),( Elisa Crystal Sanchez-moreno ),( Carlos Enrique Atoche-dieguez ),( Erika Margarita Carrillo-casas ),( Roberto Arenas ),( Juan Xicohtencatl-cortes ),( Rigoberto Hernandez- 대한피부과학회 2018 Annals of Dermatology Vol.30 No.5
Background: The causative agents of leprosy are the well-known Mycobacterium leprae and the newly discovered Mycobacterium lepromatosis. This agent was found in 2008, and it was found to be the cause of diffuse lepromatous leprosy in two Mexican patients. Objective: The objective of this work was to determine if M. leprae and M. lepromatosis were present in formalin-fixed and paraffin- embedded skin samples from cases from different regions in Mexico. Methods: A total of 41 skin samples were obtained from 11 states of Mexico. All patients’ samples were diagnosed by clinical and histopathological analyses. Total DNA was isolated using a Qiagen-DNeasy blood and tissue kit and molecular identification was achieved by two semi-nested polymerase chain reactions. Results: The 41 patient included 33 samples from men and 8 samples from women; 29 samples were polymerase chain reaction (PCR)-positive to Mycobacterium and 12 samples were PCR-negative. From those 29 samples, 13 were PCR-positive to M. leprae, 8 to M. lepromatosis and 8 were positive to both species. The histopathological diagnosis included; Nodular lepromatous leprosy (NLL); Diffuse lepromatous leprosy (DLL); and Borderline leprosy (BL). The 29 PCR-positive samples were classified as follow: 14 NLL, 4 DLL, and 11 BL. In the 12 samples negative to Mycobacterium, 7 showed the NLL, 2 DLL and 3 BL. Conclusion: These findings add evidence to the M. leprae and M. lepromatous distribution, clinical forms and participation of dual infections in Mexico. (Ann Dermatol 30(5) 562∼565, 2018)